SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oo2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 11 GLU A 266
HIS A 458
LEU A 323
LEU A 260
PRO A 259
 None
 1.46A 1mjqA-4oo2A:
undetectable
1mjqB-4oo2A:
undetectable		 1mjqA-4oo2A:
12.24
1mjqB-4oo2A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 PHE A 307
ALA A 305
LEU A 373
PRO A 374
LEU A  99
 None
 1.15A 1og5A-4oo2A:
undetectable		 1og5A-4oo2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 ALA A 402
LEU A 405
MET A 443
ALA A 327
ALA A 333
 None
 1.17A 1sa1A-4oo2A:
undetectable
1sa1B-4oo2A:
undetectable		 1sa1A-4oo2A:
21.60
1sa1B-4oo2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 ALA A 402
LEU A 405
MET A 443
ALA A 327
ALA A 333
 None
 1.17A 1sa1C-4oo2A:
undetectable
1sa1D-4oo2A:
undetectable		 1sa1C-4oo2A:
21.60
1sa1D-4oo2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 ILE A 106
ALA A 107
ARG A 111
ARG A 350
PHE A  89
 None
 1.31A 1y0xX-4oo2A:
undetectable		 1y0xX-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		4 / 8 ASP A 122
SER A 120
TYR A 123
TYR A 465
 None
 1.29A 2bteD-4oo2A:
undetectable		 2bteD-4oo2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 9 GLY A 451
LEU A 394
ALA A 449
LEU A 324
LEU A 260
 None
 1.03A 2npnA-4oo2A:
undetectable		 2npnA-4oo2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		4 / 5 ALA A 209
ALA A 201
ALA A 269
VAL A  36
 None
 0.94A 2nyrB-4oo2A:
undetectable		 2nyrB-4oo2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		4 / 8 ASP A 122
SER A 120
TYR A 123
TYR A 465
 None
 1.23A 2v0gA-4oo2A:
undetectable		 2v0gA-4oo2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 9 ALA A 105
SER A 120
GLY A 118
SER A 108
ALA A 110
 None
 1.30A 2vh3A-4oo2A:
1.3		 2vh3A-4oo2A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 LYS A 124
ILE A 182
PHE A 181
 None
 0.97A 3j7zS-4oo2A:
undetectable
3j7za-4oo2A:
undetectable		 3j7zS-4oo2A:
11.60
3j7za-4oo2A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		4 / 7 TYR A 465
GLU A 462
TYR A 382
PHE A 353
 None
 1.20A 3ku9B-4oo2A:
undetectable		 3ku9B-4oo2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		4 / 6 VAL A 156
GLY A  23
GLU A  25
TYR A  26
 None
 0.87A 4dxuA-4oo2A:
undetectable		 4dxuA-4oo2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 11 GLY A 118
TYR A 461
SER A 120
TYR A 382
HIS A 308
 None
 1.42A 4ey7A-4oo2A:
undetectable		 4ey7A-4oo2A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 11 GLY A 118
TYR A 461
SER A 120
TYR A 382
HIS A 308
 None
 1.40A 4ey7B-4oo2A:
undetectable		 4ey7B-4oo2A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.92A 4k8cA-4oo2A:
undetectable		 4k8cA-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.91A 4kahA-4oo2A:
undetectable		 4kahA-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.91A 4kahB-4oo2A:
undetectable		 4kahB-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.92A 4kanA-4oo2A:
undetectable		 4kanA-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.91A 4kanB-4oo2A:
undetectable		 4kanB-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.92A 4kbeA-4oo2A:
undetectable		 4kbeA-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.90A 4kbeB-4oo2A:
undetectable		 4kbeB-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.92A 4lbgA-4oo2A:
undetectable		 4lbgA-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		3 / 3 SER A 126
TYR A 123
PRO A 374
 None
 0.91A 4lbgB-4oo2A:
undetectable		 4lbgB-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 9 ALA A 201
THR A 202
ALA A 269
ILE A 212
ALA A 210
 None
 1.13A 4qvqK-4oo2A:
undetectable
4qvqL-4oo2A:
undetectable		 4qvqK-4oo2A:
18.49
4qvqL-4oo2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 9 ALA A 201
THR A 202
ALA A 269
ILE A 212
ALA A 210
 None
 1.13A 4qvqY-4oo2A:
undetectable
4qvqZ-4oo2A:
undetectable		 4qvqY-4oo2A:
18.49
4qvqZ-4oo2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 ILE A 106
ALA A 107
ARG A 111
ARG A 350
PHE A  89
 None
 1.30A 4zo1X-4oo2A:
undetectable		 4zo1X-4oo2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 GLY A  82
GLY A 132
ALA A 133
GLN A 153
THR A 371
 None
 0.90A 5w4zA-4oo2A:
undetectable		 5w4zA-4oo2A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4oo2 CHLOROPHENOL-4-MONOO
XYGENASE
(Streptomyces
globisporus) 		5 / 12 GLY A  82
GLY A 132
ALA A 133
GLN A 153
THR A 371
 None
 0.91A 5w4zB-4oo2A:
undetectable		 5w4zB-4oo2A:
8.99