SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 290
VAL A 308
TRP A  48
 None
 0.91A 1av2A-4oqsA:
undetectable
1av2B-4oqsA:
undetectable		 1av2A-4oqsA:
3.20
1av2B-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.96A 1av2C-4oqsA:
undetectable
1av2D-4oqsA:
undetectable		 1av2C-4oqsA:
3.20
1av2D-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.89A 1c4dC-4oqsA:
undetectable
1c4dD-4oqsA:
undetectable		 1c4dC-4oqsA:
3.20
1c4dD-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 ALA A 234
SER A 210
ARG A 117
LEU A 237
 None
None
None
HEM  A 501 ( 4.5A)
 1.18A 1gahA-4oqsA:
undetectable		 1gahA-4oqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 10 LEU A 236
LEU A 235
ALA A 234
LEU A 162
LEU A 109
 HEM  A 501 ( 4.5A)
None
None
None
None
 1.32A 1gwrA-4oqsA:
undetectable		 1gwrA-4oqsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 11 PHE A 172
ILE A 200
ASN A 232
LEU A 193
GLY A 194
 None
 1.28A 1hvyC-4oqsA:
undetectable		 1hvyC-4oqsA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 11 PHE A 172
ILE A 200
ASN A 232
LEU A 193
GLY A 194
 None
 1.48A 1ju6D-4oqsA:
undetectable		 1ju6D-4oqsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 312
VAL A  50
ILE A  61
VAL A 315
ILE A 310
 None
 0.97A 1ohrB-4oqsA:
undetectable		 1ohrB-4oqsA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 PRO A 396
ALA A 378
GLU A 379
GLU A 380
 None
 1.20A 1qhyA-4oqsA:
undetectable		 1qhyA-4oqsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 ASP A 224
ASP A 222
ARG A 208
ALA A 234
ILE A 233
 None
 1.30A 1s14B-4oqsA:
undetectable		 1s14B-4oqsA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 290
VAL A 308
TRP A  48
 None
 0.90A 1w5uA-4oqsA:
undetectable
1w5uB-4oqsA:
undetectable		 1w5uA-4oqsA:
3.20
1w5uB-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 0.93A 1w5uA-4oqsA:
undetectable
1w5uB-4oqsA:
undetectable		 1w5uA-4oqsA:
3.20
1w5uB-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 237
LEU A 238
ILE A 158
PHE A 172
ILE A 200
 HEM  A 501 ( 4.5A)
None
None
None
None
 1.29A 2f7aA-4oqsA:
undetectable		 2f7aA-4oqsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 0.99A 2qd5A-4oqsA:
undetectable		 2qd5A-4oqsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.00A 2qd5B-4oqsA:
undetectable		 2qd5B-4oqsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 LEU A 236
VAL A 239
THR A 244
VAL A 282
 HEM  A 501 ( 4.5A)
None
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.8A)
 1.00A 2zaxA-4oqsA:
37.8		 2zaxA-4oqsA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 GLY A 391
LEU A 256
GLY A 252
GLY A 250
LEU A 275
 None
 1.07A 2zbpA-4oqsA:
undetectable		 2zbpA-4oqsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 VAL A 282
GLY A 241
SER A 155
GLN A 173
HIS A 242
 HEM  A 501 ( 4.8A)
HEM  A 501 (-3.2A)
None
None
None
 1.47A 2zthA-4oqsA:
undetectable		 2zthA-4oqsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 240
THR A 244
CYH A 348
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.49A 3e4eA-4oqsA:
29.4		 3e4eA-4oqsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ALA A 240
THR A 244
CYH A 348
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.44A 3e4eB-4oqsA:
29.5		 3e4eB-4oqsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 LEU A 236
VAL A 239
THR A 244
VAL A 282
 HEM  A 501 ( 4.5A)
None
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.8A)
 0.92A 3fwgB-4oqsA:
38.1		 3fwgB-4oqsA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 LEU A 236
VAL A 239
THR A 244
VAL A 282
 HEM  A 501 ( 4.5A)
None
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.8A)
 1.02A 3fwiA-4oqsA:
37.5		 3fwiA-4oqsA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 LEU A 275
HIS A 338
GLU A 273
ILE A 281
LEU A 279
 None
 1.30A 3hy7B-4oqsA:
undetectable		 3hy7B-4oqsA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 TRP A  48
ALA A 290
VAL A 308
 None
 1.00A 3l8lC-4oqsA:
undetectable
3l8lD-4oqsA:
undetectable		 3l8lC-4oqsA:
3.20
3l8lD-4oqsA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 GLU A 130
ARG A 364
THR A 363
ALA A 367
 None
 1.12A 3mbgA-4oqsA:
undetectable
3mbgB-4oqsA:
undetectable		 3mbgA-4oqsA:
14.99
3mbgB-4oqsA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 MET A 248
LEU A 279
PRO A  26
TYR A 278
 HEM  A 501 ( 4.5A)
None
None
None
 1.01A 3vkxA-4oqsA:
undetectable		 3vkxA-4oqsA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 PHE A 362
PHE A 366
ALA A 255
LEU A 330
 None
 0.90A 4ejgC-4oqsA:
29.4		 4ejgC-4oqsA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 ALA A 271
THR A 129
VAL A 153
PHE A 149
 None
 0.80A 4ltwA-4oqsA:
3.2		 4ltwA-4oqsA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OQR_A_2UOA502_1
(CYP105AS1)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 9 VAL A 239
ALA A 240
THR A 244
VAL A 282
ALA A 388
 None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.8A)
None
 0.77A 4oqrA-4oqsA:
56.2		 4oqrA-4oqsA:
86.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 11 LEU A 312
VAL A  50
ILE A  61
VAL A 315
ILE A 310
 None
 0.97A 4qgiB-4oqsA:
undetectable		 4qgiB-4oqsA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 4 ASN A 247
SER A 387
ALA A 389
VAL A 282
 None
None
None
HEM  A 501 ( 4.8A)
 1.13A 4x1kC-4oqsA:
undetectable		 4x1kC-4oqsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 6 ARG A 289
HIS A 102
ARG A 106
ILE A 345
 HEM  A 501 (-2.9A)
HEM  A 501 (-3.8A)
HEM  A 501 (-3.9A)
None
 1.42A 5a06A-4oqsA:
undetectable		 5a06A-4oqsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 ARG A 104
THR A 223
ASP A 224
 None
 0.93A 5g5gA-4oqsA:
undetectable
5g5gB-4oqsA:
undetectable		 5g5gA-4oqsA:
22.82
5g5gB-4oqsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
 None
 1.28A 5ieoA-4oqsA:
undetectable		 5ieoA-4oqsA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 4 GLN A 352
VAL A 356
GLU A 357
ILE A 125
 None
None
HEM  A 501 (-4.5A)
None
 1.33A 5jncA-4oqsA:
undetectable		 5jncA-4oqsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 7 ASP A 318
PRO A 319
PHE A 322
SER A 280
 None
 1.17A 5l1fC-4oqsA:
undetectable		 5l1fC-4oqsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		5 / 12 ASP A 187
GLU A 188
LEU A 235
LEU A 196
ALA A 192
 None
 1.15A 5nd7B-4oqsA:
undetectable		 5nd7B-4oqsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		4 / 8 GLY A 311
ILE A 310
ASP A 318
HIS A  53
 None
 1.02A 6ag0C-4oqsA:
undetectable		 6ag0C-4oqsA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oqs CYP105AS1
(Amycolatopsis
orientalis) 		3 / 3 GLN A 300
TRP A  48
VAL A 308
 None
 0.87A 6auuA-4oqsA:
undetectable		 6auuA-4oqsA:
21.37