SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 290
VAL A 308
TRP A  48
 None
 0.92A 1av2A-4oqrA:
undetectable
1av2B-4oqrA:
undetectable		 1av2A-4oqrA:
3.20
1av2B-4oqrA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.95A 1av2C-4oqrA:
undetectable
1av2D-4oqrA:
undetectable		 1av2C-4oqrA:
3.20
1av2D-4oqrA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 GLU A 357
LEU A 353
LEU A 162
GLY A 163
 HEM  A 501 ( 4.9A)
None
None
None
 0.89A 1mt1H-4oqrA:
undetectable
1mt1K-4oqrA:
undetectable		 1mt1H-4oqrA:
14.88
1mt1K-4oqrA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 11 LEU A 275
GLY A 252
VAL A 397
LEU A 145
LEU A 266
 None
 1.33A 1mx1B-4oqrA:
undetectable		 1mx1B-4oqrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 LEU A 395
GLY A 250
VAL A 392
LEU A 279
LEU A 328
 None
 1.09A 1mx1E-4oqrA:
undetectable		 1mx1E-4oqrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 GLU A 357
LEU A 353
LEU A 162
GLY A 163
 HEM  A 501 ( 4.9A)
None
None
None
 0.88A 1n13H-4oqrA:
undetectable
1n13K-4oqrA:
undetectable		 1n13H-4oqrA:
14.88
1n13K-4oqrA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 LEU A 353
LEU A 162
GLY A 163
GLU A 357
 None
None
None
HEM  A 501 ( 4.9A)
 0.89A 1n13G-4oqrA:
undetectable
1n13J-4oqrA:
undetectable		 1n13G-4oqrA:
8.78
1n13J-4oqrA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 312
VAL A  50
ILE A  61
VAL A 315
ILE A 310
 None
 0.96A 1ohrB-4oqrA:
undetectable		 1ohrB-4oqrA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 290
VAL A 308
TRP A  48
 None
 0.90A 1w5uA-4oqrA:
undetectable
1w5uB-4oqrA:
undetectable		 1w5uA-4oqrA:
3.20
1w5uB-4oqrA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.93A 1w5uA-4oqrA:
undetectable
1w5uB-4oqrA:
undetectable		 1w5uA-4oqrA:
3.20
1w5uB-4oqrA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 LEU A 257
GLY A 252
LEU A 249
ARG A 384
PRO A 396
 None
 1.15A 1y4lA-4oqrA:
undetectable		 1y4lA-4oqrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 109
PHE A  94
LEU A 219
LEU A 225
ALA A 234
 None
HEM  A 501 (-4.8A)
None
None
None
 1.30A 2bxeA-4oqrA:
undetectable		 2bxeA-4oqrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 ASN A  67
ASN A  96
ILE A 236
THR A 286
 HEM  A 501 ( 4.8A)
None
2UO  A 502 (-4.1A)
2UO  A 502 ( 4.4A)
 1.08A 2hkkA-4oqrA:
undetectable		 2hkkA-4oqrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.98A 2izqC-4oqrA:
undetectable
2izqD-4oqrA:
undetectable		 2izqC-4oqrA:
3.20
2izqD-4oqrA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 LYS A  11
GLY A 311
LEU A 312
LEU A  33
SER A  37
 None
 1.29A 2nv4A-4oqrA:
undetectable		 2nv4A-4oqrA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 GLY A 311
ALA A 340
LEU A  14
LEU A 284
LEU A  33
 None
HEM  A 501 (-4.8A)
None
None
None
 1.04A 2nyuA-4oqrA:
undetectable		 2nyuA-4oqrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.00A 2qd5A-4oqrA:
undetectable		 2qd5A-4oqrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.03A 2qd5B-4oqrA:
undetectable		 2qd5B-4oqrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 ILE A 118
PHE A 113
ARG A 355
GLY A 350
 None
None
None
HEM  A 501 (-3.6A)
 0.85A 2vdbA-4oqrA:
undetectable		 2vdbA-4oqrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 GLY A 391
LEU A 256
GLY A 252
GLY A 250
LEU A 275
 None
 1.08A 2zbpA-4oqrA:
undetectable		 2zbpA-4oqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 5 ARG A  40
MET A  39
THR A  13
LEU A  14
 None
 1.34A 3ag2J-4oqrA:
undetectable		 3ag2J-4oqrA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 240
THR A 244
CYH A 348
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.1A)
HEM  A 501 (-2.4A)
 0.63A 3e4eA-4oqrA:
27.3		 3e4eA-4oqrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 240
THR A 244
CYH A 348
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.1A)
HEM  A 501 (-2.4A)
 0.55A 3e4eB-4oqrA:
31.8		 3e4eB-4oqrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 THR A  95
VAL A 239
THR A 244
VAL A 282
 2UO  A 502 (-4.0A)
2UO  A 502 ( 4.9A)
HEM  A 501 (-3.1A)
2UO  A 502 ( 4.4A)
 0.84A 3fwiA-4oqrA:
41.8		 3fwiA-4oqrA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 275
HIS A 338
GLU A 273
ILE A 281
LEU A 279
 None
 1.28A 3hy7B-4oqrA:
undetectable		 3hy7B-4oqrA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 HIS A 242
THR A 176
ASP A 214
LEU A 216
LEU A 235
 None
 1.24A 3lcvB-4oqrA:
undetectable		 3lcvB-4oqrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 MET A 248
LEU A 279
PRO A  26
TYR A 278
 None
 1.04A 3vkxA-4oqrA:
undetectable		 3vkxA-4oqrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 ALA A 271
THR A 129
VAL A 153
PHE A 149
 None
 0.81A 4ltwA-4oqrA:
2.4		 4ltwA-4oqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 11 LEU A 312
VAL A  50
ILE A  61
VAL A 315
ILE A 310
 None
 0.94A 4qgiB-4oqrA:
undetectable		 4qgiB-4oqrA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
 None
 1.31A 5ieoA-4oqrA:
undetectable		 5ieoA-4oqrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 ASP A 318
PRO A 319
PHE A 322
SER A 280
 None
 1.16A 5l1fC-4oqrA:
undetectable		 5l1fC-4oqrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 4 ASN A 247
SER A 181
ALA A 389
VAL A 282
 None
None
2UO  A 502 ( 4.1A)
2UO  A 502 ( 4.4A)
 0.96A 5nm5A-4oqrA:
undetectable		 5nm5A-4oqrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 ARG A 364
GLY A 361
THR A 129
GLU A 130
 None
 0.94A 5ny7A-4oqrA:
undetectable		 5ny7A-4oqrA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 GLN A 300
TRP A  48
VAL A 308
 None
 0.89A 6auuA-4oqrA:
undetectable		 6auuA-4oqrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4oqr CYP105AS1
(Amycolatopsis
orientalis) 		5 / 10 GLY A 217
ALA A 234
LEU A 162
GLY A 163
LEU A 276
 None
 1.37A 6hqbA-4oqrA:
undetectable
6hqbJ-4oqrA:
undetectable		 6hqbA-4oqrA:
12.11
6hqbJ-4oqrA:
7.00