SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4osp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		5 / 12 LEU A  26
LEU A   4
GLY A  30
THR A  47
ILE A  24
 None
 1.45A 1p93A-4ospA:
undetectable		 1p93A-4ospA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		4 / 7 SER A  15
SER A  38
GLU A  64
ASP A  70
 NAP  A 301 (-2.7A)
NAP  A 301 (-4.4A)
NAP  A 301 (-4.0A)
None
 1.26A 3bc9A-4ospA:
undetectable		 3bc9A-4ospA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		4 / 5 ASN A 154
LEU A 113
GLY A 102
THR A 197
 None
 0.91A 3dl9A-4ospA:
undetectable		 3dl9A-4ospA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		5 / 9 VAL A 129
ILE A 142
ILE A 145
ALA A 124
ILE A 128
 None
None
NAP  A 301 (-4.5A)
None
None
 1.02A 3el0B-4ospA:
undetectable		 3el0B-4ospA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		4 / 5 ASN A 182
ARG A 141
ASN A 186
ALA A 175
 None
 1.40A 3frqA-4ospA:
undetectable		 3frqA-4ospA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		4 / 5 SER A 147
ILE A  18
TYR A 160
GLY A 191
 2V4  A 302 ( 3.0A)
NAP  A 301 (-3.9A)
NAP  A 301 ( 4.3A)
2V4  A 302 (-3.8A)
 0.98A 3uboB-4ospA:
6.9		 3uboB-4ospA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		5 / 12 LEU A  94
GLY A 233
ASP A 234
ARG A 237
LEU A  91
 None
 1.10A 5h5fA-4ospA:
2.6		 5h5fA-4ospA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		5 / 12 SER A 213
VAL A 218
ALA A 207
ALA A 210
GLY A 211
 None
 1.32A 5tzoA-4ospA:
undetectable		 5tzoA-4ospA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4osp OXYGENASE-REDUCTASE
(Streptomyces
fradiae) 		5 / 12 SER A 213
VAL A 218
ALA A 207
ALA A 210
GLY A 211
 None
 1.33A 5tzoC-4ospA:
undetectable		 5tzoC-4ospA:
21.97