SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4otm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQE_A_DVAA6_0 (MINI-GRAMICIDIN A)	4otm	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	3 / 3	ALA A1566 VAL A1561 TRP A1560	None	0.77A	1kqeA-4otmA: undetectable 1kqeE-4otmA: undetectable	1kqeA-4otmA: 7.14 1kqeE-4otmA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQE_B_DVAB6_0 (MINI-GRAMICIDIN A)	4otm	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	3 / 3	ALA A1566 VAL A1561 TRP A1560	None	0.76A	1kqeB-4otmA: undetectable 1kqeD-4otmA: undetectable	1kqeB-4otmA: 7.14 1kqeD-4otmA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQE_D_DVAD6_0 (MINI-GRAMICIDIN A)	4otm	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	3 / 3	TRP A1560 ALA A1566 VAL A1561	None	0.78A	1kqeB-4otmA: undetectable 1kqeD-4otmA: undetectable	1kqeB-4otmA: 7.14 1kqeD-4otmA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQE_E_DVAE6_0 (MINI-GRAMICIDIN A)	4otm	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	3 / 3	TRP A1560 ALA A1566 VAL A1561	None	0.76A	1kqeA-4otmA: undetectable 1kqeE-4otmA: undetectable	1kqeA-4otmA: 7.14 1kqeE-4otmA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A50_A_VD3A2001_1 (VITAMIN D HYDROXYLASE)	4otm	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	5 / 12	ILE A1627 LEU A1644 ILE A1655 ALA A1642 LEU A1601	None	1.14A	3a50A-4otmA: undetectable	3a50A-4otmA: 15.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KQE_A_DVAA6_0","MINI-GRAMICIDIN A","4otm","SERINE\/THREONINE-PROTEIN KINASE GCN2","Saccharomyces cerevisiae",3,"ALA A1566;VAL A1561;TRP A1560","None","0.77A","1kqeA-4otmA:undetectable;1kqeE-4otmA:undetectable","1kqeA-4otmA:7.14;1kqeE-4otmA:7.14"],["1KQE_B_DVAB6_0","MINI-GRAMICIDIN A","4otm","SERINE\/THREONINE-PROTEIN KINASE GCN2","Saccharomyces cerevisiae",3,"ALA A1566;VAL A1561;TRP A1560","None","0.76A","1kqeB-4otmA:undetectable;1kqeD-4otmA:undetectable","1kqeB-4otmA:7.14;1kqeD-4otmA:7.14"],["1KQE_D_DVAD6_0","MINI-GRAMICIDIN A","4otm","SERINE\/THREONINE-PROTEIN KINASE GCN2","Saccharomyces cerevisiae",3,"TRP A1560;ALA A1566;VAL A1561","None","0.78A","1kqeB-4otmA:undetectable;1kqeD-4otmA:undetectable","1kqeB-4otmA:7.14;1kqeD-4otmA:7.14"],["1KQE_E_DVAE6_0","MINI-GRAMICIDIN A","4otm","SERINE\/THREONINE-PROTEIN KINASE GCN2","Saccharomyces cerevisiae",3,"TRP A1560;ALA A1566;VAL A1561","None","0.76A","1kqeA-4otmA:undetectable;1kqeE-4otmA:undetectable","1kqeA-4otmA:7.14;1kqeE-4otmA:7.14"],["3A50_A_VD3A2001_1","VITAMIN D HYDROXYLASE","4otm","SERINE\/THREONINE-PROTEIN KINASE GCN2","Saccharomyces cerevisiae",5,"ILE A1627;LEU A1644;ILE A1655;ALA A1642;LEU A1601","None","1.14A","3a50A-4otmA:undetectable","3a50A-4otmA:15.17"]]