SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ono'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 178
ILE A 162
PHE A 125
LEU A 289
GLY A 145
 None
PMK  A 401 ( 3.3A)
PMK  A 401 ( 4.2A)
None
PMK  A 401 (-3.1A)
 1.06A 1e7aB-4onoA:
undetectable		 1e7aB-4onoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 328
ASP A 148
LEU A 150
LEU A 147
 CL  A 406 ( 4.6A)
None
None
None
 0.98A 1e7cA-4onoA:
undetectable		 1e7cA-4onoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 352
THR A 364
SER A 325
VAL A 321
 None
 0.83A 1ictD-4onoA:
undetectable		 1ictD-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 178
VAL A 127
ALA A 215
LEU A 277
PHE A 285
 None
PMK  A 401 (-3.0A)
PMK  A 401 (-2.7A)
PMK  A 401 ( 3.8A)
PMK  A 401 ( 3.6A)
 1.25A 1tbfA-4onoA:
undetectable		 1tbfA-4onoA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 4 LYS A 294
LEU A 290
LEU A 289
SER A 169
 None
 1.49A 1tt6A-4onoA:
undetectable		 1tt6A-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 4 LYS A 294
LEU A 290
LEU A 289
SER A 169
 None
 1.12A 1tz8D-4onoA:
undetectable		 1tz8D-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 7 TYR A  63
GLN A 151
ILE A 130
SER A  52
 None
 1.25A 2xz5A-4onoA:
undetectable
2xz5B-4onoA:
undetectable		 2xz5A-4onoA:
19.42
2xz5B-4onoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 7 GLN A 151
ILE A 130
SER A  52
TYR A  63
 None
 1.23A 2xz5D-4onoA:
undetectable
2xz5E-4onoA:
undetectable		 2xz5D-4onoA:
19.42
2xz5E-4onoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 5 GLN A 230
GLN A 242
ASP A 237
ASP A  59
 None
 1.24A 3bwcB-4onoA:
1.5		 3bwcB-4onoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 145
LEU A  54
SER A  55
ARG A 140
PHE A 185
 PMK  A 401 (-3.1A)
None
None
None
PMK  A 401 (-3.7A)
 1.24A 3bxoB-4onoA:
undetectable		 3bxoB-4onoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 125
THR A 281
GLY A 171
PHE A 173
 PMK  A 401 ( 4.2A)
CL  A 402 (-3.6A)
None
None
 0.95A 3tzfB-4onoA:
undetectable		 3tzfB-4onoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 5 ALA A 200
HIS A  31
PRO A 208
PHE A 233
 None
 1.36A 4ze2A-4onoA:
undetectable		 4ze2A-4onoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  37
PHE A  30
PHE A  62
TRP A 146
VAL A  27
 None
 1.33A 6ap6A-4onoA:
undetectable		 6ap6A-4onoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  37
PHE A  30
PHE A  62
TRP A 146
VAL A  27
 None
 1.35A 6ap6B-4onoA:
undetectable		 6ap6B-4onoA:
20.39