SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4opf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 7 THR A6374
THR A6515
GLY A6513
ASP A6512
 None
 0.88A 1bu5A-4opfA:
undetectable		 1bu5A-4opfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 8 THR A6374
THR A6515
GLY A6513
ASP A6512
 None
 0.90A 1bu5B-4opfA:
undetectable		 1bu5B-4opfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 10 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 1.03A 1d4yA-4opfA:
undetectable		 1d4yA-4opfA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 11 LEU A6197
VAL A6343
GLY A6300
LEU A6303
GLU A6201
 None
 1.31A 1jkhA-4opfA:
undetectable
1jkhB-4opfA:
undetectable		 1jkhA-4opfA:
20.96
1jkhB-4opfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		3 / 3 PRO A6380
ASP A6371
ASP A6512
 None
 0.71A 1sqfA-4opfA:
undetectable		 1sqfA-4opfA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 ILE A6123
ALA A6124
ALA A6352
HIS A6282
LEU A6281
 None
 1.03A 1xiuB-4opfA:
undetectable		 1xiuB-4opfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 GLY A6226
ALA A6277
VAL A6457
VAL A6297
ILE A6454
 None
 0.88A 2avsB-4opfA:
undetectable		 2avsB-4opfA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		3 / 3 ARG A6149
GLY A6134
PRO A6133
 None
 0.73A 2hreD-4opfA:
undetectable		 2hreD-4opfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 11 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 0.99A 2o4pA-4opfA:
undetectable		 2o4pA-4opfA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 10 VAL A6270
SER A6275
SER A6509
ASN A6516
VAL A6368
 None
 1.47A 2x2iD-4opfA:
undetectable		 2x2iD-4opfA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 6 LEU A6345
VAL A6126
LEU A6288
ASP A6122
 None
 0.90A 3cs9D-4opfA:
undetectable		 3cs9D-4opfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 10 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 0.96A 3lzvA-4opfA:
undetectable		 3lzvA-4opfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 7 VAL A6126
VAL A6298
ILE A6123
ARG A6219
 None
 1.18A 3ms9B-4opfA:
undetectable		 3ms9B-4opfA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 9 GLY A6226
ALA A6277
VAL A6457
VAL A6297
ILE A6454
 None
 0.76A 3oxvC-4opfA:
undetectable		 3oxvC-4opfA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 GLY A6226
ALA A6277
VAL A6457
VAL A6297
ILE A6454
 None
 0.80A 3oxxA-4opfA:
undetectable		 3oxxA-4opfA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 10 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 0.98A 3oy4B-4opfA:
undetectable		 3oy4B-4opfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6198
GLY A6340
ALA A6451
ALA A6277
LEU A6303
 None
 1.07A 3p5nA-4opfA:
undetectable		 3p5nA-4opfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6198
GLY A6340
ALA A6451
ALA A6277
LEU A6303
 None
 1.07A 3p5nB-4opfA:
undetectable		 3p5nB-4opfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 8 ALA A6295
LEU A6288
ALA A6352
ALA A6351
 None
 0.72A 3r9tA-4opfA:
undetectable		 3r9tA-4opfA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 ILE A6123
VAL A6298
ALA A6209
ILE A6221
LEU A6216
 None
 1.01A 3w67C-4opfA:
undetectable		 3w67C-4opfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4opf NRPS/PKS
(Streptomyces
albus) 		3 / 3 GLN A6250
ASP A6192
GLN A6194
 None
 0.90A 4aztA-4opfA:
undetectable		 4aztA-4opfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6198
VAL A6223
GLY A6218
PHE A6261
THR A6202
 None
 1.37A 4mubA-4opfA:
undetectable		 4mubA-4opfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 9 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 0.98A 4q1wA-4opfA:
undetectable		 4q1wA-4opfA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 ALA A6338
LEU A6344
ARG A6465
ALA A6455
LEU A6138
 None
 1.16A 4qrcA-4opfA:
undetectable		 4qrcA-4opfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6197
GLU A6452
GLY A6342
GLU A6200
PHE A6132
 None
 1.29A 4retA-4opfA:
undetectable		 4retA-4opfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6197
GLU A6452
GLY A6342
GLU A6200
PHE A6132
 None
 1.29A 4retC-4opfA:
undetectable		 4retC-4opfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 7 ILE A6469
THR A6408
ILE A6406
LEU A6489
 None
 0.81A 5fukA-4opfA:
undetectable
5fukB-4opfA:
undetectable		 5fukA-4opfA:
21.38
5fukB-4opfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 11 LEU A6138
TYR A6141
GLY A6340
ILE A6458
VAL A6343
 None
 1.25A 5hjiA-4opfA:
undetectable		 5hjiA-4opfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		4 / 7 GLY A6514
PHE A6510
SER A6275
ARG A6373
 None
 1.02A 5n5dB-4opfA:
undetectable		 5n5dB-4opfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4opf NRPS/PKS
(Streptomyces
albus) 		3 / 3 LYS A6442
PRO A6443
LYS A6326
 None
 1.31A 5y9yA-4opfA:
undetectable		 5y9yA-4opfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 ILE A6123
ALA A6124
ALA A6352
HIS A6282
LEU A6281
 None
 0.97A 6a5zL-4opfA:
undetectable		 6a5zL-4opfA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 ILE A6123
ALA A6124
ALA A6352
HIS A6282
LEU A6281
 None
 1.03A 6a60D-4opfA:
undetectable		 6a60D-4opfA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6203
HIS A6180
GLY A6179
HIS A6182
PHE A6261
 None
 1.46A 6aphA-4opfA:
undetectable		 6aphA-4opfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 GLY A6226
ALA A6277
VAL A6457
VAL A6297
ILE A6454
 None
 0.74A 6dh6A-4opfA:
undetectable		 6dh6A-4opfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6257
ALA A6205
ASP A6208
ILE A6454
VAL A6223
 None
 0.97A 6dilA-4opfA:
undetectable		 6dilA-4opfA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6203
HIS A6180
GLY A6179
HIS A6182
PHE A6261
 None
 1.50A 6gbnA-4opfA:
undetectable		 6gbnA-4opfA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4opf NRPS/PKS
(Streptomyces
albus) 		5 / 12 LEU A6203
HIS A6180
GLY A6179
HIS A6182
PHE A6261
 None
 1.49A 6gbnB-4opfA:
undetectable		 6gbnB-4opfA:
24.10