SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
GLY B 198
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.59A 1ffyA-4oudB:
5.1		 1ffyA-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 HIS B  66
LEU B  29
ALA B  26
LEU B  25
 HIS  B  66 ( 1.0A)
LEU  B  29 ( 0.6A)
ALA  B  26 ( 0.0A)
LEU  B  25 ( 0.6A)
 0.75A 1hwiD-4oudB:
undetectable		 1hwiD-4oudB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 11 GLY B  39
HIS B  48
HIS B  51
GLY B 198
ASP B 200
GLN B 201
ILE B 228
 GLY  B  39 ( 0.0A)
HIS  B  48 ( 1.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
ILE  B 228 ( 0.7A)
 0.67A 1jzsA-4oudB:
1.1		 1jzsA-4oudB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.75A 1pg2A-4oudB:
8.2		 1pg2A-4oudB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY B  50
HIS B  48
GLY B 198
ASP B 200
GLN B 201
 GLY  B  50 ( 0.0A)
HIS  B  48 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 1.02A 1qu2A-4oudB:
5.1		 1qu2A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 12 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.82A 1qu2A-4oudB:
5.1		 1qu2A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
HIS B  51
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.88A 1qu3A-4oudB:
undetectable		 1qu3A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU B 194
LEU B  36
ALA B  35
LEU B  29
THR B 212
 LEU  B 194 ( 0.6A)
LEU  B  36 ( 0.6A)
ALA  B  35 ( 0.0A)
LEU  B  29 ( 0.6A)
THR  B 212 ( 0.8A)
 1.23A 2aa6A-4oudB:
undetectable		 2aa6A-4oudB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.75A 2x1lA-4oudB:
8.8		 2x1lA-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.70A 2x1lB-4oudB:
9.2		 2x1lB-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.71A 2x1lC-4oudB:
9.3		 2x1lC-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ASN B 126
TRP B 129
ASP B  41
 ASN  B 126 ( 0.6A)
TRP  B 129 ( 0.5A)
ASP  B  41 ( 0.6A)
 0.80A 4a7tA-4oudB:
undetectable
4a7tF-4oudB:
undetectable		 4a7tA-4oudB:
18.31
4a7tF-4oudB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 SER B 293
ASP B 290
GLN B 300
 SER  B 293 ( 0.0A)
ASP  B 290 ( 0.6A)
GLN  B 300 ( 0.6A)
 0.88A 4oltA-4oudB:
undetectable
4oltB-4oudB:
undetectable		 4oltA-4oudB:
20.60
4oltB-4oudB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLN B 300
SER B 293
ASP B 290
 GLN  B 300 ( 0.6A)
SER  B 293 ( 0.0A)
ASP  B 290 ( 0.6A)
 0.96A 4qwpA-4oudB:
undetectable
4qwpB-4oudB:
undetectable		 4qwpA-4oudB:
20.15
4qwpB-4oudB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ALA B  49
ARG B 309
GLY B 313
GLU B 314
 ALA  B  49 ( 0.0A)
ARG  B 309 ( 0.6A)
GLY  B 313 ( 0.0A)
GLU  B 314 ( 0.5A)
 0.96A 5bs8A-4oudB:
undetectable
5bs8B-4oudB:
2.9
5bs8C-4oudB:
undetectable		 5bs8A-4oudB:
22.39
5bs8B-4oudB:
22.14
5bs8C-4oudB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ALA B  49
ARG B 309
GLY B 313
GLU B 314
 ALA  B  49 ( 0.0A)
ARG  B 309 ( 0.6A)
GLY  B 313 ( 0.0A)
GLU  B 314 ( 0.5A)
 0.96A 5btdA-4oudB:
undetectable
5btdB-4oudB:
3.0
5btdC-4oudB:
undetectable		 5btdA-4oudB:
22.39
5btdB-4oudB:
22.14
5btdC-4oudB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ALA B  49
ARG B 309
GLY B 313
GLU B 314
 ALA  B  49 ( 0.0A)
ARG  B 309 ( 0.6A)
GLY  B 313 ( 0.0A)
GLU  B 314 ( 0.5A)
 0.98A 5btdA-4oudB:
undetectable
5btdC-4oudB:
undetectable
5btdD-4oudB:
2.8		 5btdA-4oudB:
22.39
5btdC-4oudB:
22.39
5btdD-4oudB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
GLN B 179
ASP B 200
THR B 229
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
GLN  B 179 ( 0.6A)
ASP  B 200 ( 0.6A)
THR  B 229 ( 0.8A)
 1.03A 5hg0A-4oudB:
6.8		 5hg0A-4oudB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 6 ASN B 125
TYR B 127
VAL B 101
VAL B  97
THR B  96
 ASN  B 125 ( 0.6A)
TYR  B 127 ( 1.3A)
VAL  B 101 ( 0.6A)
VAL  B  97 ( 0.6A)
THR  B  96 ( 0.8A)
 1.46A 6f32B-4oudB:
2.9		 6f32B-4oudB:
22.15