SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 224
GLY A  13
None
None
NAP  A 301 (-3.6A)
None
NAP  A 301 (-3.2A)
0.88A 2qe6A-4osoA:
5.8
2qe6A-4osoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
4 / 5 SER A 147
ILE A  18
TYR A 160
GLY A 191
2V4  A 302 (-2.5A)
NAP  A 301 (-3.6A)
2V4  A 302 ( 4.4A)
2V4  A 302 ( 3.5A)
0.96A 3uboB-4osoA:
6.8
3uboB-4osoA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 12 LEU A  78
GLY A   6
ALA A  31
LEU A  91
GLY A  56
None
1.00A 4dc3A-4osoA:
7.4
4dc3A-4osoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 12 LEU A  91
ILE A 142
ALA A  23
ALA A  34
VAL A  33
None
1.11A 4hfpD-4osoA:
undetectable
4hfpD-4osoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 12 ALA A 232
PHE A  75
LYS A   7
LEU A  82
PHE A  59
None
1.24A 4kykA-4osoA:
undetectable
4kykB-4osoA:
undetectable
4kykA-4osoA:
20.97
4kykB-4osoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
4 / 4 LEU A  32
LEU A  82
GLY A  81
GLU A  84
None
1.25A 5hhjA-4osoA:
undetectable
5hhjA-4osoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 12 SER A 134
THR A  86
LEU A  94
PHE A  59
LEU A  74
None
1.40A 6a93A-4osoA:
undetectable
6a93A-4osoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)
4oso REDUCTASE HOMOLOG
(Streptomyces
cyanogenus)
5 / 10 VAL A  95
LEU A  94
LEU A   4
GLY A  13
GLY A  27
None
None
None
NAP  A 301 (-3.2A)
None
1.16A 6eu9B-4osoA:
undetectable
6eu9B-4osoA:
14.50