SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4or2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 672
ILE A 634
ILE A 633
GLU A 783
THR A 677
 None
 1.19A 1jtxA-4or2A:
1.6		 1jtxA-4or2A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 763
ASN A 760
LEU A 762
GLY A 761
MET A 791
 None
FM9  A1901 (-3.9A)
None
None
None
 1.30A 1p93A-4or2A:
undetectable		 1p93A-4or2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG A 661
SER A 673
TYR A 672
 None
 0.70A 1x70A-4or2A:
undetectable		 1x70A-4or2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PRO A1056
ASP A1060
TYR A1105
THR A 653
 None
None
None
CLR  A1905 (-3.4A)
 1.01A 2aouB-4or2A:
undetectable		 2aouB-4or2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASP A1073
LEU A1076
LYS A1077
ARG A1034
 None
 1.38A 2gj5A-4or2A:
undetectable		 2gj5A-4or2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A1010
LEU A1014
TRP A1007
ILE A1102
 None
 0.95A 2rlfB-4or2A:
undetectable
2rlfC-4or2A:
undetectable		 2rlfB-4or2A:
11.28
2rlfC-4or2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ILE A1102
ARG A1098
LEU A1068
LEU A1106
 None
 1.02A 2rlfA-4or2A:
undetectable
2rlfD-4or2A:
undetectable		 2rlfA-4or2A:
11.28
2rlfD-4or2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		3 / 3 VAL A 721
ASN A 760
TRP A 798
 None
FM9  A1901 (-3.9A)
None
 1.04A 2y00B-4or2A:
16.9		 2y00B-4or2A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ILE A 638
PHE A 639
GLY A 641
ILE A 597
 None
None
None
CLR  A1902 ( 4.6A)
 0.75A 4o8fB-4or2A:
undetectable		 4o8fB-4or2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A1097
GLY A1070
ALA A1037
HIS A1063
 None
 0.96A 5eevL-4or2A:
undetectable
5eevV-4or2A:
undetectable		 5eevL-4or2A:
12.35
5eevV-4or2A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A1097
GLY A1070
ALA A1037
HIS A1063
 None
 0.95A 5eewL-4or2A:
undetectable
5eewV-4or2A:
undetectable		 5eewL-4or2A:
12.35
5eewV-4or2A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A1097
GLY A1070
ALA A1037
HIS A1063
 None
 0.95A 5ef3L-4or2A:
undetectable
5ef3V-4or2A:
undetectable		 5ef3L-4or2A:
12.35
5ef3V-4or2A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 622
ILE A 787
ILE A 837
PHE A 614
PHE A 831
 None
 1.29A 6j20A-4or2A:
17.3		 6j20A-4or2A:
21.67