SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 ASP A 142
ASP A 171
LYS A 125
 None
 1.01A 1lqtB-4oo3A:
4.0		 1lqtB-4oo3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 ASP A 142
ASP A 171
LYS A 125
 None
 1.03A 1lquB-4oo3A:
2.8		 1lquB-4oo3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 10 LEU A 187
ALA A 392
VAL A 368
MET A 387
LEU A 383
 None
 1.30A 1rlbE-4oo3A:
undetectable		 1rlbE-4oo3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 11 GLU A 443
TRP A 442
GLN A 252
ARG A 176
ASP A 249
 None
 1.36A 2no6B-4oo3A:
undetectable		 2no6B-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 11 GLU A 443
TRP A 442
GLN A 252
ARG A 176
ASP A 249
 None
 1.35A 2noaB-4oo3A:
1.8		 2noaB-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 GLU A 443
GLN A 252
ARG A 176
ASP A 249
 None
 1.01A 3mjrD-4oo3A:
2.2		 3mjrD-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 GLN A 184
PRO A 364
GLN A 356
GLU A 365
 None
 1.04A 3oyaA-4oo3A:
undetectable		 3oyaA-4oo3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 5 GLN A 118
THR A 174
HIS A 419
LEU A  50
 None
 1.15A 4lvcA-4oo3A:
4.8		 4lvcA-4oo3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 5 GLN A 118
THR A 174
HIS A 419
LEU A  50
 None
 1.14A 4lvcC-4oo3A:
undetectable		 4lvcC-4oo3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 12 GLY A 237
ASN A 122
ASP A 232
ILE A 240
ASN A 234
 None
 1.33A 4pooB-4oo3A:
5.1		 4pooB-4oo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 5 LEU A 448
ALA A 146
THR A 126
ILE A 129
 None
 0.89A 4xe3A-4oo3A:
undetectable		 4xe3A-4oo3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 7 LYS A  37
TYR A  64
TYR A  66
LEU A  41
 None
 1.09A 4yv5B-4oo3A:
undetectable		 4yv5B-4oo3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 6 VAL A 368
ALA A 350
VAL A 193
TYR A 194
 None
 0.86A 5i8fA-4oo3A:
undetectable		 5i8fA-4oo3A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 ARG A 226
GLY A 237
ASP A 242
TRP A 329
 None
 0.85A 5kf8A-4oo3A:
undetectable		 5kf8A-4oo3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 ARG A 226
GLY A 237
ASP A 242
TRP A 329
 None
 0.87A 5kgpA-4oo3A:
undetectable		 5kgpA-4oo3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 ARG A 226
GLY A 237
ASP A 242
TRP A 329
 None
 0.90A 5kgpB-4oo3A:
undetectable		 5kgpB-4oo3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 LEU A 247
LEU A 250
TRP A 253
 None
 0.85A 5nwuA-4oo3A:
undetectable		 5nwuA-4oo3A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4oo3 HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 5 GLN A 118
THR A 174
HIS A 419
LEU A  50
 None
 1.19A 6gbnA-4oo3A:
3.9		 6gbnA-4oo3A:
21.29