SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4otk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  88
ALA A 118
GLY A 281
ALA A  54
GLU A  60
 None
 0.95A 1kxhA-4otkA:
7.8		 1kxhA-4otkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 156
ILE A 157
VAL A 189
ALA A 185
LEU A 180
 None
 1.15A 1xp0A-4otkA:
undetectable		 1xp0A-4otkA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 224
GLY A  25
GLY A  47
ILE A  46
VAL A 250
 None
 0.96A 2ieoA-4otkA:
undetectable		 2ieoA-4otkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 10 SER A  70
LEU A  44
LEU A  77
ARG A  49
GLU A  76
 None
 1.04A 2j1gE-4otkA:
undetectable
2j1gF-4otkA:
undetectable		 2j1gE-4otkA:
21.77
2j1gF-4otkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 8 SER A  70
LEU A  44
LEU A  77
ARG A  49
 None
 0.85A 2j2pA-4otkA:
undetectable
2j2pB-4otkA:
undetectable		 2j2pA-4otkA:
21.77
2j2pB-4otkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 9 SER A  70
LEU A  44
LEU A  77
ARG A  49
GLU A  76
 None
 1.09A 2j2pD-4otkA:
0.0
2j2pE-4otkA:
0.0		 2j2pD-4otkA:
21.77
2j2pE-4otkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 203
TRP A 226
MET A 260
LEU A 266
 MLI  A 301 (-4.7A)
None
None
None
 1.36A 2oz7A-4otkA:
undetectable		 2oz7A-4otkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 157
LEU A 156
VAL A 145
GLY A 144
 None
 0.71A 2wd9B-4otkA:
2.6		 2wd9B-4otkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 272
TRP A 116
VAL A 145
ASN A 184
TYR A 194
 None
None
None
None
MLI  A 302 (-4.1A)
 1.20A 2y00A-4otkA:
undetectable		 2y00A-4otkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 272
TRP A 116
VAL A 145
ASN A 184
TYR A 194
 None
None
None
None
MLI  A 302 (-4.1A)
 1.19A 2y00B-4otkA:
undetectable		 2y00B-4otkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 272
TRP A 116
VAL A 145
ASN A 184
TYR A 194
 None
None
None
None
MLI  A 302 (-4.1A)
 1.24A 2y01B-4otkA:
undetectable		 2y01B-4otkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 10 CYH A  48
ILE A  46
VAL A 236
GLY A  27
LEU A  44
 None
 1.23A 3em0A-4otkA:
undetectable		 3em0A-4otkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 CYH A  48
ILE A  46
VAL A 236
GLY A  27
LEU A  44
 None
 1.18A 3em0B-4otkA:
undetectable		 3em0B-4otkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 MET A 260
LEU A 263
LEU A 171
LEU A 202
LEU A 230
 None
 1.20A 3erdA-4otkA:
undetectable		 3erdA-4otkA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  27
ALA A  29
ALA A  43
ASP A  52
ILE A  51
 None
MLI  A 302 (-3.7A)
None
None
None
 1.01A 3id6C-4otkA:
undetectable		 3id6C-4otkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 223
TRP A 226
GLY A 264
 None
 0.66A 3l35A-4otkA:
undetectable
3l35H-4otkA:
undetectable		 3l35A-4otkA:
7.32
3l35H-4otkA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 223
TRP A 226
GLY A 264
 None
 0.59A 3l35B-4otkA:
undetectable
3l35K-4otkA:
undetectable		 3l35B-4otkA:
7.32
3l35K-4otkA:
4.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  57
HIS A 115
ASN A 147
TYR A 194
PRO A 276
 MLI  A 302 (-4.4A)
MLI  A 302 (-4.0A)
None
MLI  A 302 (-4.1A)
None
 0.84A 3r58A-4otkA:
38.0		 3r58A-4otkA:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  57
HIS A 115
ASN A 147
TYR A 194
PRO A 276
 MLI  A 302 (-4.4A)
MLI  A 302 (-4.0A)
None
MLI  A 302 (-4.1A)
None
 0.75A 3r8gA-4otkA:
38.0		 3r8gA-4otkA:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		3 / 3 SER A  93
MET A 131
ASP A 102
 None
 0.82A 4mm4B-4otkA:
undetectable		 4mm4B-4otkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 THR A 270
LEU A 223
GLN A 229
LEU A 230
 None
 1.24A 4nc3A-4otkA:
undetectable		 4nc3A-4otkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 235
ASP A  52
SER A 146
ALA A  56
 None
 1.24A 4nedA-4otkA:
undetectable		 4nedA-4otkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  31
ASN A  59
LEU A  26
VAL A  79
 None
 1.00A 4okbA-4otkA:
undetectable		 4okbA-4otkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 5 THR A  53
ALA A  54
THR A  81
TYR A 112
 None
 1.09A 5ecmA-4otkA:
undetectable		 5ecmA-4otkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 THR A  53
ALA A  54
THR A  81
TYR A 112
 None
 1.02A 5ecoA-4otkA:
undetectable		 5ecoA-4otkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  63
LEU A  44
CYH A  48
ASP A  52
 None
 1.45A 5vcvA-4otkA:
undetectable		 5vcvA-4otkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  47
GLU A  45
ILE A 244
GLN A 221
 None
 0.85A 5vlmD-4otkA:
undetectable		 5vlmD-4otkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  44
ARG A  49
ILE A  51
GLY A  25
ILE A 244
LEU A 113
 None
 1.33A 5ycnA-4otkA:
undetectable		 5ycnA-4otkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 169
VAL A 145
ILE A 153
THR A 163
 None
 0.97A 6cduF-4otkA:
undetectable
6cduG-4otkA:
undetectable		 6cduF-4otkA:
22.46
6cduG-4otkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4otk MYCOBACTERIAL ENZYME
RV2971
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 103
SER A 100
ALA A  84
THR A 282
 None
 1.12A 6ma6A-4otkA:
undetectable		 6ma6A-4otkA:
11.39