SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ou2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A 344
VAL A 353
VAL A 373
GLN A 387
 None
 1.13A 1e7aB-4ou2A:
undetectable		 1e7aB-4ou2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		6 / 12 PHE A 224
ILE A 165
GLY A 230
ILE A 221
THR A 234
PHE A 244
 None
NAD  A 601 (-4.2A)
NAD  A 601 (-3.7A)
None
NAD  A 601 ( 4.2A)
NAD  A 601 (-4.5A)
 1.46A 1nv8B-4ou2A:
4.2		 1nv8B-4ou2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 204
LEU A 172
ASN A 124
ALA A 180
ALA A 184
 None
 1.16A 2bm9C-4ou2A:
3.1		 2bm9C-4ou2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 183
VAL A 179
THR A 243
VAL A 164
GLY A 160
 None
 1.12A 2cbrA-4ou2A:
undetectable		 2cbrA-4ou2A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 GLY A  90
ILE A  87
ALA A 211
VAL A 213
PHE A 218
 None
 1.33A 2drdA-4ou2A:
undetectable		 2drdA-4ou2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 223
GLU A  51
ASN A  22
ILE A 221
 None
 0.79A 2dtjA-4ou2A:
undetectable
2dtjB-4ou2A:
undetectable		 2dtjA-4ou2A:
15.94
2dtjB-4ou2A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 ASN A  22
ILE A 221
GLY A 223
GLU A  51
ALA A 229
 None
 0.94A 2dtjA-4ou2A:
undetectable
2dtjB-4ou2A:
undetectable		 2dtjA-4ou2A:
15.94
2dtjB-4ou2A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 SER A 428
SER A 476
LEU A 432
GLY A 431
 None
None
NAD  A 601 (-4.3A)
None
 0.96A 2j2pA-4ou2A:
undetectable
2j2pC-4ou2A:
undetectable		 2j2pA-4ou2A:
18.38
2j2pC-4ou2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 SER A 428
SER A 476
LEU A 432
GLY A 431
 None
None
NAD  A 601 (-4.3A)
None
 0.94A 2j2pD-4ou2A:
undetectable
2j2pF-4ou2A:
undetectable		 2j2pD-4ou2A:
18.38
2j2pF-4ou2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 175
ASN A 187
VAL A 189
GLY A 163
ALA A 191
 None
 1.09A 2x2iA-4ou2A:
undetectable		 2x2iA-4ou2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 183
VAL A 164
GLY A 163
LEU A 242
ILE A 221
 None
 0.98A 3ijdA-4ou2A:
undetectable		 3ijdA-4ou2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 183
VAL A 164
GLY A 163
LEU A 242
ILE A 221
 None
 1.06A 3ijdB-4ou2A:
undetectable		 3ijdB-4ou2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A 130
ARG A 126
ALA A 129
 None
 0.79A 3mbgC-4ou2A:
undetectable		 3mbgC-4ou2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 184
LEU A 183
VAL A 179
ALA A 201
LEU A 172
 None
 1.30A 3ozuA-4ou2A:
4.8		 3ozuA-4ou2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A 349
SER A 197
ASN A 297
 None
 0.83A 3s8pB-4ou2A:
undetectable		 3s8pB-4ou2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A  93
PHE A  98
LEU A 172
GLY A 212
PHE A 218
 None
 1.25A 4kykA-4ou2A:
undetectable
4kykB-4ou2A:
undetectable		 4kykA-4ou2A:
15.46
4kykB-4ou2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 ALA A 274
ILE A 451
VAL A 447
ALA A 435
ILE A 436
 None
 0.99A 4lbgB-4ou2A:
3.4		 4lbgB-4ou2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ARG A  80
GLY A 212
ALA A 211
ASP A 210
ILE A  87
 None
 1.10A 4njvA-4ou2A:
undetectable		 4njvA-4ou2A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLY A 342
PRO A 343
GLN A 300
 None
 0.37A 4oltB-4ou2A:
1.1		 4oltB-4ou2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLY A 342
PRO A 343
GLN A 300
 None
 0.28A 4qwpB-4ou2A:
undetectable		 4qwpB-4ou2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASP A  89
PHE A  98
ILE A  91
ALA A 121
PHE A 125
 None
 1.29A 4wh5A-4ou2A:
undetectable		 4wh5A-4ou2A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 ILE A 436
PHE A 278
ILE A 422
GLU A 418
 None
 1.15A 4zzcA-4ou2A:
undetectable
4zzcB-4ou2A:
undetectable		 4zzcA-4ou2A:
21.65
4zzcB-4ou2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A 349
SER A 197
ASN A 297
 None
 0.84A 5cprB-4ou2A:
undetectable		 5cprB-4ou2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 7 GLU A 404
GLY A 246
GLY A 251
TYR A 430
ALA A 268
 NAD  A 601 (-2.8A)
NAD  A 601 (-3.0A)
None
None
NAD  A 601 (-3.2A)
 1.25A 5e26C-4ou2A:
undetectable
5e26D-4ou2A:
undetectable		 5e26C-4ou2A:
22.02
5e26D-4ou2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 LYS A  74
GLN A  65
ASN A  66
 None
 1.07A 5l2tA-4ou2A:
undetectable		 5l2tA-4ou2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 472
VAL A 258
LEU A 242
GLY A 251
SER A 248
 None
 1.19A 5vooE-4ou2A:
undetectable		 5vooE-4ou2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 472
VAL A 258
LEU A 242
GLY A 251
SER A 248
 None
 1.18A 5vooF-4ou2A:
undetectable		 5vooF-4ou2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 ILE A 254
LEU A 269
GLY A 246
TYR A 430
 None
None
NAD  A 601 (-3.0A)
None
 0.88A 5x5qF-4ou2A:
undetectable		 5x5qF-4ou2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 GLY A 107
VAL A 103
GLU A 102
GLY A 342
PRO A 334
 None
 1.06A 5zniA-4ou2A:
1.6		 5zniA-4ou2A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 ASP A 396
PHE A 315
ASN A 273
TYR A 309
 None
 1.08A 6a93B-4ou2A:
undetectable		 6a93B-4ou2A:
23.72