SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ora'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ILE A 312
GLN A 203
ILE A  94
PRO A  93
LEU A 200
 None
 1.11A 1dhfA-4oraA:
undetectable		 1dhfA-4oraA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 127
HIS A 160
HIS A 101
 ZN  A 601 ( 3.7A)
None
FE  A 602 (-3.9A)
 0.54A 1oe1A-4oraA:
undetectable		 1oe1A-4oraA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 127
HIS A 160
HIS A 101
 ZN  A 601 ( 3.7A)
None
FE  A 602 (-3.9A)
 0.53A 1oe3A-4oraA:
undetectable		 1oe3A-4oraA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_1
(SERINE/THREONINE
PHOSPHATASE B2
FK506-BINDING
PROTEIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 4 TRP A 361
SER A 362
PHE A 365
GLU A 368
 None
 0.49A 1tcoA-4oraA:
56.0		 1tcoA-4oraA:
84.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 300
GLY A  98
PHE A 315
SER A 316
 None
 1.31A 2a3cA-4oraA:
undetectable		 2a3cA-4oraA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 300
GLY A  98
PHE A 315
SER A 316
 None
 1.33A 2a3cB-4oraA:
undetectable		 2a3cB-4oraA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 127
HIS A 160
HIS A 101
 ZN  A 601 ( 3.7A)
None
FE  A 602 (-3.9A)
 0.57A 2xxgA-4oraA:
undetectable		 2xxgA-4oraA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 127
HIS A 160
HIS A 101
 ZN  A 601 ( 3.7A)
None
FE  A 602 (-3.9A)
 0.57A 2xxgC-4oraA:
undetectable		 2xxgC-4oraA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 TYR A 184
ASP A 130
HIS A 164
 None
 0.88A 3e23A-4oraA:
undetectable		 3e23A-4oraA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ASN A  57
HIS A  58
VAL A  65
 None
 0.80A 3elzB-4oraA:
undetectable		 3elzB-4oraA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 PHE A 171
ILE A  74
VAL A 183
CYH A 187
TYR A 179
 None
 1.28A 3p6gA-4oraA:
undetectable		 3p6gA-4oraA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		3 / 3 ARG A  82
PRO A 195
PHE A 227
 None
 0.98A 3thrC-4oraA:
undetectable		 3thrC-4oraA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  99
LEU A 311
ASN A 159
THR A 313
GLY A 158
 FE  A 602 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
None
 1.05A 3uq6A-4oraA:
undetectable		 3uq6A-4oraA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  99
LEU A 311
ASN A 159
THR A 313
GLY A 158
 FE  A 602 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
None
 1.08A 3uq6B-4oraA:
undetectable		 3uq6B-4oraA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  99
LEU A 311
ASN A 159
THR A 313
GLY A 158
 FE  A 602 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
None
 1.05A 3vaqA-4oraA:
undetectable		 3vaqA-4oraA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  99
LEU A 311
ASN A 159
THR A 313
GLY A 158
 FE  A 602 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
None
 1.10A 3vaqB-4oraA:
undetectable		 3vaqB-4oraA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  99
LEU A 311
ASN A 159
THR A 313
GLY A 158
 FE  A 602 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
None
 1.04A 3vasA-4oraA:
undetectable		 3vasA-4oraA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 CYH A  97
SER A 316
HIS A 101
LEU A 107
LEU A 153
 None
None
FE  A 602 (-3.9A)
None
None
 1.19A 3vn2A-4oraA:
undetectable		 3vn2A-4oraA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.15A 4feuB-4oraA:
undetectable		 4feuB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.18A 4feuB-4oraA:
undetectable		 4feuB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.14A 4feuF-4oraA:
undetectable		 4feuF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.17A 4feuF-4oraA:
undetectable		 4feuF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.14A 4fevD-4oraA:
undetectable		 4fevD-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.14A 4fevD-4oraA:
undetectable		 4fevD-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.11A 4fevF-4oraA:
undetectable		 4fevF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.15A 4fevF-4oraA:
undetectable		 4fevF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.15A 4fewD-4oraA:
undetectable		 4fewD-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.15A 4fewD-4oraA:
undetectable		 4fewD-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.13A 4fewF-4oraA:
undetectable		 4fewF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.15A 4fewF-4oraA:
undetectable		 4fewF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.12A 4fexB-4oraA:
undetectable		 4fexB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.15A 4fexB-4oraA:
undetectable		 4fexB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.04A 4gkhB-4oraA:
undetectable		 4gkhB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.07A 4gkhB-4oraA:
undetectable		 4gkhB-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.14A 4gkhF-4oraA:
undetectable		 4gkhF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.14A 4gkhF-4oraA:
undetectable		 4gkhF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.11A 4gkhG-4oraA:
undetectable		 4gkhG-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.13A 4gkhG-4oraA:
undetectable		 4gkhG-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.12A 4gkhC-4oraA:
undetectable
4gkhK-4oraA:
undetectable		 4gkhC-4oraA:
20.30
4gkhK-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.13A 4gkiA-4oraA:
undetectable		 4gkiA-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.13A 4gkiA-4oraA:
undetectable		 4gkiA-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 0.96A 4gkiC-4oraA:
undetectable		 4gkiC-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 130
ASP A 127
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
FE  A 602 (-3.5A)
None
 1.03A 4gkiC-4oraA:
undetectable		 4gkiC-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 9 ASP A 130
ASP A 127
ARG A 163
GLU A 490
GLU A 161
 None
ZN  A 601 ( 3.7A)
None
FE  A 602 (-3.5A)
None
 1.48A 4gkiF-4oraA:
0.0		 4gkiF-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 127
ASN A 159
GLU A 490
GLU A 161
 ZN  A 601 ( 3.7A)
ZN  A 601 (-3.2A)
FE  A 602 (-3.5A)
None
 1.13A 4gkiE-4oraA:
undetectable
4gkiG-4oraA:
undetectable		 4gkiE-4oraA:
20.30
4gkiG-4oraA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ALA A 186
PHE A 191
ALA A  78
VAL A 129
CYH A 175
 None
 1.09A 4k6iA-4oraA:
undetectable		 4k6iA-4oraA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 ASN A 260
GLY A 209
GLY A 210
ASP A 238
GLY A  98
 None
 1.05A 4obwB-4oraA:
undetectable		 4obwB-4oraA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 149
TYR A 141
LEU A 142
PHE A 111
 None
 1.05A 4twdB-4oraA:
undetectable
4twdC-4oraA:
undetectable		 4twdB-4oraA:
18.93
4twdC-4oraA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 149
TYR A 141
LEU A 142
PHE A 111
 None
 1.00A 4twdD-4oraA:
undetectable
4twdE-4oraA:
undetectable		 4twdD-4oraA:
18.93
4twdE-4oraA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 TYR A 141
LEU A 142
PHE A 111
TYR A 149
 None
 1.13A 4twdF-4oraA:
undetectable
4twdJ-4oraA:
undetectable		 4twdF-4oraA:
18.93
4twdJ-4oraA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 149
TYR A 141
LEU A 142
PHE A 111
 None
 1.08A 4twdF-4oraA:
undetectable
4twdG-4oraA:
undetectable		 4twdF-4oraA:
18.93
4twdG-4oraA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 149
TYR A 141
LEU A 142
PHE A 111
 None
 1.13A 4twdI-4oraA:
undetectable
4twdJ-4oraA:
undetectable		 4twdI-4oraA:
18.93
4twdJ-4oraA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		6 / 6 LEU A 352
TRP A 361
SER A 362
PRO A 364
PHE A 365
GLU A 368
 None
 0.72A 5b8iA-4oraA:
55.7		 5b8iA-4oraA:
52.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 4 ASP A 127
HIS A 208
HIS A 290
HIS A 160
 ZN  A 601 ( 3.7A)
None
ZN  A 601 ( 3.5A)
None
 1.47A 5ncdD-4oraA:
undetectable		 5ncdD-4oraA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		5 / 12 LEU A 145
LEU A 107
PHE A 124
THR A  95
VAL A 330
 None
 1.23A 6debB-4oraA:
undetectable		 6debB-4oraA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 142
THR A 152
PRO A  50
ARG A  51
 None
 1.38A 6ew0B-4oraA:
undetectable		 6ew0B-4oraA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 142
THR A 152
PRO A  50
ARG A  51
 None
 1.38A 6ew0D-4oraA:
undetectable		 6ew0D-4oraA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 142
THR A 152
PRO A  50
ARG A  51
 None
 1.38A 6ew0H-4oraA:
undetectable		 6ew0H-4oraA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 142
THR A 152
PRO A  50
ARG A  51
 None
 1.38A 6ew0I-4oraA:
undetectable		 6ew0I-4oraA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens) 		4 / 7 ARG A 163
HIS A 164
ASP A 192
GLU A 189
 None
 1.31A 6mn4F-4oraA:
undetectable		 6mn4F-4oraA:
19.63