SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ops'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 ILE A 365
ARG A 287
THR A 335
LEU A 334
 None
 1.03A 3ag1N-4opsA:
undetectable
3ag1W-4opsA:
undetectable		 3ag1N-4opsA:
20.38
3ag1W-4opsA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 LEU A 491
VAL A 497
VAL A 229
PHE A 487
 None
 1.11A 3soaA-4opsA:
undetectable		 3soaA-4opsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 TYR A 514
TRP A 457
PHE A 515
PHE A 477
 None
 1.40A 4awuA-4opsA:
undetectable		 4awuA-4opsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		5 / 11 VAL A 472
PHE A 487
LEU A 527
VAL A 521
THR A 268
 None
 1.45A 4eilE-4opsA:
undetectable		 4eilE-4opsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		4 / 5 GLY A 354
THR A 323
VAL A 351
ASP A 355
 None
 0.97A 4eohA-4opsA:
undetectable		 4eohA-4opsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ops MAJOR CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ASP A 450
VAL A 404
ASN A 239
 None
 0.79A 4lmnA-4opsA:
undetectable		 4lmnA-4opsA:
19.60