SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 7 SER A  93
ASN A  91
ASP A  95
LYS A  99
 None
 1.34A 1hwiC-4oqyA:
undetectable		 1hwiC-4oqyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 7 SER A  93
ASN A  91
ASP A  95
LYS A  99
 None
 1.34A 1hwiD-4oqyA:
undetectable		 1hwiD-4oqyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 5 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NDP  A1000 (-4.9A)
 0.78A 2oiqA-4oqyA:
undetectable		 2oiqA-4oqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		5 / 11 ALA A 165
GLY A 118
TYR A 169
ALA A 103
TYR A  70
 None
 1.35A 3qxyB-4oqyA:
undetectable
3qxyQ-4oqyA:
undetectable		 3qxyB-4oqyA:
22.07
3qxyQ-4oqyA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 4 ALA A 100
ALA A 103
ALA A 104
ALA A 107
 None
 0.11A 4oadA-4oqyA:
undetectable		 4oadA-4oqyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 4 ALA A 100
ALA A 103
ALA A 104
ALA A 107
 None
 0.09A 4oaeA-4oqyA:
undetectable		 4oaeA-4oqyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 5 ARG A 101
GLY A 163
ALA A 162
PRO A  97
 None
 0.95A 4u9uA-4oqyA:
5.9		 4u9uA-4oqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		5 / 12 ALA A  90
LEU A 149
THR A 133
GLY A 137
PRO A 138
 None
 1.20A 4ypmA-4oqyA:
undetectable		 4ypmA-4oqyA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		5 / 12 GLY A  10
GLY A  12
ALA A  72
ILE A  76
ALA A  17
 NDP  A1000 (-3.4A)
NDP  A1000 (-3.7A)
NDP  A1000 (-3.5A)
None
None
 1.25A 5bw4B-4oqyA:
5.0		 5bw4B-4oqyA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		4 / 8 LEU A 285
LEU A 234
GLY A 268
ALA A 267
 None
 0.81A 5f1aA-4oqyA:
undetectable		 5f1aA-4oqyA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		5 / 12 ASP A  24
PHE A  22
GLY A  26
SER A   5
GLU A  28
 None
 1.25A 5hfjG-4oqyA:
2.5		 5hfjG-4oqyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		3 / 3 SER A 136
TYR A 135
TYR A 157
 None
 0.77A 5lakA-4oqyA:
undetectable
5lakI-4oqyA:
undetectable		 5lakA-4oqyA:
21.97
5lakI-4oqyA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		3 / 3 SER A 136
TYR A 135
TYR A 157
 None
 0.79A 5lakC-4oqyA:
undetectable
5lakJ-4oqyA:
undetectable		 5lakC-4oqyA:
21.97
5lakJ-4oqyA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4oqy (S)-IMINE REDUCTASE
(Streptomyces
sp.
GF3546) 		5 / 12 ALA A  17
GLY A  15
ALA A 155
SER A  66
VAL A 119
 None
None
None
NDP  A1000 ( 3.8A)
NDP  A1000 (-4.4A)
 0.92A 5w4zB-4oqyA:
undetectable		 5w4zB-4oqyA:
13.38