SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4or8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		5 / 12 LEU A  97
ALA A 101
LEU A 229
ALA A 227
ILE A  49
 None
 0.87A 1fk6A-4or8A:
undetectable		 1fk6A-4or8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		3 / 3 LEU A 122
TRP A  42
GLY A  43
 None
 0.75A 3l35B-4or8A:
undetectable
3l35K-4or8A:
undetectable		 3l35B-4or8A:
10.94
3l35K-4or8A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		5 / 11 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.34A 3tbgA-4or8A:
undetectable		 3tbgA-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		5 / 10 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.26A 3tbgC-4or8A:
undetectable		 3tbgC-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		5 / 9 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.17A 3tbgD-4or8A:
undetectable		 3tbgD-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		4 / 7 GLY A 196
VAL A 193
ILE A 190
PHE A 160
 None
 0.89A 4fglC-4or8A:
undetectable		 4fglC-4or8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24
(Marburg
marburgvirus) 		3 / 3 GLN A  71
ILE A  87
HIS A  58
 None
 0.68A 5z12B-4or8A:
undetectable		 5z12B-4or8A:
14.01