SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ook'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.95A 1c9sP-4ookA:
undetectable
1c9sQ-4ookA:
undetectable		 1c9sP-4ookA:
13.69
1c9sQ-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.95A 1gtfJ-4ookA:
undetectable
1gtfK-4ookA:
undetectable		 1gtfJ-4ookA:
13.69
1gtfK-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.94A 1gtfQ-4ookA:
undetectable
1gtfR-4ookA:
undetectable		 1gtfQ-4ookA:
13.69
1gtfR-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.92A 1gtfS-4ookA:
undetectable
1gtfT-4ookA:
undetectable		 1gtfS-4ookA:
13.69
1gtfT-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 141
HIS A 140
THR A 236
THR A 271
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.97A 1gtnF-4ookA:
undetectable
1gtnG-4ookA:
undetectable		 1gtnF-4ookA:
13.69
1gtnG-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 141
HIS A 140
THR A 236
THR A 271
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.99A 1gtnJ-4ookA:
undetectable
1gtnK-4ookA:
undetectable		 1gtnJ-4ookA:
13.69
1gtnK-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.94A 1gtnT-4ookA:
undetectable
1gtnU-4ookA:
undetectable		 1gtnT-4ookA:
13.69
1gtnU-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 1gtnL-4ookA:
undetectable
1gtnV-4ookA:
undetectable		 1gtnL-4ookA:
13.69
1gtnV-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  12
SER A  13
ASP A  75
PHE A 100
 None
 1.01A 1ismB-4ookA:
undetectable		 1ismB-4ookA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  97
HIS A 212
HIS A 205
ASN A 144
ASP A 131
 None
None
CO  A 302 (-3.2A)
None
CO  A 301 (-1.9A)
 1.34A 1ituA-4ookA:
undetectable		 1ituA-4ookA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  52
ALA A  53
HIS A 140
 None
NA  A 305 ( 4.5A)
None
 0.71A 1q23H-4ookA:
undetectable		 1q23H-4ookA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  52
ALA A  53
HIS A 140
 None
NA  A 305 ( 4.5A)
None
 0.79A 1q23L-4ookA:
undetectable		 1q23L-4ookA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  52
ALA A  53
HIS A 140
 None
NA  A 305 ( 4.5A)
None
 0.70A 1q23J-4ookA:
undetectable		 1q23J-4ookA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.96A 1utdE-4ookA:
undetectable
1utdF-4ookA:
undetectable		 1utdE-4ookA:
13.69
1utdF-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.95A 1utdH-4ookA:
undetectable
1utdI-4ookA:
undetectable		 1utdH-4ookA:
13.69
1utdI-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.90A 1utdL-4ookA:
undetectable
1utdM-4ookA:
undetectable		 1utdL-4ookA:
13.69
1utdM-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.93A 1utdO-4ookA:
undetectable
1utdP-4ookA:
undetectable		 1utdO-4ookA:
13.69
1utdP-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.93A 1utdS-4ookA:
undetectable
1utdT-4ookA:
undetectable		 1utdS-4ookA:
13.69
1utdT-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.93A 1utdL-4ookA:
undetectable
1utdV-4ookA:
undetectable		 1utdL-4ookA:
13.69
1utdV-4ookA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 CYH A 105
HIS A 114
HIS A 212
TRP A 255
 None
CO  A 303 (-3.4A)
None
None
 0.73A 1yvmA-4ookA:
38.0		 1yvmA-4ookA:
44.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  97
CYH A 105
HIS A 114
HIS A 212
 None
None
CO  A 303 (-3.4A)
None
 0.53A 1yvmA-4ookA:
38.0		 1yvmA-4ookA:
44.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 144
ASN A 129
ILE A 127
THR A 167
 None
 1.22A 2hkkA-4ookA:
undetectable		 2hkkA-4ookA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 129
VAL A 128
PHE A 147
ALA A  67
ASP A 142
 None
None
None
None
CO  A 301 ( 2.5A)
 1.35A 2iyfA-4ookA:
undetectable		 2iyfA-4ookA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 140
ALA A  90
ALA A  53
ALA A 134
TYR A 135
 None
None
NA  A 305 ( 4.5A)
None
None
 1.28A 2r2vC-4ookA:
undetectable
2r2vF-4ookA:
undetectable
2r2vG-4ookA:
undetectable		 2r2vC-4ookA:
12.96
2r2vF-4ookA:
12.96
2r2vG-4ookA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 140
ALA A  90
ALA A 134
SER A  93
TYR A 135
 None
 1.38A 2r2vC-4ookA:
undetectable
2r2vF-4ookA:
undetectable
2r2vG-4ookA:
undetectable		 2r2vC-4ookA:
12.96
2r2vF-4ookA:
12.96
2r2vG-4ookA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 SER A  93
HIS A 205
HIS A 140
PHE A 211
THR A 271
 None
CO  A 302 (-3.2A)
None
None
NA  A 305 ( 3.9A)
 1.44A 2vfuA-4ookA:
0.0		 2vfuA-4ookA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  59
ALA A  60
ILE A 136
THR A  94
VAL A 132
 None
 0.94A 3el4A-4ookA:
undetectable		 3el4A-4ookA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 112
LEU A   7
THR A 146
ILE A 127
THR A 256
 NA  A 304 (-4.8A)
None
None
None
None
 1.12A 4ej1B-4ookA:
undetectable		 4ej1B-4ookA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 211
TYR A  91
TYR A  27
 None
 1.11A 4ffwA-4ookA:
undetectable		 4ffwA-4ookA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 112
LEU A   7
THR A 146
ILE A 127
THR A 256
 NA  A 304 (-4.8A)
None
None
None
None
 1.14A 4qleA-4ookA:
undetectable		 4qleA-4ookA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  90
GLY A  59
ALA A  60
GLU A  63
 None
 0.76A 4r1zB-4ookA:
undetectable		 4r1zB-4ookA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 112
LEU A   7
THR A 146
ILE A 127
THR A 256
 NA  A 304 (-4.8A)
None
None
None
None
 1.12A 4x5hA-4ookA:
undetectable		 4x5hA-4ookA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 112
LEU A   7
THR A 146
ILE A 127
THR A 256
 NA  A 304 (-4.8A)
None
None
None
None
 1.12A 4x5jA-4ookA:
undetectable		 4x5jA-4ookA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 165
ILE A 187
LEU A 246
ILE A 241
 None
 0.98A 4xumA-4ookA:
undetectable		 4xumA-4ookA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 142
ALA A  53
THR A 271
THR A 283
 CO  A 301 ( 2.5A)
NA  A 305 ( 4.5A)
NA  A 305 ( 3.9A)
None
 1.49A 4z4gA-4ookA:
undetectable		 4z4gA-4ookA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5eevA-4ookA:
undetectable
5eevB-4ookA:
undetectable		 5eevA-4ookA:
13.69
5eevB-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5eewA-4ookA:
undetectable
5eewB-4ookA:
undetectable		 5eewA-4ookA:
13.69
5eewB-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5eexA-4ookA:
undetectable
5eexB-4ookA:
undetectable		 5eexA-4ookA:
13.69
5eexB-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5eeyA-4ookA:
undetectable
5eeyB-4ookA:
undetectable		 5eeyA-4ookA:
13.69
5eeyB-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5eezA-4ookA:
undetectable
5eezB-4ookA:
undetectable		 5eezA-4ookA:
13.69
5eezB-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5ef0A-4ookA:
undetectable
5ef0B-4ookA:
undetectable		 5ef0A-4ookA:
13.69
5ef0B-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5ef1A-4ookA:
undetectable
5ef1B-4ookA:
undetectable		 5ef1A-4ookA:
13.69
5ef1B-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5ef2A-4ookA:
undetectable
5ef2B-4ookA:
undetectable		 5ef2A-4ookA:
13.69
5ef2B-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 5ef3A-4ookA:
undetectable
5ef3B-4ookA:
undetectable		 5ef3A-4ookA:
13.69
5ef3B-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 TYR A 190
THR A 163
PRO A 239
ALA A 170
ILE A 187
 None
 1.11A 5ewjA-4ookA:
undetectable
5ewjB-4ookA:
undetectable		 5ewjA-4ookA:
19.80
5ewjB-4ookA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 190
THR A 163
PRO A 239
ALA A 170
ILE A 187
 None
 1.10A 5ewjC-4ookA:
undetectable
5ewjD-4ookA:
undetectable		 5ewjC-4ookA:
19.80
5ewjD-4ookA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 6 GLU A  35
PHE A 100
THR A  94
TYR A  97
 None
 0.97A 5lrbA-4ookA:
undetectable		 5lrbA-4ookA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 208
THR A  43
LEU A 180
LEU A 215
 None
 1.06A 5nfjB-4ookA:
undetectable		 5nfjB-4ookA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 208
THR A  43
LEU A 180
LEU A 215
 None
 1.08A 5nfjC-4ookA:
undetectable		 5nfjC-4ookA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 204
HIS A 205
ASP A 142
HIS A 114
 None
CO  A 302 (-3.2A)
CO  A 301 ( 2.5A)
CO  A 303 (-3.4A)
 0.69A 5nnwD-4ookA:
undetectable		 5nnwD-4ookA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 204
HIS A 205
ASP A 142
HIS A 114
 None
CO  A 302 (-3.2A)
CO  A 301 ( 2.5A)
CO  A 303 (-3.4A)
 0.70A 5no9D-4ookA:
undetectable		 5no9D-4ookA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ook METHIONINE
AMINOPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 112
LEU A   7
THR A 146
ILE A 127
THR A 256
 NA  A 304 (-4.8A)
None
None
None
None
 1.15A 5z6fA-4ookA:
undetectable		 5z6fA-4ookA:
22.11