SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 7 TYR A 227
PHE A 235
GLY A 239
GLY A 250
 None
 0.70A 11gsB-4oqjA:
undetectable		 11gsB-4oqjA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 ALA A 524
ARG A 511
LEU A 691
LEU A 466
LEU A 493
 None
 1.33A 1eiiA-4oqjA:
undetectable		 1eiiA-4oqjA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4oqj PKS
(Streptomyces
albus) 		6 / 12 ALA A 200
LEU A 262
ALA A 212
VAL A 430
ILE A 443
HIS A 441
 None
 1.48A 1fm6U-4oqjA:
undetectable		 1fm6U-4oqjA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4oqj PKS
(Streptomyces
albus) 		4 / 4 GLY A 503
LEU A 502
GLY A 119
ARG A 688
 None
 0.99A 1j7kA-4oqjA:
undetectable		 1j7kA-4oqjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		4 / 4 ILE A 665
LEU A 664
VAL A 545
ALA A 616
 None
 1.00A 1mz9A-4oqjA:
undetectable		 1mz9A-4oqjA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 LEU A 493
ALA A 515
VAL A 496
LEU A 691
LEU A 481
 None
 1.14A 1rlbF-4oqjA:
undetectable		 1rlbF-4oqjA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 THR A 381
LEU A 385
ILE A 382
VAL A  22
TRP A 419
 None
 1.35A 1wsvA-4oqjA:
undetectable		 1wsvA-4oqjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 215
TYR A 132
CYH A 110
ALA A 259
ALA A 114
 None
 1.02A 2bm9A-4oqjA:
undetectable		 2bm9A-4oqjA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 215
TYR A 132
CYH A 110
ALA A 259
ALA A  26
 None
 1.12A 2bm9D-4oqjA:
undetectable		 2bm9D-4oqjA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 LEU A 547
LEU A 649
ALA A 594
ILE A 633
LEU A 630
 None
 1.13A 2jn3A-4oqjA:
undetectable		 2jn3A-4oqjA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 ALA A 376
GLY A 327
GLY A 367
ALA A 325
LEU A 341
 None
 1.04A 2plwA-4oqjA:
undetectable		 2plwA-4oqjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		4 / 7 VAL A 362
ALA A 376
PHE A 244
THR A 251
 None
 1.03A 2q6oA-4oqjA:
undetectable		 2q6oA-4oqjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 SER A 203
TYR A 132
LEU A 177
THR A 282
 None
 0.93A 2v0zO-4oqjA:
undetectable		 2v0zO-4oqjA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 ARG A 505
ARG A 124
PRO A 122
 None
 1.08A 2wljA-4oqjA:
undetectable		 2wljA-4oqjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		6 / 12 ILE A 336
ALA A 325
GLY A 327
THR A 328
GLY A 333
THR A 381
 None
None
None
GOL  A 903 ( 3.7A)
None
None
 1.23A 2y7hC-4oqjA:
undetectable		 2y7hC-4oqjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4oqj PKS
(Streptomyces
albus) 		4 / 5 VAL A 169
THR A 371
THR A 173
ARG A 172
 None
 1.15A 3bjwA-4oqjA:
undetectable		 3bjwA-4oqjA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 258
GLY A 215
GLY A 134
LEU A  25
PHE A  38
 None
 0.92A 3elwA-4oqjA:
undetectable		 3elwA-4oqjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 ALA A 376
GLY A 256
VAL A 257
GLY A 258
VAL A 366
 None
 1.15A 3f8wA-4oqjA:
undetectable		 3f8wA-4oqjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 ALA A 376
GLY A 256
VAL A 257
GLY A 258
VAL A 366
 None
 1.18A 3f8wC-4oqjA:
undetectable		 3f8wC-4oqjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		4 / 4 LEU A 269
ALA A  21
VAL A 278
PRO A 447
 None
 1.00A 3gv1B-4oqjA:
undetectable		 3gv1B-4oqjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 CYH A 574
PRO A 581
ASP A 592
 None
 0.86A 3hlwB-4oqjA:
undetectable		 3hlwB-4oqjA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 PHE A 567
TYR A 561
ALA A 600
ALA A 596
 None
 0.96A 3l4dD-4oqjA:
undetectable		 3l4dD-4oqjA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 LEU A  42
ILE A 379
GLY A 377
ALA A 376
LEU A 369
 None
 1.11A 3n8yA-4oqjA:
undetectable		 3n8yA-4oqjA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 TYR A 227
PHE A 235
GLY A 239
GLY A 250
 None
 0.73A 3n9jB-4oqjA:
undetectable		 3n9jB-4oqjA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 5 GLN A 106
ARG A 105
GLU A 109
PHE A  90
 None
 1.47A 3py4A-4oqjA:
0.0		 3py4A-4oqjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 PRO A 695
ALA A 477
THR A 478
LEU A 481
LEU A 513
 None
 1.14A 3r9cA-4oqjA:
undetectable		 3r9cA-4oqjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 434
GLY A 374
SER A 432
ALA A 325
SER A 393
 GOL  A 903 ( 4.0A)
None
None
None
None
 1.20A 3sueD-4oqjA:
undetectable		 3sueD-4oqjA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 5 LEU A 177
ARG A 172
ILE A 100
ARG A 105
 None
 1.31A 3ticA-4oqjA:
undetectable		 3ticA-4oqjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 ASN A 255
GLN A  77
ASN A 365
THR A 364
 None
 1.42A 4d1yA-4oqjA:
undetectable
4d1yB-4oqjA:
undetectable		 4d1yA-4oqjA:
12.05
4d1yB-4oqjA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 10 GLY A 672
ALA A 671
GLY A 666
ILE A 665
VAL A 545
 None
 0.97A 4dqeB-4oqjA:
undetectable		 4dqeB-4oqjA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4oqj PKS
(Streptomyces
albus) 		5 / 10 PHE A 660
ALA A 564
LEU A 560
GLY A 657
ALA A 626
 None
 1.32A 4fe1A-4oqjA:
undetectable
4fe1J-4oqjA:
undetectable		 4fe1A-4oqjA:
24.45
4fe1J-4oqjA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 HIS A 240
ALA A  75
TYR A 227
SER A 236
 None
 1.03A 4k0bB-4oqjA:
undetectable		 4k0bB-4oqjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 GLY A 367
GLU A  47
THR A  48
 None
 0.58A 4kouA-4oqjA:
undetectable		 4kouA-4oqjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4oqj PKS
(Streptomyces
albus) 		5 / 9 PHE A 660
ALA A 564
LEU A 560
GLY A 657
ALA A 626
 None
 1.28A 4l6va-4oqjA:
undetectable
4l6vf-4oqjA:
undetectable		 4l6va-4oqjA:
22.92
4l6vf-4oqjA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4oqj PKS
(Streptomyces
albus) 		4 / 8 HIS A 240
ALA A  75
TYR A 227
SER A 236
 None
 1.01A 4l7iB-4oqjA:
undetectable		 4l7iB-4oqjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4oqj PKS
(Streptomyces
albus) 		6 / 12 ALA A 189
CYH A 190
HIS A 326
THR A 328
HIS A 368
GLY A 434
 None
GOL  A 903 (-2.8A)
GOL  A 903 (-3.8A)
GOL  A 903 ( 3.7A)
GOL  A 903 (-3.8A)
GOL  A 903 ( 4.0A)
 0.65A 4ls7A-4oqjA:
46.7		 4ls7A-4oqjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4oqj PKS
(Streptomyces
albus) 		6 / 12 ALA A 189
CYH A 190
HIS A 326
THR A 328
HIS A 368
GLY A 434
 None
GOL  A 903 (-2.8A)
GOL  A 903 (-3.8A)
GOL  A 903 ( 3.7A)
GOL  A 903 (-3.8A)
GOL  A 903 ( 4.0A)
 0.63A 4ls7A-4oqjA:
46.7
4ls7B-4oqjA:
46.5		 4ls7A-4oqjA:
18.05
4ls7B-4oqjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 VAL A 195
ALA A 196
SER A 185
GLY A 134
THR A 438
 None
 1.22A 4mmaA-4oqjA:
undetectable		 4mmaA-4oqjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4oqj PKS
(Streptomyces
albus) 		4 / 4 HIS A 198
ALA A 283
VAL A 284
GLU A 308
 None
 1.32A 4n6pA-4oqjA:
undetectable		 4n6pA-4oqjA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 CYH A 574
PRO A 581
ASP A 592
 None
 0.80A 4pm5A-4oqjA:
undetectable		 4pm5A-4oqjA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 GLY A 316
PRO A 317
ALA A 344
 None
 0.39A 4qn9B-4oqjA:
undetectable		 4qn9B-4oqjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oqj PKS
(Streptomyces
albus) 		5 / 9 ALA A 372
THR A 371
ALA A 216
VAL A 366
GLY A 254
 None
 1.17A 4qvnK-4oqjA:
undetectable
4qvnL-4oqjA:
undetectable		 4qvnK-4oqjA:
13.52
4qvnL-4oqjA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4oqj PKS
(Streptomyces
albus) 		5 / 9 ALA A 372
THR A 371
ALA A 216
VAL A 366
GLY A 254
 None
 1.17A 4qvnY-4oqjA:
undetectable
4qvnZ-4oqjA:
undetectable		 4qvnY-4oqjA:
13.52
4qvnZ-4oqjA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 ALA A 200
ALA A  21
ILE A  20
ILE A 382
LEU A 378
 None
 0.99A 4r3aB-4oqjA:
undetectable		 4r3aB-4oqjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 588
GLY A 552
GLY A 551
ALA A 583
ASP A 592
 None
 0.99A 5c0oF-4oqjA:
undetectable		 5c0oF-4oqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4oqj PKS
(Streptomyces
albus) 		6 / 12 GLY A 367
GLY A 254
GLY A  76
LEU A  49
ALA A 373
GLU A 324
 None
 1.33A 5c0oG-4oqjA:
undetectable		 5c0oG-4oqjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 374
GLY A 429
GLY A 377
VAL A 320
ILE A 443
 None
 1.08A 5ehiC-4oqjA:
undetectable		 5ehiC-4oqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4oqj PKS
(Streptomyces
albus) 		4 / 6 GLU A 446
ARG A 426
ARG A 386
ARG A 388
 None
 1.00A 5l6eA-4oqjA:
undetectable
5l6eB-4oqjA:
undetectable		 5l6eA-4oqjA:
11.57
5l6eB-4oqjA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 ALA A 602
THR A 601
ALA A 600
GLY A 607
ALA A 606
 None
 1.00A 5lf3K-4oqjA:
undetectable
5lf3L-4oqjA:
undetectable		 5lf3K-4oqjA:
12.95
5lf3L-4oqjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 ALA A 602
THR A 601
ALA A 600
GLY A 607
ALA A 606
 None
 1.00A 5lf3Y-4oqjA:
undetectable
5lf3Z-4oqjA:
undetectable		 5lf3Y-4oqjA:
12.95
5lf3Z-4oqjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 PHE A  52
ALA A  75
ALA A 259
ALA A 216
THR A 371
 None
 1.16A 5tl8A-4oqjA:
undetectable		 5tl8A-4oqjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 437
PRO A 297
ALA A 296
ASP A 287
THR A 438
 None
 1.20A 5x6yC-4oqjA:
undetectable		 5x6yC-4oqjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 MET A 211
ASP A 273
ARG A 504
 None
 0.70A 5z6jA-4oqjA:
undetectable		 5z6jA-4oqjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 MET A 211
ASP A 273
ARG A 504
 None
 0.88A 5z6kA-4oqjA:
undetectable		 5z6kA-4oqjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4oqj PKS
(Streptomyces
albus) 		5 / 9 VAL A 675
VAL A 465
GLY A 503
LEU A 502
VAL A 506
 None
 1.21A 6czmB-4oqjA:
undetectable
6czmC-4oqjA:
undetectable		 6czmB-4oqjA:
20.09
6czmC-4oqjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4oqj PKS
(Streptomyces
albus) 		5 / 10 VAL A 675
VAL A 465
GLY A 503
LEU A 502
VAL A 506
 None
 1.21A 6czmE-4oqjA:
undetectable
6czmF-4oqjA:
undetectable		 6czmE-4oqjA:
20.09
6czmF-4oqjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 672
ALA A 671
GLY A 666
ILE A 665
VAL A 545
 None
 0.85A 6dj1B-4oqjA:
undetectable		 6dj1B-4oqjA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 12 GLY A 672
ALA A 671
GLY A 666
ILE A 665
VAL A 545
 None
 0.86A 6dj2B-4oqjA:
undetectable		 6dj2B-4oqjA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4oqj PKS
(Streptomyces
albus) 		3 / 3 LEU A 622
LEU A 630
ARG A 619
 None
 0.68A 6fgcA-4oqjA:
undetectable		 6fgcA-4oqjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 ALA A 647
LEU A 648
THR A 601
ILE A 665
ALA A 612
 None
 1.24A 6h1lB-4oqjA:
undetectable		 6h1lB-4oqjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4oqj PKS
(Streptomyces
albus) 		5 / 11 THR A 282
VAL A 306
THR A 381
ILE A 382
VAL A 444
 None
 1.29A 6hcoA-4oqjA:
1.5
6hcoB-4oqjA:
0.0		 6hcoA-4oqjA:
21.39
6hcoB-4oqjA:
21.39