SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4opw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 11 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.07A 1fkfA-4opwA:
undetectable		 1fkfA-4opwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.00A 1fklA-4opwA:
undetectable		 1fklA-4opwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 11 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.08A 1tcoC-4opwA:
undetectable		 1tcoC-4opwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		4 / 7 LEU A 166
ALA A 188
LEU A 151
VAL A 211
 None
 0.88A 1tyrB-4opwA:
undetectable		 1tyrB-4opwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 11 LEU A 108
LEU A 130
LEU A 151
ILE A  44
VAL A 140
 None
 1.21A 2qd3A-4opwA:
undetectable		 2qd3A-4opwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 10 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.14A 3ihzA-4opwA:
undetectable		 3ihzA-4opwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ALA A 207
ALA A 188
THR A 168
ASN A 187
LEU A 130
 EDO  A 302 (-3.3A)
None
None
None
None
 1.13A 3r9cA-4opwA:
undetectable		 3r9cA-4opwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 LEU A 108
LEU A 130
LEU A 151
ILE A  44
VAL A 140
 None
 1.20A 4f4dA-4opwA:
undetectable		 4f4dA-4opwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 10 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.13A 4nnrB-4opwA:
undetectable		 4nnrB-4opwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.11A 5b8iC-4opwA:
undetectable		 5b8iC-4opwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		4 / 5 LEU A 166
ALA A 188
LEU A 151
VAL A 211
 None
 1.00A 5cr1A-4opwA:
undetectable		 5cr1A-4opwA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ASP A  23
ALA A  91
PRO A  73
GLY A  27
THR A  97
 None
 1.39A 5hfjA-4opwA:
undetectable		 5hfjA-4opwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 11 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.15A 5hw8D-4opwA:
undetectable		 5hw8D-4opwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		3 / 3 VAL A 155
GLN A 141
CYH A 138
 None
 0.83A 5icxC-4opwA:
undetectable
5icxF-4opwA:
undetectable		 5icxC-4opwA:
20.16
5icxF-4opwA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		4 / 5 ALA A 117
VAL A 140
PHE A  46
ILE A 132
 None
 0.97A 5of1B-4opwA:
undetectable		 5of1B-4opwA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.10A 6mkeA-4opwA:
undetectable
6mkeD-4opwA:
undetectable		 6mkeA-4opwA:
17.30
6mkeD-4opwA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4opw UNCHARACTERIZED
PROTEIN
(Parabacteroides
merdae) 		5 / 12 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.12A 6mkeB-4opwA:
undetectable
6mkeC-4opwA:
undetectable		 6mkeB-4opwA:
17.30
6mkeC-4opwA:
17.30