SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.12A 1dz4A-4oqfA:
undetectable		 1dz4A-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.15A 1dz4B-4oqfA:
undetectable		 1dz4B-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 242
GLY A 273
ASP A 277
 None
 0.51A 1kf6A-4oqfA:
3.1
1kf6B-4oqfA:
undetectable		 1kf6A-4oqfA:
19.24
1kf6B-4oqfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 THR A  43
LEU A  57
VAL A 222
VAL A 226
 None
 1.06A 1o76B-4oqfA:
undetectable		 1o76B-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.80A 1v54N-4oqfA:
undetectable
1v54W-4oqfA:
undetectable		 1v54N-4oqfA:
20.15
1v54W-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 THR A  43
LEU A  57
VAL A 222
VAL A 226
 None
 1.04A 1yrdA-4oqfA:
undetectable		 1yrdA-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 275
ASP A  49
ILE A  46
GLY A  44
GLY A 268
 None
EDO  A 403 (-3.6A)
EDO  A 403 ( 4.3A)
EDO  A 403 (-3.2A)
None
 1.12A 1zz1C-4oqfA:
4.8		 1zz1C-4oqfA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.84A 2dyrN-4oqfA:
undetectable
2dyrW-4oqfA:
undetectable		 2dyrN-4oqfA:
20.15
2dyrW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.81A 2eilN-4oqfA:
undetectable
2eilW-4oqfA:
undetectable		 2eilN-4oqfA:
20.15
2eilW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.78A 2einN-4oqfA:
undetectable
2einW-4oqfA:
undetectable		 2einN-4oqfA:
20.15
2einW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  51
ALA A  47
ALA A 259
VAL A 247
GLY A  56
 None
 1.04A 2f16K-4oqfA:
undetectable
2f16L-4oqfA:
undetectable		 2f16K-4oqfA:
22.35
2f16L-4oqfA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  51
ALA A  47
ALA A 259
VAL A 247
GLY A  56
 None
 1.03A 2f16Y-4oqfA:
undetectable
2f16Z-4oqfA:
undetectable		 2f16Y-4oqfA:
22.35
2f16Z-4oqfA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 THR A  43
LEU A  57
VAL A 222
VAL A 226
 None
 1.08A 2feuA-4oqfA:
undetectable		 2feuA-4oqfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 277
ASP A 262
GLU A 230
LEU A 232
 None
 1.10A 2q0iA-4oqfA:
undetectable		 2q0iA-4oqfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.20A 2zawA-4oqfA:
undetectable		 2zawA-4oqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 THR A  43
LEU A  57
VAL A 222
VAL A 226
 None
 1.07A 2zuiA-4oqfA:
undetectable		 2zuiA-4oqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.83A 3ablA-4oqfA:
undetectable
3ablJ-4oqfA:
undetectable		 3ablA-4oqfA:
20.15
3ablJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.78A 3ablN-4oqfA:
undetectable
3ablW-4oqfA:
undetectable		 3ablN-4oqfA:
20.15
3ablW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.70A 3ag1N-4oqfA:
undetectable
3ag1W-4oqfA:
undetectable		 3ag1N-4oqfA:
20.15
3ag1W-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.09A 3fwgA-4oqfA:
undetectable		 3fwgA-4oqfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.84A 3wg7N-4oqfA:
undetectable
3wg7W-4oqfA:
undetectable		 3wg7N-4oqfA:
20.15
3wg7W-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.11A 3wrhE-4oqfA:
undetectable		 3wrhE-4oqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.10A 3wrjE-4oqfA:
undetectable		 3wrjE-4oqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  62
LEU A 216
LEU A 176
ILE A 144
 None
 0.87A 4a9jB-4oqfA:
undetectable		 4a9jB-4oqfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.11A 4ek1A-4oqfA:
undetectable		 4ek1A-4oqfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.13A 4g3rA-4oqfA:
undetectable		 4g3rA-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
VAL A  81
VAL A 117
ASP A  95
 None
 1.13A 4g3rB-4oqfA:
undetectable		 4g3rB-4oqfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  51
ALA A  47
ALA A 259
VAL A 247
GLY A  56
 None
 0.84A 4qvyK-4oqfA:
undetectable
4qvyL-4oqfA:
undetectable		 4qvyK-4oqfA:
22.35
4qvyL-4oqfA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  51
ALA A  47
ALA A 259
VAL A 247
GLY A  56
 None
 0.84A 4qvyY-4oqfA:
undetectable
4qvyZ-4oqfA:
undetectable		 4qvyY-4oqfA:
22.35
4qvyZ-4oqfA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.35A 4v2yA-4oqfA:
undetectable		 4v2yA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.37A 4v2yB-4oqfA:
undetectable		 4v2yB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.32A 4v2yC-4oqfA:
undetectable		 4v2yC-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.36A 4v2zA-4oqfA:
undetectable		 4v2zA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.38A 4v2zB-4oqfA:
undetectable		 4v2zB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.37A 4v2zC-4oqfA:
undetectable		 4v2zC-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.38A 4v30A-4oqfA:
undetectable		 4v30A-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  52
ALA A  47
VAL A  76
ILE A 269
 None
 0.94A 4xe3A-4oqfA:
undetectable		 4xe3A-4oqfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  66
ILE A 193
GLY A  72
THR A 243
 EDO  A 402 (-4.8A)
None
GOL  A 401 (-3.4A)
None
 0.84A 4ze3A-4oqfA:
undetectable		 4ze3A-4oqfA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 10 MET A 179
LEU A 176
LEU A 127
GLY A 212
GLN A 168
 None
 1.39A 4zp0A-4oqfA:
undetectable		 4zp0A-4oqfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.30A 5amhA-4oqfA:
undetectable		 5amhA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.39A 5amiA-4oqfA:
undetectable		 5amiA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.40A 5amiB-4oqfA:
undetectable		 5amiB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.34A 5amjA-4oqfA:
undetectable		 5amjA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.38A 5amjB-4oqfA:
undetectable		 5amjB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.42A 5amkA-4oqfA:
undetectable		 5amkA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.32A 5amkB-4oqfA:
undetectable		 5amkB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5b1bA-4oqfA:
undetectable
5b1bJ-4oqfA:
undetectable		 5b1bA-4oqfA:
20.15
5b1bJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.83A 5b1bN-4oqfA:
undetectable
5b1bW-4oqfA:
undetectable		 5b1bN-4oqfA:
20.15
5b1bW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5b3sN-4oqfA:
undetectable
5b3sW-4oqfA:
undetectable		 5b3sN-4oqfA:
20.15
5b3sW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 TYR A  66
ILE A 193
GLY A  72
THR A 243
 EDO  A 402 (-4.8A)
None
GOL  A 401 (-3.4A)
None
 0.82A 5esjA-4oqfA:
undetectable		 5esjA-4oqfA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  66
ILE A 193
GLY A  72
THR A 243
 EDO  A 402 (-4.8A)
None
GOL  A 401 (-3.4A)
None
 0.83A 5esmA-4oqfA:
undetectable		 5esmA-4oqfA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.80A 5iy5A-4oqfA:
undetectable
5iy5J-4oqfA:
undetectable		 5iy5A-4oqfA:
20.15
5iy5J-4oqfA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.79A 5iy5N-4oqfA:
undetectable
5iy5W-4oqfA:
undetectable		 5iy5N-4oqfA:
20.15
5iy5W-4oqfA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 171
MET A 179
LEU A 176
PRO A 120
ALA A  96
 None
 1.30A 5og9A-4oqfA:
undetectable		 5og9A-4oqfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.36A 5oh3A-4oqfA:
undetectable		 5oh3A-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.40A 5oh3B-4oqfA:
undetectable		 5oh3B-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
PHE A 192
ILE A  94
ALA A  92
GLY A  60
 None
 1.03A 5veuA-4oqfA:
undetectable		 5veuA-4oqfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
PHE A 192
ILE A  94
ALA A  92
GLY A  60
 None
 1.05A 5veuH-4oqfA:
undetectable		 5veuH-4oqfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.95A 5xdqA-4oqfA:
undetectable
5xdqJ-4oqfA:
undetectable		 5xdqA-4oqfA:
20.15
5xdqJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5xdxN-4oqfA:
undetectable
5xdxW-4oqfA:
undetectable		 5xdxN-4oqfA:
20.15
5xdxW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.81A 5z86N-4oqfA:
undetectable
5z86W-4oqfA:
undetectable		 5z86N-4oqfA:
20.15
5z86W-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.81A 5zcoA-4oqfA:
undetectable
5zcoJ-4oqfA:
undetectable		 5zcoA-4oqfA:
20.15
5zcoJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.81A 5zcoN-4oqfA:
undetectable
5zcoW-4oqfA:
undetectable		 5zcoN-4oqfA:
20.15
5zcoW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5zcqN-4oqfA:
undetectable
5zcqW-4oqfA:
undetectable		 5zcqN-4oqfA:
20.15
5zcqW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.63A 6nmfA-4oqfA:
undetectable
6nmfJ-4oqfA:
undetectable		 6nmfA-4oqfA:
20.15
6nmfJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oqf PROTEIN RECA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.73A 6nmpA-4oqfA:
undetectable
6nmpJ-4oqfA:
undetectable		 6nmpA-4oqfA:
20.15
6nmpJ-4oqfA:
12.07