SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4otd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 LEU A 788
VAL A 792
THR A 778
VAL A 743
ASP A 803
 None
None
TPO  A 780 ( 2.6A)
None
None
 1.46A 1dz8B-4otdA:
undetectable		 1dz8B-4otdA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
LEU A 753
ASP A 764
PHE A 910
 None
 0.59A 1fmoE-4otdA:
39.6		 1fmoE-4otdA:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
GLY A 628
VAL A 635
ALA A 648
TYR A 703
LEU A 753
 None
 0.73A 1muoA-4otdA:
9.3		 1muoA-4otdA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 LEU A 627
VAL A 635
ALA A 648
GLY A 707
LEU A 753
 None
 0.51A 1xbbA-4otdA:
24.4		 1xbbA-4otdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 12 LEU A 652
LEU A 666
GLY A 766
ASP A 764
ASP A 750
 None
 1.03A 2bm9B-4otdA:
undetectable		 2bm9B-4otdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 VAL A 635
LYS A 650
VAL A 685
ASP A 708
ASN A 751
LEU A 753
ALA A 763
ASP A 764
 None
 0.85A 2eufB-4otdA:
26.5		 2eufB-4otdA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		3 / 3 PHE A 691
PHE A 621
PHE A 623
 None
 0.81A 2od9A-4otdA:
undetectable		 2od9A-4otdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		3 / 3 PHE A 691
PHE A 621
PHE A 623
 None
 0.81A 2qqgA-4otdA:
undetectable		 2qqgA-4otdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 12 LEU A 627
GLY A 628
ALA A 648
VAL A 685
GLY A 707
LEU A 753
 None
 0.59A 3c7qA-4otdA:
20.9		 3c7qA-4otdA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
GLY A 628
GLY A 630
VAL A 635
ALA A 648
TYR A 703
LEU A 753
 None
 0.48A 3fupB-4otdA:
24.7		 3fupB-4otdA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 11 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.50A 3g0eA-4otdA:
15.7		 3g0eA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 11 LEU A 627
VAL A 635
ALA A 648
TYR A 703
GLY A 707
ASP A 708
LEU A 753
 None
 0.57A 3g0fA-4otdA:
21.9		 3g0fA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
ALA A 648
TYR A 703
GLY A 707
LEU A 753
 None
 0.32A 3g0fB-4otdA:
22.2		 3g0fB-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.55A 3g5dA-4otdA:
22.8		 3g5dA-4otdA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
ALA A 763
 None
 0.88A 3lxkA-4otdA:
24.6		 3lxkA-4otdA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
LEU A 753
ALA A 763
ASP A 764
 None
 1.08A 3lxkA-4otdA:
24.6		 3lxkA-4otdA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.55A 3octA-4otdA:
22.0		 3octA-4otdA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.78A 3qlgA-4otdA:
22.1		 3qlgA-4otdA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ALA A 763
 None
 0.70A 3qlgB-4otdA:
22.6		 3qlgB-4otdA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.57A 3sxrA-4otdA:
25.1		 3sxrA-4otdA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.57A 3sxrB-4otdA:
24.7		 3sxrB-4otdA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 ALA A 648
VAL A 685
ASP A 708
LEU A 753
ASP A 764
 None
 0.80A 3ti1A-4otdA:
23.4		 3ti1A-4otdA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 12 GLY A 773
GLY A 771
ARG A 745
ASP A 803
TRP A 804
 None
None
TPO  A 780 ( 2.8A)
None
None
 1.09A 4a6eA-4otdA:
undetectable		 4a6eA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 12 LEU A 627
VAL A 635
ALA A 648
LEU A 673
GLY A 707
LEU A 753
 None
 0.53A 4agcA-4otdA:
21.2		 4agcA-4otdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 11 LEU A 627
ALA A 648
VAL A 685
GLY A 707
LEU A 753
 None
 0.47A 4agdA-4otdA:
20.9		 4agdA-4otdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 9 LEU A 627
VAL A 635
ALA A 648
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 1.08A 4anqA-4otdA:
22.0		 4anqA-4otdA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 9 LEU A 627
VAL A 635
ALA A 648
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 1.13A 4ansA-4otdA:
21.9		 4ansA-4otdA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 10 LEU A 627
GLY A 628
GLY A 630
VAL A 635
ALA A 648
TYR A 703
LEU A 753
 None
 0.43A 4ckjA-4otdA:
25.3		 4ckjA-4otdA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 648
ILE A 672
VAL A 685
TYR A 703
LEU A 753
ALA A 763
 None
 1.00A 4csvA-4otdA:
22.7		 4csvA-4otdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 VAL A 635
ALA A 648
ASP A 708
ASP A 746
LYS A 748
ASN A 751
LEU A 753
ASP A 764
 None
 0.79A 4i41A-4otdA:
29.1		 4i41A-4otdA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 11 VAL A 635
ALA A 648
LYS A 650
ASP A 708
LEU A 753
ASP A 764
 None
 1.02A 4iaaA-4otdA:
28.7		 4iaaA-4otdA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		3 / 3 LYS A 634
LEU A 636
ALA A 651
 SEP  A 922 ( 2.8A)
None
None
 0.56A 4iizA-4otdA:
undetectable		 4iizA-4otdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.81A 4mxxB-4otdA:
21.6		 4mxxB-4otdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
MET A 701
TYR A 703
GLY A 707
ASP A 764
 None
 0.89A 4mxyA-4otdA:
23.3		 4mxyA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ASP A 764
 None
 0.94A 4mxyA-4otdA:
23.3		 4mxyA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.98A 4mxyB-4otdA:
23.1		 4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ASP A 764
 None
 0.95A 4mxyB-4otdA:
23.1		 4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 0.99A 4mxyB-4otdA:
23.1		 4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
MET A 701
TYR A 703
GLY A 707
ASP A 764
 None
 0.89A 4mxzA-4otdA:
23.3		 4mxzA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ASP A 764
 None
 0.94A 4mxzA-4otdA:
23.3		 4mxzA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
 None
 0.98A 4mxzB-4otdA:
23.1		 4mxzB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ASP A 764
 None
 0.95A 4mxzB-4otdA:
23.1		 4mxzB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 0.99A 4mxzB-4otdA:
23.1		 4mxzB-4otdA:
26.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 6 LEU A 627
GLY A 628
VAL A 635
ALA A 648
LEU A 753
 None
 0.35A 4o0wA-4otdA:
30.6		 4o0wA-4otdA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 648
ASP A 708
ASN A 751
LEU A 753
ASP A 764
 None
 0.77A 4ogrI-4otdA:
26.2		 4ogrI-4otdA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		9 / 12 LEU A 627
GLY A 628
GLY A 630
GLY A 633
VAL A 635
ALA A 648
LYS A 650
LEU A 753
PHE A 910
 None
 0.72A 4otiA-4otdA:
44.6		 4otiA-4otdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		10 / 12 LEU A 627
GLY A 628
GLY A 633
VAL A 635
ALA A 648
LYS A 650
VAL A 685
LEU A 753
ALA A 763
PHE A 910
 None
 0.45A 4otiA-4otdA:
44.6		 4otiA-4otdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 0.84A 4otwA-4otdA:
16.8		 4otwA-4otdA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 11 ALA A 648
GLU A 669
MET A 701
TYR A 703
LEU A 753
ASP A 764
 None
 0.86A 4qmsA-4otdA:
29.5		 4qmsA-4otdA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 12 GLY A 628
VAL A 635
ALA A 648
MET A 701
TYR A 703
LEU A 753
 None
 0.69A 4qmzA-4otdA:
29.1		 4qmzA-4otdA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 5 LEU A 627
VAL A 685
TYR A 703
ARG A 745
 None
None
None
TPO  A 780 ( 2.8A)
 0.83A 4r7iA-4otdA:
21.6		 4r7iA-4otdA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
VAL A 635
ALA A 648
GLY A 707
ASN A 751
LEU A 753
ALA A 763
ASP A 764
 None
 0.91A 4twpB-4otdA:
24.4		 4twpB-4otdA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		10 / 11 LEU A 627
GLY A 630
VAL A 635
ALA A 648
TYR A 703
GLY A 707
ASN A 751
LEU A 753
ALA A 763
ASP A 764
 None
 0.89A 4u5jA-4otdA:
24.3		 4u5jA-4otdA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
ALA A 648
TYR A 703
GLY A 707
LEU A 753
 None
 0.50A 4u5jB-4otdA:
23.7		 4u5jB-4otdA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 0.96A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.69A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 1.02A 4v01B-4otdA:
21.6		 4v01B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 1.11A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.90A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 10 GLY A 808
LEU A 815
ALA A 723
SER A 727
ALA A 728
 None
 0.64A 4wnuD-4otdA:
undetectable		 4wnuD-4otdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		8 / 12 LEU A 627
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ALA A 763
 None
 0.84A 4xliB-4otdA:
24.7		 4xliB-4otdA:
27.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 12 LEU A 627
ALA A 648
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 0.63A 5ajqA-4otdA:
24.7		 5ajqA-4otdA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 10 ALA A 723
GLU A 720
LEU A 815
GLY A 808
LEU A 810
 None
 1.40A 5dxbA-4otdA:
undetectable		 5dxbA-4otdA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 7 GLY A 628
GLY A 630
GLY A 633
VAL A 635
LEU A 652
 None
 0.78A 5izjB-4otdA:
36.5		 5izjB-4otdA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 7 GLY A 628
GLY A 630
VAL A 635
LEU A 652
 None
 0.42A 5izjA-4otdA:
38.1		 5izjA-4otdA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 7 GLY A 628
GLY A 630
VAL A 635
LYS A 650
ASP A 764
 None
 0.64A 5j5xA-4otdA:
39.6		 5j5xA-4otdA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 6 GLU A 818
PRO A 841
GLY A 817
PHE A 843
 None
 1.39A 5jcnB-4otdA:
undetectable		 5jcnB-4otdA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 GLY A 628
VAL A 635
ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
 None
 0.64A 5l2iA-4otdA:
7.3		 5l2iA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
ASP A 764
 None
 0.89A 5l2iA-4otdA:
7.3		 5l2iA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 12 ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
ASP A 764
 None
 0.93A 5l2tA-4otdA:
7.3		 5l2tA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 11 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
 None
 0.38A 5lvnA-4otdA:
27.6		 5lvnA-4otdA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
 None
 0.79A 5n3hA-4otdA:
39.8		 5n3hA-4otdA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 10 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
PHE A 910
 None
 0.68A 5n3hA-4otdA:
39.8		 5n3hA-4otdA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 4 VAL A 635
LYS A 650
VAL A 685
ASN A 751
 None
 0.93A 5vc3A-4otdA:
24.7		 5vc3A-4otdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 GLY A 808
LEU A 811
LEU A 732
ILE A 851
LEU A 864
 None
 0.91A 5vkqC-4otdA:
undetectable
5vkqD-4otdA:
undetectable		 5vkqC-4otdA:
11.78
5vkqD-4otdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 LEU A 627
ALA A 648
VAL A 685
MET A 701
GLY A 707
 None
 0.58A 5w5vA-4otdA:
13.9		 5w5vA-4otdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 ALA A 723
GLU A 720
LEU A 815
GLY A 808
LEU A 810
 None
 1.44A 5wgqA-4otdA:
undetectable		 5wgqA-4otdA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 6 LEU A 636
PHE A 621
PHE A 623
LEU A 921
 None
None
None
SEP  A 922 ( 4.5A)
 1.17A 5x19P-4otdA:
undetectable		 5x19P-4otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
 None
 0.84A 5y7zA-4otdA:
7.3		 5y7zA-4otdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
VAL A 635
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
 None
 0.84A 5y7zA-4otdA:
7.3		 5y7zA-4otdA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		7 / 12 LEU A 627
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
ASP A 764
 None
 0.95A 5y7zB-4otdA:
26.2		 5y7zB-4otdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 7 PHE A 623
LEU A 618
LEU A 652
GLY A 633
 None
 0.79A 6eu9D-4otdA:
undetectable		 6eu9D-4otdA:
14.33