SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 4 SER B 242
LEU B 179
TYR B 258
GLY B 184
 None
 1.43A 1liiA-4oouB:
1.7		 1liiA-4oouB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 12 LEU B 339
LEU B 309
PHE B 276
VAL B 130
ALA B 174
 None
 1.21A 1n5xA-4oouB:
undetectable		 1n5xA-4oouB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 12 LEU B 339
LEU B 309
PHE B 276
VAL B 130
ALA B 174
 None
 1.21A 1n5xB-4oouB:
undetectable		 1n5xB-4oouB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 4 LEU B 263
THR B 264
ILE B 229
HIS B 230
 None
 0.91A 2jfaB-4oouB:
undetectable		 2jfaB-4oouB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 12 ILE B 225
SER B 226
ILE B 229
LEU B 131
VAL B 164
 None
 0.96A 2nnhA-4oouB:
undetectable		 2nnhA-4oouB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		3 / 3 ARG B 298
ASN B 289
THR B 249
 None
 0.82A 2q63A-4oouB:
undetectable		 2q63A-4oouB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 7 HIS B 257
ARG B 255
TYR B 196
LYS B 259
 None
 1.36A 2q6uA-4oouB:
0.0		 2q6uA-4oouB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		6 / 12 ASN B 180
GLU B 181
HIS B 280
TYR B 282
GLU B 312
TRP B 341
 TRS  B 401 (-2.8A)
TRS  B 401 (-3.0A)
None
None
TRS  B 401 (-2.9A)
TRS  B 401 (-4.1A)
 0.80A 2v3dA-4oouB:
5.8		 2v3dA-4oouB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 11 ASN B 180
GLU B 181
TYR B 282
GLU B 312
TRP B 341
 TRS  B 401 (-2.8A)
TRS  B 401 (-3.0A)
None
TRS  B 401 (-2.9A)
TRS  B 401 (-4.1A)
 0.89A 2v3dB-4oouB:
5.2		 2v3dB-4oouB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 7 ASP B 233
LEU B 237
TYR B  32
ILE B 381
 None
 0.99A 3avpA-4oouB:
undetectable		 3avpA-4oouB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 11 LEU B 219
GLY B 265
LYS B 269
ILE B 222
SER B 227
 None
 1.22A 3gyqB-4oouB:
undetectable		 3gyqB-4oouB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 6 GLY B  54
VAL B  84
HIS B  85
SER B  91
 None
 1.00A 3tj7C-4oouB:
undetectable
3tj7D-4oouB:
undetectable		 3tj7C-4oouB:
19.79
3tj7D-4oouB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 6 VAL B  84
HIS B  85
SER B  91
GLY B  54
 None
 1.04A 3tj7C-4oouB:
undetectable
3tj7D-4oouB:
undetectable		 3tj7C-4oouB:
19.79
3tj7D-4oouB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 7 ALA B 362
SER B 318
GLY B 322
GLU B 321
 None
 0.82A 4r1zB-4oouB:
undetectable		 4r1zB-4oouB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 12 ALA B 266
ILE B 222
ILE B 156
ASN B 153
LEU B 152
 None
 1.09A 4r3aA-4oouB:
undetectable		 4r3aA-4oouB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		5 / 12 ALA B 266
ILE B 222
ILE B 156
ASN B 153
LEU B 152
 None
 1.02A 4r3aB-4oouB:
undetectable		 4r3aB-4oouB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 7 GLU B 177
LEU B 129
LEU B 173
LEU B 117
 None
 0.75A 4wg0B-4oouB:
undetectable
4wg0C-4oouB:
undetectable		 4wg0B-4oouB:
3.83
4wg0C-4oouB:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 7 LEU B 173
LEU B 117
GLU B 177
LEU B 129
 None
 0.82A 4wg0L-4oouB:
undetectable
4wg0M-4oouB:
undetectable		 4wg0L-4oouB:
3.83
4wg0M-4oouB:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		4 / 6 SER B  75
GLY B  41
MET B 360
ILE B  69
 None
 1.11A 5j4nA-4oouB:
undetectable		 5j4nA-4oouB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4oou BETA-1,4-MANNANASE
(Cryptopygus
antarcticus) 		6 / 12 LEU B 186
GLY B 184
GLU B  87
GLY B 134
GLY B 209
GLY B 207
 None
 1.38A 5zhmB-4oouB:
undetectable		 5zhmB-4oouB:
19.23