SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4otn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4otn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 4
(Mus
musculus) 		4 / 6 LEU A1557
GLN A1552
GLU A1550
ILE A1551
 None
 1.04A 2fcnA-4otnA:
undetectable
2fcnB-4otnA:
undetectable		 2fcnA-4otnA:
22.66
2fcnB-4otnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4otn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 4
(Mus
musculus) 		4 / 6 LEU A1589
PHE A1586
ILE A1622
PHE A1635
 None
 1.03A 3ko0S-4otnA:
undetectable		 3ko0S-4otnA:
23.61