SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oog RIBONUCLEASE 3
RIBONUCLEASE 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A  47
CYH C 404
ASP C 434
ALA C 431
ALA C 428
 None
 1.14A 2br4A-4oogA:
undetectable		 2br4A-4oogA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		5 / 12 GLY C 407
LEU C 383
ARG C 384
ALA C 381
ASP C 457
 None
None
None
C  D  19 ( 3.4A)
None
 1.07A 3gwwA-4oogC:
undetectable		 3gwwA-4oogC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 405
ILE C 420
THR C 394
 None
U  D   5 ( 3.6A)
None
 0.67A 3ia4D-4oogC:
undetectable		 3ia4D-4oogC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		5 / 12 PRO C 336
GLY C 324
ARG C 213
VAL C 214
ILE C 205
 None
 1.28A 3jb2A-4oogC:
undetectable		 3jb2A-4oogC:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		4 / 7 TYR C 322
ASN C 334
LEU C 326
ASP C 329
 None
 1.23A 3lslA-4oogC:
undetectable
3lslD-4oogC:
undetectable		 3lslA-4oogC:
21.05
3lslD-4oogC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		4 / 6 TYR C 322
ASN C 334
LEU C 326
ASP C 329
 None
 1.19A 3lslG-4oogC:
undetectable		 3lslG-4oogC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		5 / 9 LEU C 294
LEU C 314
ILE C 281
ILE C 323
GLU C 320
 None
None
None
None
MG  C 601 ( 2.5A)
 1.33A 3tmzA-4oogC:
undetectable		 3tmzA-4oogC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 288
TRP C 341
LEU C 248
MET C 252
 None
 0.98A 3uzzB-4oogC:
undetectable		 3uzzB-4oogC:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		5 / 6 ALA A 103
ASN A  72
LEU A  73
VAL A  74
ASP A 110
 None
 1.36A 4g24A-4oogA:
undetectable		 4g24A-4oogA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		4 / 8 ILE C 422
ARG C 426
TYR C 387
ASP C 364
 None
None
U  D  21 ( 4.8A)
None
 1.07A 5vlmF-4oogC:
undetectable		 5vlmF-4oogC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		4 / 7 ALA C 428
GLY C 424
GLY C 415
ASN C 369
 None
None
None
G  D  14 ( 4.4A)
 0.79A 5ybbB-4oogC:
undetectable		 5ybbB-4oogC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 319
ILE C 323
TYR C 288
LEU C 248
LEU C 275
 None
 1.36A 5zwrB-4oogC:
undetectable		 5zwrB-4oogC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4oog RIBONUCLEASE 3
(Saccharomyces
cerevisiae) 		3 / 3 GLU C 265
LEU C 268
ARG C 272
 U  D   3 ( 4.7A)
None
C  D   1 ( 3.5A)
 0.81A 6d8fA-4oogC:
undetectable		 6d8fA-4oogC:
17.01