SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ons'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4ons CATENIN ALPHA-2
(Mus
musculus) 		5 / 9 THR A  21
ALA A  92
LEU A  89
GLU A  76
LEU A  72
 None
 1.46A 2azqA-4onsA:
1.7		 2azqA-4onsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ons CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.82A 2e1qA-4onsA:
undetectable		 2e1qA-4onsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ons CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.82A 2e1qC-4onsA:
undetectable		 2e1qC-4onsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ons CATENIN ALPHA-2
(Mus
musculus) 		4 / 7 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.89A 3uniA-4onsA:
2.0		 3uniA-4onsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4ons CATENIN ALPHA-2
CATENIN BETA-1
(Mus
musculus) 		5 / 12 VAL A  35
VAL B 137
GLY A 100
THR A 122
GLY A 121
 None
 1.06A 6brdC-4onsA:
undetectable		 6brdC-4onsA:
15.10