SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 7 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.52A 1dmaA-4oqaC:
5.4		 1dmaA-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 6 HIS C 862
GLY C 863
TYR C 896
ALA C 898
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.40A 1dmaB-4oqaC:
5.9		 1dmaB-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 12 LEU C 698
ILE C 643
THR C 556
HIS C 742
LEU C 768
 None
 1.07A 2jn3A-4oqaC:
0.9		 2jn3A-4oqaC:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		3 / 3 GLY C 863
TYR C 907
SER C 904
 2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
 0.66A 2xatA-4oqaC:
undetectable		 2xatA-4oqaC:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 4 GLU A  76
ASP A 285
ASP A 307
TYR A 309
 None
 1.50A 2yvlA-4oqaA:
undetectable		 2yvlA-4oqaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 12 GLY C 871
ILE C 895
HIS C 862
LEU C 920
LEU C 999
 None
None
2US  C1101 (-3.7A)
None
None
 1.05A 3cs8A-4oqaC:
undetectable		 3cs8A-4oqaC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.38A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.88A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 0.94A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.52A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.84A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 8 HIS C 862
GLY C 863
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.44A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.55A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 8 HIS C 862
GLY C 863
TYR C 896
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 1.01A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 12 MET C 696
LEU C 701
LEU C 641
HIS C 742
VAL C 560
 None
 1.36A 3w1wB-4oqaC:
undetectable		 3w1wB-4oqaC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 5 HIS C 826
SER C 902
SER C 904
VAL C 901
 None
None
2US  C1101 (-3.4A)
None
 1.47A 4a99D-4oqaC:
undetectable		 4a99D-4oqaC:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 6 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.53A 4ae1A-4oqaC:
6.3		 4ae1A-4oqaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 5 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.50A 4ae1B-4oqaC:
4.8		 4ae1B-4oqaC:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.36A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.81A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 0.93A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.44A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 6 MET A  38
TRP A  51
GLU A  12
ARG A  34
 None
 1.43A 4bqfA-4oqaA:
undetectable		 4bqfA-4oqaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 12 LYS C1004
THR C 866
ASP C 791
VAL C 669
GLN C 670
 None
 1.07A 4df3A-4oqaC:
undetectable		 4df3A-4oqaC:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		3 / 3 TYR C 634
THR C 632
GLU C 619
 None
 0.78A 4df3A-4oqaC:
undetectable		 4df3A-4oqaC:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		3 / 3 TYR C 634
THR C 632
GLU C 619
 None
 0.76A 4df3B-4oqaC:
undetectable		 4df3B-4oqaC:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 8 THR C 867
GLY C 871
ARG C 878
VAL C 773
 None
 0.97A 4e1vG-4oqaC:
undetectable		 4e1vG-4oqaC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 7 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.66A 4hyfA-4oqaC:
19.7		 4hyfA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 0.89A 4hyfB-4oqaC:
19.8		 4hyfB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.66A 4hyfB-4oqaC:
19.8		 4hyfB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		8 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.62A 4hyfC-4oqaC:
19.8		 4hyfC-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 7 ASN C 767
MET C 686
GLU C 688
GLU C 763
 None
 1.29A 4r87I-4oqaC:
undetectable		 4r87I-4oqaC:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		10 / 11 GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.57A 4rv6A-4oqaC:
47.9		 4rv6A-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 11 GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.86A 4rv6A-4oqaC:
47.9		 4rv6A-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		10 / 11 GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.57A 4rv6B-4oqaC:
48.1		 4rv6B-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 11 GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.87A 4rv6B-4oqaC:
48.1		 4rv6B-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 9 ASP C 770
SER C 864
ASN C 868
ILE C 872
SER C 904
TYR C 907
 None
None
None
None
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.86A 5ha9B-4oqaC:
46.1		 5ha9B-4oqaC:
86.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 9 HIS C 862
SER C 864
ASN C 868
ILE C 872
TYR C 896
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
None
None
None
2US  C1101 (-4.2A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.47A 5ha9B-4oqaC:
46.1		 5ha9B-4oqaC:
86.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 11 ARG C 857
GLY C 922
ASN C 998
ASP C 993
VAL C 991
 None
 1.36A 5hjiA-4oqaC:
undetectable		 5hjiA-4oqaC:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 8 ASN C 767
ARG C 865
HIS C 909
GLU C 688
 None
 0.85A 6b94A-4oqaC:
undetectable		 6b94A-4oqaC:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 6 LEU C 797
VAL C 833
PHE C 677
GLY C 871
 None
 0.88A 6hd4B-4oqaC:
undetectable		 6hd4B-4oqaC:
10.53