SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4opa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		4 / 5 GLN B  10
ALA B  60
GLN B  63
ILE B  64
 None
 0.57A 2z0aA-4opaB:
12.8		 2z0aA-4opaB:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		4 / 4 ASP B  12
ASP B  39
SER B  42
ARG B  46
 None
 0.35A 2z0aC-4opaB:
12.7		 2z0aC-4opaB:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		3 / 3 ARG B  19
ILE B  54
THR B  49
 None
 0.69A 3ia4D-4opaB:
undetectable		 3ia4D-4opaB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		4 / 5 LEU B  85
ASP B 134
GLU B 137
VAL B 169
 None
 1.27A 4nkvA-4opaB:
undetectable		 4nkvA-4opaB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 10 ALA B 107
VAL B 169
LEU B 193
LEU B 139
LEU B 142
 None
 1.33A 4zmeB-4opaB:
undetectable		 4zmeB-4opaB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 12 MET B  99
ALA B 144
LEU B 142
LEU B 141
LEU B 180
 None
 1.06A 4zn7A-4opaB:
undetectable		 4zn7A-4opaB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4opa NONSTRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		4 / 5 ASP B  87
GLU B  91
ARG B 143
THR B  89
 None
 1.30A 5uxcA-4opaB:
undetectable		 5uxcA-4opaB:
21.79