SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 10 GLU A 184
ARG A 162
ALA A 153
PHE A 185
GLY A 122
 None
None
PO4  A 304 ( 4.0A)
None
PO4  A 304 (-3.5A)
 1.30A 1cmcA-4oo0A:
undetectable
1cmcB-4oo0A:
undetectable		 1cmcA-4oo0A:
26.25
1cmcB-4oo0A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		4 / 6 LEU A 207
THR A  69
ALA A 132
LEU A 141
 None
 1.19A 1etb2-4oo0A:
undetectable		 1etb2-4oo0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		4 / 6 HIS A 125
LEU A 120
PHE A 152
VAL A 150
 None
 1.31A 1ibgH-4oo0A:
undetectable		 1ibgH-4oo0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		4 / 4 LEU A 128
THR A  95
ILE A  99
HIS A 125
 None
 1.07A 2jfaB-4oo0A:
undetectable		 2jfaB-4oo0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		3 / 3 MET A 197
VAL A  65
GLU A 203
 None
 0.89A 2x9gA-4oo0A:
undetectable		 2x9gA-4oo0A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		4 / 4 VAL A 131
ARG A 147
ILE A 196
THR A  69
 None
PO4  A 303 (-4.0A)
EDO  A 306 (-4.9A)
None
 1.33A 3cl9A-4oo0A:
undetectable		 3cl9A-4oo0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 10 VAL A 131
PHE A  38
LEU A  18
VAL A 133
THR A 129
 None
 1.25A 4eilB-4oo0A:
undetectable		 4eilB-4oo0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 10 ILE A 189
VAL A 150
ALA A 182
ALA A 183
ILE A 186
 None
 0.98A 4lbgA-4oo0A:
undetectable		 4lbgA-4oo0A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 9 ILE A 189
VAL A 150
ALA A 182
ALA A 183
ILE A 186
 None
 1.04A 4lbgB-4oo0A:
undetectable		 4lbgB-4oo0A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 11 LEU A 199
GLU A  29
LEU A  31
LEU A  20
LEU A  91
 None
 0.95A 4wg0C-4oo0A:
undetectable
4wg0D-4oo0A:
undetectable
4wg0E-4oo0A:
undetectable		 4wg0C-4oo0A:
3.86
4wg0D-4oo0A:
3.86
4wg0E-4oo0A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 11 LEU A 199
GLU A  29
LEU A  31
LEU A  20
LEU A  91
 None
 0.97A 4wg0E-4oo0A:
undetectable
4wg0F-4oo0A:
undetectable
4wg0G-4oo0A:
undetectable		 4wg0E-4oo0A:
3.86
4wg0F-4oo0A:
3.86
4wg0G-4oo0A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 11 LEU A 199
GLU A  29
LEU A  31
LEU A  20
LEU A  91
 None
 0.96A 4wg0G-4oo0A:
undetectable
4wg0H-4oo0A:
undetectable
4wg0I-4oo0A:
undetectable		 4wg0G-4oo0A:
3.86
4wg0H-4oo0A:
3.86
4wg0I-4oo0A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		3 / 3 ASP A 112
LEU A 104
GLY A 105
 None
 0.52A 4xmfA-4oo0A:
undetectable		 4xmfA-4oo0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4oo0 MAF-LIKE PROTEIN
BCAL2394
(Burkholderia
cenocepacia) 		5 / 11 GLY A 180
MET A 116
LEU A 117
LEU A 120
ILE A 186
 None
 0.97A 4xumB-4oo0A:
undetectable		 4xumB-4oo0A:
19.86