SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ote'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		3 / 3 GLU A 254
ALA A 249
SER A 246
 None
 0.59A 1errB-4oteA:
undetectable		 1errB-4oteA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.99A 2dyrN-4oteA:
undetectable
2dyrW-4oteA:
undetectable		 2dyrN-4oteA:
17.12
2dyrW-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.94A 2eijN-4oteA:
undetectable
2eijW-4oteA:
undetectable		 2eijN-4oteA:
17.12
2eijW-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.93A 2eilN-4oteA:
undetectable
2eilW-4oteA:
undetectable		 2eilN-4oteA:
17.12
2eilW-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		6 / 10 ALA A 192
LEU A 113
LEU A 151
ILE A 173
PHE A 175
THR A 191
 None
 1.33A 2w9sD-4oteA:
undetectable		 2w9sD-4oteA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		6 / 10 ALA A 192
LEU A 113
LEU A 151
ILE A 173
PHE A 175
THR A 191
 None
 1.33A 2w9sF-4oteA:
undetectable		 2w9sF-4oteA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 10 VAL A 261
ILE A 253
LEU A  43
GLY A  41
ALA A  35
 None
 1.18A 2xf3A-4oteA:
undetectable		 2xf3A-4oteA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.98A 3ablA-4oteA:
undetectable
3ablJ-4oteA:
undetectable		 3ablA-4oteA:
17.12
3ablJ-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.94A 3ag3N-4oteA:
undetectable
3ag3W-4oteA:
undetectable		 3ag3N-4oteA:
17.12
3ag3W-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 10 ALA A 192
LEU A 113
LEU A 152
PHE A 175
THR A 191
 None
 1.06A 3fl9E-4oteA:
undetectable		 3fl9E-4oteA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 VAL A 201
GLY A 259
ILE A 262
PRO A  39
 None
 0.77A 3nu9A-4oteA:
undetectable		 3nu9A-4oteA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 LEU A 205
ASP A 206
ALA A 207
TYR A 116
 None
 1.19A 3rodD-4oteA:
undetectable		 3rodD-4oteA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 SER A 133
ILE A 183
ASN A 134
ASP A 179
 None
 1.13A 4d33A-4oteA:
undetectable		 4d33A-4oteA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 138
ASN A 142
THR A 198
ALA A 111
TYR A  88
 None
None
None
ACT  A 317 ( 4.2A)
None
 1.37A 4dajA-4oteA:
undetectable		 4dajA-4oteA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 11 ASP A 206
VAL A 201
GLY A 259
ILE A 262
PRO A  39
 None
 0.99A 4dqeA-4oteA:
undetectable		 4dqeA-4oteA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 9 GLU A  45
GLY A  41
PRO A  39
GLU A 254
TYR A 107
 ZN  A 306 (-2.2A)
None
None
None
None
 1.23A 4fimA-4oteA:
5.8		 4fimA-4oteA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		3 / 3 LYS A 176
LEU A 178
ALA A 131
 None
 0.60A 4iizA-4oteA:
undetectable		 4iizA-4oteA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 8 LYS A 176
LEU A 178
THR A 129
ALA A 131
 None
 0.60A 4ik6B-4oteA:
undetectable		 4ik6B-4oteA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 LYS A 176
LEU A 178
THR A 129
ALA A 131
 None
 0.94A 4ik7A-4oteA:
undetectable		 4ik7A-4oteA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A 130
PHE A 124
LEU A 146
THR A 214
 None
 1.10A 4mmcA-4oteA:
undetectable		 4mmcA-4oteA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.96A 5iy5A-4oteA:
undetectable
5iy5J-4oteA:
undetectable		 5iy5A-4oteA:
17.12
5iy5J-4oteA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 12 TYR A  66
LEU A  82
GLY A  40
PRO A  39
VAL A  38
 None
 1.44A 5jo9A-4oteA:
undetectable		 5jo9A-4oteA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 12 GLY A 259
ALA A 200
ALA A 207
ASP A 206
TYR A 114
 None
 1.15A 5x7fA-4oteA:
undetectable		 5x7fA-4oteA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 10 VAL A  33
ALA A  35
LEU A 240
LEU A 244
LEU A  58
 None
 0.92A 6f5uA-4oteA:
undetectable
6f5uB-4oteA:
undetectable		 6f5uA-4oteA:
17.14
6f5uB-4oteA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		5 / 10 VAL A  33
ALA A  35
LEU A 240
LEU A 244
LEU A  58
 None
 1.03A 6f6nA-4oteA:
undetectable
6f6nB-4oteA:
undetectable		 6f6nA-4oteA:
17.14
6f6nB-4oteA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ote LIPOPROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.91A 6nmpA-4oteA:
undetectable
6nmpJ-4oteA:
undetectable		 6nmpA-4oteA:
17.12
6nmpJ-4oteA:
14.59