SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ot9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 4 THR A 684
LEU A 687
VAL A 650
LEU A 653
 None
 0.87A 1fbmD-4ot9A:
undetectable		 1fbmD-4ot9A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 4 THR A 684
LEU A 687
VAL A 650
LEU A 653
 None
 0.93A 1mz9D-4ot9A:
undetectable		 1mz9D-4ot9A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 682
THR A 684
PRO A 681
 None
 0.85A 1unjW-4ot9A:
undetectable		 1unjW-4ot9A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 684
PRO A 681
THR A 682
 None
 0.87A 1unmE-4ot9A:
undetectable		 1unmE-4ot9A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 682
THR A 684
PRO A 681
 None
 0.84A 1unmE-4ot9A:
undetectable		 1unmE-4ot9A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 8 ALA A 637
ALA A 659
LEU A 619
VAL A 620
 None
 0.87A 2bxgA-4ot9A:
2.4		 2bxgA-4ot9A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 7 PRO A 553
ALA A 588
LEU A 547
ALA A 580
 None
 1.17A 2vcvA-4ot9A:
undetectable		 2vcvA-4ot9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 674
VAL A 620
VAL A 608
MET A 644
 SO4  A 802 ( 4.9A)
None
None
None
 1.12A 3k5vA-4ot9A:
undetectable		 3k5vA-4ot9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 546
SER A 544
PHE A 545
ILE A 504
 None
 1.00A 3ko0B-4ot9A:
undetectable		 3ko0B-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 546
SER A 544
PHE A 545
ILE A 504
 None
 0.98A 3ko0S-4ot9A:
undetectable		 3ko0S-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		5 / 12 HIS A 493
LEU A 555
GLY A 550
ALA A 551
LEU A 547
 None
 1.20A 3n8xA-4ot9A:
undetectable		 3n8xA-4ot9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 8 ARG A 658
ALA A 624
LEU A 592
ASP A 617
 None
 0.88A 3qj7A-4ot9A:
undetectable
3qj7D-4ot9A:
undetectable		 3qj7A-4ot9A:
23.08
3qj7D-4ot9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 568
HIS A 565
MET A 564
 None
 0.94A 3thrD-4ot9A:
undetectable		 3thrD-4ot9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA A 580
ALA A 588
PRO A 587
LEU A 547
 None
 1.09A 4dtzB-4ot9A:
undetectable		 4dtzB-4ot9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 PHE A 451
SER A 457
LEU A 453
LEU A 450
 None
 1.18A 5dzke-4ot9A:
2.7
5dzks-4ot9A:
undetectable		 5dzke-4ot9A:
20.95
5dzks-4ot9A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		5 / 9 THR A 482
LEU A 481
ILE A 511
PRO A 530
LEU A 492
 None
 1.23A 5g48B-4ot9A:
undetectable		 5g48B-4ot9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 546
ALA A 551
THR A 490
ASN A 524
 None
 1.01A 6f88A-4ot9A:
undetectable		 6f88A-4ot9A:
14.97