SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.32A 1mj2B-4ouaB:
undetectable		 1mj2B-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.33A 1mj2B-4ouaA:
undetectable		 1mj2B-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.33A 1mj2D-4ouaB:
undetectable		 1mj2D-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.35A 1mj2D-4ouaA:
undetectable		 1mj2D-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.31A 1mjoB-4ouaB:
undetectable		 1mjoB-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.32A 1mjoB-4ouaA:
undetectable		 1mjoB-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.37A 1mjoA-4ouaB:
undetectable		 1mjoA-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.37A 1mjoA-4ouaA:
undetectable		 1mjoA-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.31A 1mjoD-4ouaB:
undetectable		 1mjoD-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.33A 1mjoD-4ouaA:
undetectable		 1mjoD-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 PRO B 538
LEU B 529
HIS B 243
ARG B 527
 None
 1.31A 1oafA-4ouaB:
undetectable		 1oafA-4ouaB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 10 HIS A 282
VAL A 258
LEU A 205
LEU A 138
THR A 134
 CU1  A 402 (-3.0A)
None
None
None
None
 1.19A 1rj6B-4ouaA:
undetectable		 1rj6B-4ouaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.61A 1rjoA-4ouaB:
undetectable		 1rjoA-4ouaB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.69A 1rjoA-4ouaA:
undetectable		 1rjoA-4ouaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.65A 1rkyA-4ouaB:
undetectable		 1rkyA-4ouaB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
GLU A 248
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
None
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 1.33A 1uttA-4ouaA:
undetectable		 1uttA-4ouaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 ILE B 174
ILE B  56
ILE B  97
PHE B 275
 None
 0.89A 1uwjA-4ouaB:
undetectable		 1uwjA-4ouaB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 ILE A 174
ILE A  56
ILE A  97
PHE A 275
 None
 0.89A 1uwjA-4ouaA:
undetectable		 1uwjA-4ouaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.63A 1w2zA-4ouaB:
undetectable		 1w2zA-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 1w2zA-4ouaA:
undetectable		 1w2zA-4ouaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 1w2zB-4ouaB:
undetectable		 1w2zB-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.63A 1w2zC-4ouaB:
undetectable		 1w2zC-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 1w2zC-4ouaA:
undetectable		 1w2zC-4ouaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 1w2zD-4ouaB:
undetectable		 1w2zD-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 TRP B 413
LEU B 394
LYS B 398
 None
 1.31A 1yajK-4ouaB:
undetectable		 1yajK-4ouaB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B 129
LEU B 281
GLN B  40
TYR B  98
 None
 1.11A 1yc2B-4ouaB:
undetectable
1yc2C-4ouaB:
undetectable		 1yc2B-4ouaB:
18.35
1yc2C-4ouaB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN A 129
LEU A 281
GLN A  40
TYR A  98
 None
 1.07A 1yc2B-4ouaA:
undetectable
1yc2C-4ouaA:
undetectable		 1yc2B-4ouaA:
21.20
1yc2C-4ouaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 LYS B 208
ASP B 276
ASN B 193
 None
 0.91A 2bm9A-4ouaB:
undetectable		 2bm9A-4ouaB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 LYS A 208
ASP A 276
ASN A 193
 None
 0.89A 2bm9A-4ouaA:
undetectable		 2bm9A-4ouaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 PHE B 257
ILE B 522
GLY B 475
ASN B 245
ILE B 451
 None
 1.28A 2e7fA-4ouaB:
undetectable		 2e7fA-4ouaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 PHE B 257
ILE B 522
GLY B 475
ASN B 245
ILE B 451
 None
 1.31A 2e7fB-4ouaB:
undetectable		 2e7fB-4ouaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 10 GLY B 207
LEU B 211
LEU B 209
PHE B 257
TYR B 447
 None
 1.07A 2f8dB-4ouaB:
undetectable		 2f8dB-4ouaB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus;
Agaricus
bisporus) 		4 / 8 THR A 158
GLY B 360
THR A 161
ILE A 160
 None
 0.81A 2f9wA-4ouaA:
undetectable
2f9wB-4ouaA:
undetectable		 2f9wA-4ouaA:
20.05
2f9wB-4ouaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 ASP B 253
HIS B  91
HIS B  57
HIS B  82
LEU B 247
 None
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.16A 2jihA-4ouaB:
undetectable		 2jihA-4ouaB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 11 LEU A 209
THR A 134
ILE A 145
MET A 267
LEU A 247
 None
 1.47A 2n27A-4ouaA:
0.0		 2n27A-4ouaA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.16A 2obvA-4ouaB:
undetectable		 2obvA-4ouaB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.16A 2obvA-4ouaA:
undetectable		 2obvA-4ouaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeA-4ouaB:
undetectable		 2oqeA-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeA-4ouaA:
undetectable		 2oqeA-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeB-4ouaB:
undetectable		 2oqeB-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeB-4ouaA:
undetectable		 2oqeB-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeC-4ouaB:
undetectable		 2oqeC-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 2oqeC-4ouaA:
undetectable		 2oqeC-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.65A 2oqeD-4ouaB:
undetectable		 2oqeD-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeD-4ouaA:
undetectable		 2oqeD-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeF-4ouaB:
undetectable		 2oqeF-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 2oqeF-4ouaA:
undetectable		 2oqeF-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.16A 2p02A-4ouaB:
undetectable		 2p02A-4ouaB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.16A 2p02A-4ouaA:
undetectable		 2p02A-4ouaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ALA A 106
LEU A  31
PHE A  28
ALA A 123
GLY A  12
 None
 1.08A 2ve3A-4ouaA:
undetectable		 2ve3A-4ouaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.59A 2w0qA-4ouaB:
undetectable		 2w0qA-4ouaB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.67A 2w0qA-4ouaA:
undetectable		 2w0qA-4ouaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.62A 2w0qB-4ouaB:
undetectable		 2w0qB-4ouaB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.70A 2w0qB-4ouaA:
undetectable		 2w0qB-4ouaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
VAL B 286
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.94A 2wkoF-4ouaB:
undetectable		 2wkoF-4ouaB:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 283
HIS A 282
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
 0.77A 3bvdA-4ouaA:
undetectable		 3bvdA-4ouaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.67A 3hiiA-4ouaB:
undetectable		 3hiiA-4ouaB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.73A 3hiiA-4ouaA:
undetectable		 3hiiA-4ouaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.67A 3hiiB-4ouaB:
undetectable		 3hiiB-4ouaB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR B 268
HIS B 255
HIS B 251
HIS B 282
ILE B 278
 None
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
None
None
 1.34A 3hy7A-4ouaB:
undetectable		 3hy7A-4ouaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR A 268
HIS A 255
HIS A 251
HIS A 282
ILE A 278
 None
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.0A)
None
 1.33A 3hy7A-4ouaA:
undetectable		 3hy7A-4ouaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR B 268
HIS B 255
HIS B 251
HIS B 282
ILE B 278
 None
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
None
None
 1.31A 3hy7B-4ouaB:
undetectable		 3hy7B-4ouaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 ILE B  33
PHE B  29
ASP B  25
GLU B  26
 None
 1.18A 3kp6A-4ouaB:
undetectable
3kp6B-4ouaB:
undetectable		 3kp6A-4ouaB:
14.50
3kp6B-4ouaB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  57
HIS B  91
HIS B  82
ASP B 252
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.13A 3nvcA-4ouaB:
undetectable		 3nvcA-4ouaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  91
HIS B  57
HIS B 283
ASP B 252
 CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
None
 0.95A 3nvcA-4ouaB:
undetectable		 3nvcA-4ouaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  57
HIS A  91
HIS A  82
ASP A 252
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
None
 1.14A 3nvcA-4ouaA:
undetectable		 3nvcA-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  91
HIS A  57
HIS A 283
ASP A 252
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
None
 1.01A 3nvcA-4ouaA:
undetectable		 3nvcA-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP B 133
ILE B 254
ILE B 370
ASP B 354
ARG B 288
 None
 1.20A 3phaB-4ouaB:
undetectable		 3phaB-4ouaB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP B 133
ILE B 254
ILE B 370
ASP B 354
ARG B 288
 None
 1.41A 3phaB-4ouaB:
undetectable		 3phaB-4ouaB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP A 133
ILE A 254
ILE A 370
ASP A 354
ARG A 288
 None
 1.22A 3phaB-4ouaA:
undetectable		 3phaB-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP A 133
ILE A 254
ILE A 370
ASP A 354
ARG A 288
 None
 1.34A 3phaB-4ouaA:
undetectable		 3phaB-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP B 133
ILE B 254
ILE B 370
ASP B 354
ARG B 288
 None
 1.42A 3phaC-4ouaB:
undetectable		 3phaC-4ouaB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP A 133
ILE A 254
ILE A 370
ASP A 354
ARG A 288
 None
 1.35A 3phaC-4ouaA:
undetectable		 3phaC-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ASP A 133
ILE A 254
ILE A 370
ASP A 354
ARG A 288
 None
 1.31A 3phaD-4ouaA:
undetectable		 3phaD-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 10 GLU B 218
ARG B 481
PHE B 482
LEU B 504
GLU B 212
 None
 1.23A 3qeoA-4ouaB:
undetectable		 3qeoA-4ouaB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.32A 3qpkA-4ouaB:
undetectable		 3qpkA-4ouaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.31A 3qpkA-4ouaA:
undetectable		 3qpkA-4ouaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 3qpkB-4ouaB:
undetectable		 3qpkB-4ouaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.29A 3qpkB-4ouaA:
undetectable		 3qpkB-4ouaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 ARG A  34
ARG A 163
GLY B   8
VAL B   7
GLU B 331
 None
None
NA  B 605 ( 3.9A)
None
None
 1.46A 3u40D-4ouaA:
undetectable
3u40E-4ouaA:
undetectable		 3u40D-4ouaA:
19.12
3u40E-4ouaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.13A 4cevA-4ouaB:
undetectable
4cevB-4ouaB:
undetectable		 4cevA-4ouaB:
18.89
4cevB-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.16A 4cevA-4ouaA:
undetectable
4cevB-4ouaA:
undetectable		 4cevA-4ouaA:
21.31
4cevB-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ASP B 287
ARG B  92
HIS B  91
LEU B 247
 None
None
CU1  B 601 (-3.2A)
None
 1.11A 4cevA-4ouaB:
undetectable
4cevC-4ouaB:
undetectable		 4cevA-4ouaB:
18.89
4cevC-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ASP A 287
ARG A  92
HIS A  91
LEU A 247
 None
None
CU1  A 401 (-3.3A)
None
 1.14A 4cevA-4ouaA:
undetectable
4cevC-4ouaA:
undetectable		 4cevA-4ouaA:
21.31
4cevC-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.11A 4cevD-4ouaB:
undetectable
4cevE-4ouaB:
undetectable		 4cevD-4ouaB:
18.89
4cevE-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.15A 4cevD-4ouaA:
undetectable
4cevE-4ouaA:
undetectable		 4cevD-4ouaA:
21.31
4cevE-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.12A 4cevE-4ouaB:
undetectable
4cevF-4ouaB:
undetectable		 4cevE-4ouaB:
18.89
4cevF-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.15A 4cevE-4ouaA:
undetectable
4cevF-4ouaA:
undetectable		 4cevE-4ouaA:
21.31
4cevF-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 12 PHE B 257
ILE B 522
GLY B 475
ASN B 245
ILE B 451
 None
 1.27A 4djfA-4ouaB:
undetectable		 4djfA-4ouaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.39A 4ig5A-4ouaB:
0.0		 4ig5A-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.38A 4ig5B-4ouaB:
0.0		 4ig5B-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.20A 4kttA-4ouaB:
undetectable		 4kttA-4ouaB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.19A 4kttA-4ouaA:
undetectable		 4kttA-4ouaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.18A 4kttC-4ouaB:
undetectable		 4kttC-4ouaB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.17A 4kttC-4ouaA:
undetectable		 4kttC-4ouaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 HIS A 251
HIS A 283
HIS A 255
PHE A 239
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.1A)
None
 0.88A 4n16A-4ouaA:
undetectable		 4n16A-4ouaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.21A 4ndnA-4ouaB:
undetectable		 4ndnA-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.20A 4ndnA-4ouaA:
undetectable		 4ndnA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.19A 4ndnC-4ouaB:
undetectable		 4ndnC-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.19A 4ndnC-4ouaA:
undetectable		 4ndnC-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 PHE B 476
HIS B 243
LEU B 529
PRO B 538
 None
 1.16A 4o8zA-4ouaB:
undetectable		 4o8zA-4ouaB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.11A 4odjA-4ouaB:
undetectable		 4odjA-4ouaB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.10A 4odjA-4ouaA:
undetectable		 4odjA-4ouaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.46A 4p6sA-4ouaB:
21.0		 4p6sA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.21A 4p6sA-4ouaB:
21.0		 4p6sA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.46A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.22A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.49A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.44A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
 0.38A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B  82
HIS B  57
HIS B 255
HIS B 251
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
 0.99A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
 0.98A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
 0.37A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A  82
HIS A  57
HIS A 255
HIS A 251
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
 0.97A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.96A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 GLU A 238
THR A 242
HIS A 243
 None
 0.86A 4q15B-4ouaA:
undetectable		 4q15B-4ouaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 ASP A 354
SER A 351
ARG A 288
TRP A 301
 None
 1.06A 4uhxA-4ouaA:
undetectable		 4uhxA-4ouaA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 SER B 311
TYR B  75
ARG B 466
GLU B 307
 None
 1.42A 4xzkA-4ouaB:
undetectable		 4xzkA-4ouaB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 GLU A 238
THR A 242
HIS A 243
 None
 0.81A 4ydqB-4ouaA:
undetectable		 4ydqB-4ouaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.19A 5a1iA-4ouaB:
undetectable		 5a1iA-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.18A 5a1iA-4ouaA:
undetectable		 5a1iA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.19A 5a1iA-4ouaB:
undetectable		 5a1iA-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.18A 5a1iA-4ouaA:
undetectable		 5a1iA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 LEU B 205
ILE B 206
PRO B 140
LEU B 138
 None
 0.88A 5eb3A-4ouaB:
undetectable		 5eb3A-4ouaB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 LEU A 205
ILE A 206
PRO A 140
LEU A 138
 None
 0.92A 5eb3A-4ouaA:
undetectable		 5eb3A-4ouaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.33A 5ff1A-4ouaB:
0.0		 5ff1A-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.33A 5ff1A-4ouaB:
0.0		 5ff1A-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.34A 5ff1B-4ouaB:
undetectable		 5ff1B-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 GLN B  84
ARG B 308
GLU B 307
LEU B 320
 None
 1.34A 5ff1B-4ouaB:
undetectable		 5ff1B-4ouaB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 12 GLY A 135
LEU A 205
ILE A 263
GLY A 265
THR A 268
 None
 1.27A 5fsaB-4ouaA:
0.4		 5fsaB-4ouaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.46A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.45A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B 255
HIS B 283
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.1A)
None
 0.87A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.45A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.20A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.43A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.48A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.41A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.21A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.49A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.39A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.21A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.47A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.46A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.48A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.20A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.45A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.47A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.20A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.43A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.48A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  82
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.1A)
None
 0.39A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  91
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-3.1A)
None
 1.33A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 255
HIS B 251
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.03A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 255
HIS B 283
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.1A)
None
 0.90A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  82
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.1A)
None
 0.41A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  91
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.1A)
None
 1.28A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 255
HIS A 251
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
None
 1.02A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 255
HIS A 283
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.2A)
None
 0.81A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 GLY A  11
GLN A 103
LYS A  14
 None
 0.93A 5imsB-4ouaA:
undetectable		 5imsB-4ouaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.31A 5mejA-4ouaA:
undetectable		 5mejA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.30A 5mewA-4ouaA:
undetectable		 5mewA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.32A 5mhuA-4ouaA:
undetectable		 5mhuA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.32A 5mhvA-4ouaA:
undetectable		 5mhvA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.83A 5mhwA-4ouaB:
undetectable		 5mhwA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.81A 5mhwA-4ouaA:
undetectable		 5mhwA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhxA-4ouaB:
undetectable		 5mhxA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhxA-4ouaA:
undetectable		 5mhxA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhyA-4ouaB:
undetectable		 5mhyA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhyA-4ouaA:
undetectable		 5mhyA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhzA-4ouaB:
undetectable		 5mhzA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhzA-4ouaA:
undetectable		 5mhzA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mi1A-4ouaB:
undetectable		 5mi1A-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mi1A-4ouaA:
undetectable		 5mi1A-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mi2A-4ouaB:
undetectable		 5mi2A-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mi2A-4ouaA:
undetectable		 5mi2A-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5miaA-4ouaB:
undetectable		 5miaA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5miaA-4ouaA:
undetectable		 5miaA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mibA-4ouaB:
undetectable		 5mibA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mibA-4ouaA:
undetectable		 5mibA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5micA-4ouaB:
undetectable		 5micA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5micA-4ouaA:
undetectable		 5micA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5midA-4ouaB:
undetectable		 5midA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5midA-4ouaA:
undetectable		 5midA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mieA-4ouaB:
undetectable		 5mieA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mieA-4ouaA:
undetectable		 5mieA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 5migA-4ouaB:
undetectable		 5migA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.30A 5migA-4ouaA:
undetectable		 5migA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  91
ASP B 252
HIS B 236
HIS B 251
 CU1  B 601 (-3.2A)
None
None
CU1  B 602 (-3.2A)
 1.06A 5nelB-4ouaB:
undetectable
5nelC-4ouaB:
undetectable		 5nelB-4ouaB:
19.49
5nelC-4ouaB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  91
ASP A 252
HIS A 236
HIS A 251
 CU1  A 401 (-3.3A)
None
None
CU1  A 402 (-3.0A)
 1.06A 5nelB-4ouaA:
undetectable
5nelC-4ouaA:
undetectable		 5nelB-4ouaA:
20.89
5nelC-4ouaA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 VAL A  73
TYR A  79
GLU A 327
LEU A   3
 None
None
None
SAC  A   2 ( 4.1A)
 1.15A 5umwB-4ouaA:
undetectable
5umwE-4ouaA:
undetectable		 5umwB-4ouaA:
11.26
5umwE-4ouaA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 LEU B   3
VAL B  73
TYR B  79
GLU B 327
 SAC  B   2 ( 4.0A)
None
None
None
 1.16A 5umwA-4ouaB:
undetectable
5umwF-4ouaB:
undetectable		 5umwA-4ouaB:
9.07
5umwF-4ouaB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 LEU A   3
VAL A  73
TYR A  79
GLU A 327
 SAC  A   2 ( 4.1A)
None
None
None
 1.09A 5umwA-4ouaA:
undetectable
5umwF-4ouaA:
undetectable		 5umwA-4ouaA:
11.26
5umwF-4ouaA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
CYH B  80
HIS B  82
HIS B  91
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
 0.15A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
CYH A  80
HIS A  82
HIS A  91
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
 0.16A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 251
HIS B 255
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
 0.27A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 255
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
 0.33A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  82
PHE B  87
HIS B  91
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
CU1  B 601 (-3.2A)
 1.05A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B 251
HIS B 255
PHE B 279
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-4.5A)
None
CU1  B 602 (-3.0A)
 0.22A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  82
PHE A  87
HIS A  91
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
None
CU1  A 401 (-3.3A)
 1.03A 5zrdB-4ouaA:
34.0		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 251
HIS A 255
PHE A 279
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-4.8A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.27A 5zrdB-4ouaA:
34.0		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.39A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.04A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.36A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 0.99A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B 251
HIS B 255
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.20A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A 251
HIS A 255
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.29A 5zrdC-4ouaA:
28.0		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.40A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.07A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.36A 5zrdC-4ouaA:
28.1		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 1.03A 5zrdC-4ouaA:
28.1		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.41A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.04A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.38A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 1.00A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B 251
HIS B 255
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.19A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A 251
HIS A 255
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.26A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 TYR B 506
ALA B 417
LEU B 520
 None
 0.69A 6d9kF-4ouaB:
undetectable		 6d9kF-4ouaB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.21A 6fbnB-4ouaB:
undetectable		 6fbnB-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.20A 6fbnB-4ouaA:
undetectable		 6fbnB-4ouaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.18A 6fboA-4ouaB:
undetectable		 6fboA-4ouaB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.17A 6fboA-4ouaA:
undetectable		 6fboA-4ouaA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.16A 6fcbA-4ouaB:
undetectable		 6fcbA-4ouaB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.14A 6fcbA-4ouaA:
undetectable		 6fcbA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.15A 6fcdA-4ouaB:
undetectable		 6fcdA-4ouaB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.14A 6fcdA-4ouaA:
undetectable		 6fcdA-4ouaA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.19A 6g6rA-4ouaB:
undetectable		 6g6rA-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.17A 6g6rA-4ouaA:
undetectable		 6g6rA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 TYR B 378
GLY B 379
HIS B 373
ASP B 354
 None
None
TRS  B 606 (-3.6A)
None
 1.26A 6gh9A-4ouaB:
undetectable		 6gh9A-4ouaB:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 283
HIS A 282
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
 0.76A 6giqa-4ouaA:
undetectable		 6giqa-4ouaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 LEU B 224
THR B 220
GLY B 135
ARG B 377
 None
None
None
TRS  B 606 (-4.1A)
 1.36A 6gtqB-4ouaB:
undetectable
6gtqD-4ouaB:
undetectable		 6gtqB-4ouaB:
14.36
6gtqD-4ouaB:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 ARG B 527
PHE B 490
PHE B 226
 None
 1.08A 6nknC-4ouaB:
undetectable
6nknJ-4ouaB:
undetectable		 6nknC-4ouaB:
17.41
6nknJ-4ouaB:
7.37