SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4orb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OE1_A_CUA502_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ASP A 118 HIS A 151 HIS A 92	ZN A 601 ( 3.0A) None FE A 602 (-4.1A)	0.66A	1oe1A-4orbA: undetectable	1oe1A-4orbA: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OE3_A_CUA502_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ASP A 118 HIS A 151 HIS A 92	ZN A 601 ( 3.0A) None FE A 602 (-4.1A)	0.64A	1oe3A-4orbA: undetectable	1oe3A-4orbA: 20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TCO_C_FK5C509_1 (SERINE/THREONINE PHOSPHATASE B2 FK506-BINDING PROTEIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 4	TRP A 352 SER A 353 PHE A 356 GLU A 359	None	0.41A	1tcoA-4orbA: 56.8	1tcoA-4orbA: 99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XP0_A_VDNA201_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 10	LEU A 139 ALA A 135 ILE A 138 VAL A 34 ALA A 31	None	1.10A	1xp0A-4orbA: undetectable	1xp0A-4orbA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3C_A_PNXA1435_1 (CHITINASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 291 GLY A 89 PHE A 306 SER A 307	None	1.38A	2a3cA-4orbA: undetectable	2a3cA-4orbA: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3C_B_PNXB2434_1 (CHITINASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 291 GLY A 89 PHE A 306 SER A 307	None	1.40A	2a3cB-4orbA: undetectable	2a3cB-4orbA: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	LEU A 139 ALA A 135 ILE A 138 VAL A 34 ALA A 31	None	1.07A	2h42C-4orbA: undetectable	2h42C-4orbA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2O_B_DHIB24_0 (INSULIN B CHAIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	ARG A 292 GLY A 240 LYS A 243 THR A 244	None	1.36A	2m2oB-4orbA: undetectable	2m2oB-4orbA: 6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OTH_A_IMNA301_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ASP A 90 TYR A 311 LYS A 464	FE A 602 ( 3.4A) None None	1.08A	2othA-4orbA: undetectable	2othA-4orbA: 11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XXG_A_CUA1338_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ASP A 118 HIS A 151 HIS A 92	ZN A 601 ( 3.0A) None FE A 602 (-4.1A)	0.68A	2xxgA-4orbA: undetectable	2xxgA-4orbA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XXG_C_CUC1339_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ASP A 118 HIS A 151 HIS A 92	ZN A 601 ( 3.0A) None FE A 602 (-4.1A)	0.69A	2xxgC-4orbA: undetectable	2xxgC-4orbA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_H_PZIH800_0 (GLUTAMATE RECEPTOR 2)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 8	TYR A 132 SER A 107 ASP A 44 LYS A 47	None	1.06A	3lsfH-4orbA: undetectable	3lsfH-4orbA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P6G_A_IZPA133_1 (FATTY ACID-BINDING PROTEIN, ADIPOCYTE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	PHE A 162 ILE A 65 VAL A 174 CYH A 178 TYR A 170	None	1.33A	3p6gA-4orbA: undetectable	3p6gA-4orbA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SDR_A_210A822_1 (ALPHA-BISABOLENE SYNTHASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 4	ASP A 90 ASP A 118 ARG A 279 ASP A 234	FE A 602 ( 3.4A) ZN A 601 ( 3.0A) None None	1.38A	3sdrA-4orbA: 0.0	3sdrA-4orbA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_C_C2FC1410_0 (GLYCINE N-METHYLTRANSFERASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	3 / 3	ARG A 73 PRO A 186 PHE A 218	None	0.89A	3thrC-4orbA: undetectable	3thrC-4orbA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_A_ADNA401_1 (ADENOSINE KINASE, PUTATIVE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ASP A 90 LEU A 302 ASN A 150 THR A 304 GLY A 149	FE A 602 ( 3.4A) None ZN A 601 (-2.7A) None None	1.04A	3uq6A-4orbA: undetectable	3uq6A-4orbA: 22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_B_ADNB401_1 (ADENOSINE KINASE, PUTATIVE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ASP A 90 LEU A 302 ASN A 150 THR A 304 GLY A 149	FE A 602 ( 3.4A) None ZN A 601 (-2.7A) None None	1.04A	3uq6B-4orbA: undetectable	3uq6B-4orbA: 22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_A_ADNA401_1 (PUTATIVE ADENOSINE KINASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ASP A 90 LEU A 302 ASN A 150 THR A 304 GLY A 149	FE A 602 ( 3.4A) None ZN A 601 (-2.7A) None None	1.02A	3vaqA-4orbA: undetectable	3vaqA-4orbA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_B_ADNB401_1 (PUTATIVE ADENOSINE KINASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ASP A 90 LEU A 302 ASN A 150 THR A 304 GLY A 149	FE A 602 ( 3.4A) None ZN A 601 (-2.7A) None None	1.06A	3vaqB-4orbA: undetectable	3vaqB-4orbA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAS_A_ADNA401_1 (PUTATIVE ADENOSINE KINASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ASP A 90 LEU A 302 ASN A 150 THR A 304 GLY A 149	FE A 602 ( 3.4A) None ZN A 601 (-2.7A) None None	1.01A	3vasA-4orbA: undetectable	3vasA-4orbA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	CYH A 88 SER A 307 HIS A 92 LEU A 98 LEU A 144	None None FE A 602 (-4.1A) None None	1.29A	3vn2A-4orbA: undetectable	3vn2A-4orbA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H2G_A_ADNA603_1 (5'-NUCLEOTIDASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 9	ARG A 472 ASN A 251 ARG A 468 GLY A 255 PHE A 259	None	1.44A	4h2gA-4orbA: 2.3	4h2gA-4orbA: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	ALA A 177 PHE A 182 ALA A 69 VAL A 120 CYH A 166	None	1.14A	4k6iA-4orbA: undetectable	4k6iA-4orbA: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KUK_A_RBFA201_2 (BLUE-LIGHT PHOTORECEPTOR)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 9	MET A 191 ILE A 305 ARG A 279 LEU A 116 ILE A 331	None	0.85A	4kukA-4orbA: undetectable	4kukA-4orbA: 15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_C_377C401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 140 TYR A 132 LEU A 133 PHE A 102	None	1.06A	4twdB-4orbA: undetectable 4twdC-4orbA: undetectable	4twdB-4orbA: 20.46 4twdC-4orbA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_E_377E401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 140 TYR A 132 LEU A 133 PHE A 102	None	1.03A	4twdD-4orbA: undetectable 4twdE-4orbA: undetectable	4twdD-4orbA: 20.46 4twdE-4orbA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_F_377F401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 7	TYR A 132 LEU A 133 PHE A 102 TYR A 140	None	1.13A	4twdF-4orbA: undetectable 4twdJ-4orbA: undetectable	4twdF-4orbA: 20.46 4twdJ-4orbA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_G_377G401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 140 TYR A 132 LEU A 133 PHE A 102	None	1.10A	4twdF-4orbA: undetectable 4twdG-4orbA: undetectable	4twdF-4orbA: 20.46 4twdG-4orbA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_J_377J401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	TYR A 140 TYR A 132 LEU A 133 PHE A 102	None	1.17A	4twdI-4orbA: undetectable 4twdJ-4orbA: undetectable	4twdI-4orbA: 20.46 4twdJ-4orbA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0S_A_PX9A201_0 (BETA-LACTOGLOBULIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	6 / 12	LEU A 209 LEU A 78 ILE A 212 ILE A 230 VAL A 198 LEU A 274	None	1.35A	4y0sA-4orbA: undetectable	4y0sA-4orbA: 14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B8I_C_FK5C201_1 (SERINE/THREONINE-PRO TEIN PHOSPHATASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	6 / 6	LEU A 343 TRP A 352 SER A 353 PRO A 355 PHE A 356 GLU A 359	None	0.64A	5b8iA-4orbA: 55.9	5b8iA-4orbA: 69.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NCD_C_ACTC301_0 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	ASP A 118 ASP A 90 HIS A 92 HIS A 199	ZN A 601 ( 3.0A) FE A 602 ( 3.4A) FE A 602 (-4.1A) ZN A 601 (-3.5A)	0.91A	5ncdB-4orbA: 2.5 5ncdC-4orbA: 2.4	5ncdB-4orbA: 18.13 5ncdC-4orbA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NCD_D_ACTD301_0 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 4	ASP A 118 HIS A 199 HIS A 281 HIS A 151	ZN A 601 ( 3.0A) ZN A 601 (-3.5A) ZN A 601 (-3.6A) None	1.45A	5ncdD-4orbA: undetectable	5ncdD-4orbA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NEL_A_ACTA302_0 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 6	ASP A 118 ASP A 90 HIS A 92 HIS A 199	ZN A 601 ( 3.0A) FE A 602 ( 3.4A) FE A 602 (-4.1A) ZN A 601 (-3.5A)	0.92A	5nelA-4orbA: 2.4 5nelD-4orbA: 2.4	5nelA-4orbA: 18.13 5nelD-4orbA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	5 / 12	LEU A 136 LEU A 98 PHE A 115 THR A 86 VAL A 321	None	1.23A	6debB-4orbA: undetectable	6debB-4orbA: 11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 5	LEU A 133 THR A 143 PRO A 41 ARG A 42	None	1.41A	6ew0B-4orbA: undetectable	6ew0B-4orbA: 11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 5	LEU A 133 THR A 143 PRO A 41 ARG A 42	None	1.41A	6ew0D-4orbA: undetectable	6ew0D-4orbA: 11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 5	LEU A 133 THR A 143 PRO A 41 ARG A 42	None	1.41A	6ew0H-4orbA: undetectable	6ew0H-4orbA: 11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	4orb	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Mus musculus)	4 / 5	LEU A 133 THR A 143 PRO A 41 ARG A 42	None	1.41A	6ew0I-4orbA: undetectable	6ew0I-4orbA: 11.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1OE1_A_CUA502_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ASP A 118;HIS A 151;HIS A  92"," ZN A 601 ( 3.0A);None; FE A 602 (-4.1A)","0.66A","1oe1A-4orbA:undetectable","1oe1A-4orbA:20.68"],["1OE3_A_CUA502_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ASP A 118;HIS A 151;HIS A  92"," ZN A 601 ( 3.0A);None; FE A 602 (-4.1A)","0.64A","1oe3A-4orbA:undetectable","1oe3A-4orbA:20.68"],["1TCO_C_FK5C509_1","SERINE\/THREONINE PHOSPHATASE B2;FK506-BINDING PROTEIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TRP A 352;SER A 353;PHE A 356;GLU A 359","None","0.41A","1tcoA-4orbA:56.8","1tcoA-4orbA:99.47"],["1XP0_A_VDNA201_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"LEU A 139;ALA A 135;ILE A 138;VAL A  34;ALA A  31","None","1.10A","1xp0A-4orbA:undetectable","1xp0A-4orbA:22.88"],["2A3C_A_PNXA1435_1","CHITINASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 291;GLY A  89;PHE A 306;SER A 307","None","1.38A","2a3cA-4orbA:undetectable","2a3cA-4orbA:20.42"],["2A3C_B_PNXB2434_1","CHITINASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 291;GLY A  89;PHE A 306;SER A 307","None","1.40A","2a3cB-4orbA:undetectable","2a3cB-4orbA:20.42"],["2H42_C_VIAC903_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"LEU A 139;ALA A 135;ILE A 138;VAL A  34;ALA A  31","None","1.07A","2h42C-4orbA:undetectable","2h42C-4orbA:22.48"],["2M2O_B_DHIB24_0","INSULIN B CHAIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"ARG A 292;GLY A 240;LYS A 243;THR A 244","None","1.36A","2m2oB-4orbA:undetectable","2m2oB-4orbA:6.11"],["2OTH_A_IMNA301_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ASP A  90;TYR A 311;LYS A 464"," FE A 602 ( 3.4A);None;None","1.08A","2othA-4orbA:undetectable","2othA-4orbA:11.39"],["2XXG_A_CUA1338_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ASP A 118;HIS A 151;HIS A  92"," ZN A 601 ( 3.0A);None; FE A 602 (-4.1A)","0.68A","2xxgA-4orbA:undetectable","2xxgA-4orbA:20.87"],["2XXG_C_CUC1339_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ASP A 118;HIS A 151;HIS A  92"," ZN A 601 ( 3.0A);None; FE A 602 (-4.1A)","0.69A","2xxgC-4orbA:undetectable","2xxgC-4orbA:20.87"],["3LSF_H_PZIH800_0","GLUTAMATE RECEPTOR 2","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 132;SER A 107;ASP A  44;LYS A  47","None","1.06A","3lsfH-4orbA:undetectable","3lsfH-4orbA:19.69"],["3P6G_A_IZPA133_1","FATTY ACID-BINDING PROTEIN, ADIPOCYTE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"PHE A 162;ILE A  65;VAL A 174;CYH A 178;TYR A 170","None","1.33A","3p6gA-4orbA:undetectable","3p6gA-4orbA:15.38"],["3SDR_A_210A822_1","ALPHA-BISABOLENE SYNTHASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"ASP A  90;ASP A 118;ARG A 279;ASP A 234"," FE A 602 ( 3.4A); ZN A 601 ( 3.0A);None;None","1.38A","3sdrA-4orbA:0.0","3sdrA-4orbA:23.64"],["3THR_C_C2FC1410_0","GLYCINE N-METHYLTRANSFERASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",3,"ARG A  73;PRO A 186;PHE A 218","None","0.89A","3thrC-4orbA:undetectable","3thrC-4orbA:22.07"],["3UQ6_A_ADNA401_1","ADENOSINE KINASE, PUTATIVE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ASP A  90;LEU A 302;ASN A 150;THR A 304;GLY A 149"," FE A 602 ( 3.4A);None; ZN A 601 (-2.7A);None;None","1.04A","3uq6A-4orbA:undetectable","3uq6A-4orbA:22.24"],["3UQ6_B_ADNB401_1","ADENOSINE KINASE, PUTATIVE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ASP A  90;LEU A 302;ASN A 150;THR A 304;GLY A 149"," FE A 602 ( 3.4A);None; ZN A 601 (-2.7A);None;None","1.04A","3uq6B-4orbA:undetectable","3uq6B-4orbA:22.24"],["3VAQ_A_ADNA401_1","PUTATIVE ADENOSINE KINASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ASP A  90;LEU A 302;ASN A 150;THR A 304;GLY A 149"," FE A 602 ( 3.4A);None; ZN A 601 (-2.7A);None;None","1.02A","3vaqA-4orbA:undetectable","3vaqA-4orbA:22.39"],["3VAQ_B_ADNB401_1","PUTATIVE ADENOSINE KINASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ASP A  90;LEU A 302;ASN A 150;THR A 304;GLY A 149"," FE A 602 ( 3.4A);None; ZN A 601 (-2.7A);None;None","1.06A","3vaqB-4orbA:undetectable","3vaqB-4orbA:22.39"],["3VAS_A_ADNA401_1","PUTATIVE ADENOSINE KINASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ASP A  90;LEU A 302;ASN A 150;THR A 304;GLY A 149"," FE A 602 ( 3.4A);None; ZN A 601 (-2.7A);None;None","1.01A","3vasA-4orbA:undetectable","3vasA-4orbA:22.48"],["3VN2_A_TLSA501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"CYH A  88;SER A 307;HIS A  92;LEU A  98;LEU A 144","None;None; FE A 602 (-4.1A);None;None","1.29A","3vn2A-4orbA:undetectable","3vn2A-4orbA:20.20"],["4H2G_A_ADNA603_1","5'-NUCLEOTIDASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ARG A 472;ASN A 251;ARG A 468;GLY A 255;PHE A 259","None","1.44A","4h2gA-4orbA:2.3","4h2gA-4orbA:23.15"],["4K6I_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"ALA A 177;PHE A 182;ALA A  69;VAL A 120;CYH A 166","None","1.14A","4k6iA-4orbA:undetectable","4k6iA-4orbA:18.38"],["4KUK_A_RBFA201_2","BLUE-LIGHT PHOTORECEPTOR","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"MET A 191;ILE A 305;ARG A 279;LEU A 116;ILE A 331","None","0.85A","4kukA-4orbA:undetectable","4kukA-4orbA:15.41"],["4TWD_C_377C401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 140;TYR A 132;LEU A 133;PHE A 102","None","1.06A","4twdB-4orbA:undetectable;4twdC-4orbA:undetectable","4twdB-4orbA:20.46;4twdC-4orbA:20.46"],["4TWD_E_377E401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 140;TYR A 132;LEU A 133;PHE A 102","None","1.03A","4twdD-4orbA:undetectable;4twdE-4orbA:undetectable","4twdD-4orbA:20.46;4twdE-4orbA:20.46"],["4TWD_F_377F401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 132;LEU A 133;PHE A 102;TYR A 140","None","1.13A","4twdF-4orbA:undetectable;4twdJ-4orbA:undetectable","4twdF-4orbA:20.46;4twdJ-4orbA:20.46"],["4TWD_G_377G401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 140;TYR A 132;LEU A 133;PHE A 102","None","1.10A","4twdF-4orbA:undetectable;4twdG-4orbA:undetectable","4twdF-4orbA:20.46;4twdG-4orbA:20.46"],["4TWD_J_377J401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"TYR A 140;TYR A 132;LEU A 133;PHE A 102","None","1.17A","4twdI-4orbA:undetectable;4twdJ-4orbA:undetectable","4twdI-4orbA:20.46;4twdJ-4orbA:20.46"],["4Y0S_A_PX9A201_0","BETA-LACTOGLOBULIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",6,"LEU A 209;LEU A  78;ILE A 212;ILE A 230;VAL A 198;LEU A 274","None","1.35A","4y0sA-4orbA:undetectable","4y0sA-4orbA:14.94"],["5B8I_C_FK5C201_1","SERINE\/THREONINE-PROTEIN PHOSPHATASE;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",6,"LEU A 343;TRP A 352;SER A 353;PRO A 355;PHE A 356;GLU A 359","None","0.64A","5b8iA-4orbA:55.9","5b8iA-4orbA:69.04"],["5NCD_C_ACTC301_0","PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"ASP A 118;ASP A  90;HIS A  92;HIS A 199"," ZN A 601 ( 3.0A); FE A 602 ( 3.4A); FE A 602 (-4.1A); ZN A 601 (-3.5A)","0.91A","5ncdB-4orbA:2.5;5ncdC-4orbA:2.4","5ncdB-4orbA:18.13;5ncdC-4orbA:18.13"],["5NCD_D_ACTD301_0","PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"ASP A 118;HIS A 199;HIS A 281;HIS A 151"," ZN A 601 ( 3.0A); ZN A 601 (-3.5A); ZN A 601 (-3.6A);None","1.45A","5ncdD-4orbA:undetectable","5ncdD-4orbA:18.13"],["5NEL_A_ACTA302_0","PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"ASP A 118;ASP A  90;HIS A  92;HIS A 199"," ZN A 601 ( 3.0A); FE A 602 ( 3.4A); FE A 602 (-4.1A); ZN A 601 (-3.5A)","0.92A","5nelA-4orbA:2.4;5nelD-4orbA:2.4","5nelA-4orbA:18.13;5nelD-4orbA:18.13"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",5,"LEU A 136;LEU A  98;PHE A 115;THR A  86;VAL A 321","None","1.23A","6debB-4orbA:undetectable","6debB-4orbA:11.49"],["6EW0_B_TA1B501_2","TUBULIN BETA CHAIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"LEU A 133;THR A 143;PRO A  41;ARG A  42","None","1.41A","6ew0B-4orbA:undetectable","6ew0B-4orbA:11.48"],["6EW0_D_TA1D501_2","TUBULIN BETA CHAIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"LEU A 133;THR A 143;PRO A  41;ARG A  42","None","1.41A","6ew0D-4orbA:undetectable","6ew0D-4orbA:11.48"],["6EW0_H_TA1H501_2","TUBULIN BETA CHAIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"LEU A 133;THR A 143;PRO A  41;ARG A  42","None","1.41A","6ew0H-4orbA:undetectable","6ew0H-4orbA:11.48"],["6EW0_I_TA1I501_2","TUBULIN BETA CHAIN","4orb","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM","Mus musculus",4,"LEU A 133;THR A 143;PRO A  41;ARG A  42","None","1.41A","6ew0I-4orbA:undetectable","6ew0I-4orbA:11.48"]]