SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		5 / 12 GLU A 467
PHE A 448
SER A 407
LEU A 376
ILE A 400
 None
 1.15A 2xkwB-4oroA:
undetectable		 2xkwB-4oroA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.19A 3jx1A-4oroA:
undetectable
3jx1B-4oroA:
undetectable		 3jx1A-4oroA:
18.21
3jx1B-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.23A 3nlyA-4oroA:
undetectable
3nlyB-4oroA:
undetectable		 3nlyA-4oroA:
18.21
3nlyB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.15A 3rqlA-4oroA:
undetectable
3rqlB-4oroA:
undetectable		 3rqlA-4oroA:
18.21
3rqlB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.19A 4capA-4oroA:
undetectable
4capB-4oroA:
undetectable		 4capA-4oroA:
18.21
4capB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.10A 4cx7A-4oroA:
undetectable
4cx7B-4oroA:
undetectable		 4cx7A-4oroA:
17.79
4cx7B-4oroA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.18A 4d32A-4oroA:
undetectable
4d32B-4oroA:
undetectable		 4d32A-4oroA:
18.21
4d32B-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		3 / 3 THR A 482
ASN A 389
SER A 390
 None
 0.61A 4tvtA-4oroA:
undetectable		 4tvtA-4oroA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.16A 4v3yA-4oroA:
undetectable
4v3yB-4oroA:
undetectable		 4v3yA-4oroA:
18.21
4v3yB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 7 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.25A 5adlA-4oroA:
undetectable
5adlB-4oroA:
undetectable		 5adlA-4oroA:
18.69
5adlB-4oroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		3 / 3 MET A 412
GLN A 414
ARG A 417
 None
 1.11A 5ewzB-4oroA:
undetectable		 5ewzB-4oroA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 7 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.25A 5fj3A-4oroA:
undetectable
5fj3B-4oroA:
undetectable		 5fj3A-4oroA:
18.69
5fj3B-4oroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 5 PHE A 406
SER A 407
GLN A 437
ASP A 395
 GDP  A 501 (-4.2A)
None
None
None
 1.42A 5kpcA-4oroA:
undetectable		 5kpcA-4oroA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.25A 5uo7A-4oroA:
undetectable
5uo7B-4oroA:
undetectable		 5uo7A-4oroA:
18.51
5uo7B-4oroA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 6 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.22A 5uo8A-4oroA:
undetectable
5uo8B-4oroA:
undetectable		 5uo8A-4oroA:
19.89
5uo8B-4oroA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		3 / 3 ARG A 368
GLY A 370
GLU A 371
 None
 0.52A 6fgdA-4oroA:
undetectable		 6fgdA-4oroA:
16.51