SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4otp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		5 / 11 VAL A 194
ALA A 206
LYS A 208
LEU A 331
ILE A 340
 ADP  A 501 (-4.3A)
ADP  A 501 ( 4.0A)
ADP  A 501 (-3.0A)
None
PHD  A 341 (-3.5A)
 0.37A 4iaaA-4otpA:
13.4		 4iaaA-4otpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		4 / 8 TYR A 304
ASP A 421
GLU A 383
ARG A 409
 None
 1.35A 4kr4C-4otpA:
undetectable		 4kr4C-4otpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		3 / 3 ILE A 268
MET A 173
ARG A 176
 None
 0.88A 4lnwA-4otpA:
undetectable		 4lnwA-4otpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		3 / 3 ILE A 268
MET A 173
ARG A 176
 None
 0.89A 4lnxA-4otpA:
undetectable		 4lnxA-4otpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		4 / 5 CYH A 264
ILE A 339
LEU A 254
HIS A 322
 None
None
None
PHD  A 341 ( 3.9A)
 1.46A 5hrqC-4otpA:
undetectable
5hrqD-4otpA:
undetectable
5hrqL-4otpA:
undetectable		 5hrqC-4otpA:
4.58
5hrqD-4otpA:
4.83
5hrqL-4otpA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		3 / 3 GLY A 177
VAL A 276
MET A 269
 None
 0.62A 5ycpA-4otpA:
undetectable		 5ycpA-4otpA:
12.25