SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ord'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 10 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.10A 1c9sN-4ordA:
undetectable
1c9sO-4ordA:
undetectable		 1c9sN-4ordA:
22.97
1c9sO-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 11 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.10A 1c9sP-4ordA:
undetectable
1c9sQ-4ordA:
undetectable		 1c9sP-4ordA:
22.97
1c9sQ-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 9 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.12A 1c9sQ-4ordA:
undetectable
1c9sR-4ordA:
undetectable		 1c9sQ-4ordA:
22.97
1c9sR-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 10 GLY A  58
GLY A  54
HIS A  57
THR A  50
ILE A  97
 None
 1.10A 1c9sL-4ordA:
undetectable
1c9sV-4ordA:
undetectable		 1c9sL-4ordA:
22.97
1c9sV-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 9 GLY A  58
GLY A  54
HIS A  57
THR A  50
ILE A  97
 None
 1.09A 1gtfD-4ordA:
undetectable
1gtfE-4ordA:
undetectable		 1gtfD-4ordA:
22.97
1gtfE-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 11 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.12A 1gtfQ-4ordA:
undetectable
1gtfR-4ordA:
undetectable		 1gtfQ-4ordA:
22.97
1gtfR-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 9 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.12A 1gtfR-4ordA:
undetectable
1gtfS-4ordA:
undetectable		 1gtfR-4ordA:
22.97
1gtfS-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 11 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.11A 1gtfS-4ordA:
undetectable
1gtfT-4ordA:
undetectable		 1gtfS-4ordA:
22.97
1gtfT-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 11 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.12A 1gtnT-4ordA:
undetectable
1gtnU-4ordA:
undetectable		 1gtnT-4ordA:
22.97
1gtnU-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 10 GLY A  54
HIS A  57
THR A  50
ILE A  97
GLY A  58
 None
 1.13A 1utdU-4ordA:
undetectable
1utdV-4ordA:
undetectable		 1utdU-4ordA:
22.97
1utdV-4ordA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 12 LYS A  44
LEU A  64
ILE A  68
GLY A 133
LEU A 129
 None
 1.27A 2lbdA-4ordA:
undetectable		 2lbdA-4ordA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		3 / 3 HIS A  49
MET A  60
MET A  43
 None
 1.11A 2vj1A-4ordA:
undetectable		 2vj1A-4ordA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 12 ALA A 115
PRO A  81
GLY A  79
SER A  84
ARG A 134
 None
 1.31A 5zvgA-4ordA:
undetectable		 5zvgA-4ordA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4ord THIOESTERASE
SUPERFAMILY MEMBER 2
(Danio
rerio) 		5 / 12 ALA A 115
PRO A  81
GLY A  79
SER A  84
ARG A 134
 None
 1.31A 5zvgB-4ordA:
undetectable		 5zvgB-4ordA:
19.39