SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4orx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_A_9CRA165_1 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	4orx	PROSTAGLANDIN-H2 D-ISOMERASE (Homo sapiens)	5 / 12	PHE A 34 TRP A 43 VAL A 69 VAL A 120 ALA A 129	None	0.59A	1epbA-4orxA: 19.0	1epbA-4orxA: 24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_X_BRLX504_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	4orx	PROSTAGLANDIN-H2 D-ISOMERASE (Homo sapiens)	5 / 12	PHE A 39 GLY A 41 SER A 67 LEU A 131 LEU A 79	None	0.95A	1fm6X-4orxA: undetectable	1fm6X-4orxA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK3_A_T44A3003_1 (SERUM ALBUMIN)	4orx	PROSTAGLANDIN-H2 D-ISOMERASE (Homo sapiens)	3 / 4	LYS A 66 ALA A 65 MET A 187	None	0.87A	1hk3A-4orxA: undetectable	1hk3A-4orxA: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4orx	PROSTAGLANDIN-H2 D-ISOMERASE (Homo sapiens)	4 / 6	PHE A 39 VAL A 69 LEU A 79 PHE A 34	None	0.97A	1wrlB-4orxA: undetectable	1wrlB-4orxA: 16.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EPB_A_9CRA165_1","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","4orx","PROSTAGLANDIN-H2 D-ISOMERASE","Homo sapiens",5,"PHE A  34;TRP A  43;VAL A  69;VAL A 120;ALA A 129","None","0.59A","1epbA-4orxA:19.0","1epbA-4orxA:24.50"],["1FM6_X_BRLX504_1","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","4orx","PROSTAGLANDIN-H2 D-ISOMERASE","Homo sapiens",5,"PHE A  39;GLY A  41;SER A  67;LEU A 131;LEU A  79","None","0.95A","1fm6X-4orxA:undetectable","1fm6X-4orxA:22.11"],["1HK3_A_T44A3003_1","SERUM ALBUMIN","4orx","PROSTAGLANDIN-H2 D-ISOMERASE","Homo sapiens",3,"LYS A  66;ALA A  65;MET A 187","None","0.87A","1hk3A-4orxA:undetectable","1hk3A-4orxA:15.52"],["1WRL_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4orx","PROSTAGLANDIN-H2 D-ISOMERASE","Homo sapiens",4,"PHE A  39;VAL A  69;LEU A  79;PHE A  34","None","0.97A","1wrlB-4orxA:undetectable","1wrlB-4orxA:16.84"]]