SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4onu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ARG A  46
GLY A  85
VAL A  62
ILE A  57
VAL A  43
 None
 1.05A 1hsgB-4onuA:
undetectable		 1hsgB-4onuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 320
LEU A 256
ALA A 255
PHE A 312
THR A 210
 None
 1.22A 1og5B-4onuA:
undetectable		 1og5B-4onuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 155
ALA A 323
ILE A 317
VAL A 145
ILE A 143
 None
 0.95A 2o4pB-4onuA:
undetectable		 2o4pB-4onuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 218
VAL A 217
GLY A 215
PRO A 142
VAL A 145
 None
 1.12A 3elzC-4onuA:
undetectable		 3elzC-4onuA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 256
PHE A 268
VAL A 263
ALA A 233
 None
 0.93A 3uniB-4onuA:
undetectable		 3uniB-4onuA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TYR A 179
ARG A 181
LYS A 179
 None
 1.13A 4wq5B-4onuA:
undetectable		 4wq5B-4onuA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 182
LEU A 192
PRO A 188
ARG A 181
 None
 1.22A 4yv5A-4onuA:
undetectable		 4yv5A-4onuA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 106
PHE A  18
ALA A  30
LEU A  12
ALA A  13
 None
 1.15A 5oy02-4onuA:
undetectable		 5oy02-4onuA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 249
PHE A 251
THR A 210
ALA A 236
VAL A 235
 None
 1.13A 5x66F-4onuA:
undetectable		 5x66F-4onuA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		5 / 10 TRP A 108
ILE A 106
ALA A  30
LEU A  12
ALA A  13
 None
 1.47A 5zjiB-4onuA:
undetectable		 5zjiB-4onuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4onu ACETYLTRANSFERASE
PAT
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A 139
ARG A 135
ALA A  97
 None
 0.94A 6ecfB-4onuA:
undetectable		 6ecfB-4onuA:
24.59