SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4our'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		4 / 8 ASP B 271
VAL B 273
HIS B 404
GLY B 269
 None
 0.92A 1ekjA-4ourB:
undetectable
1ekjB-4ourB:
undetectable		 1ekjA-4ourB:
16.15
1ekjB-4ourB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 SER B 134
LEU B 141
PHE B 167
VAL B 190
ALA B 203
 None
 1.20A 1q23H-4ourB:
undetectable
1q23I-4ourB:
undetectable		 1q23H-4ourB:
16.88
1q23I-4ourB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 LEU B 205
LEU B 187
ASN B 188
LEU B 186
LEU B 174
 None
 1.29A 1sqnA-4ourB:
undetectable		 1sqnA-4ourB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 LEU B 205
LEU B 187
ASN B 188
LEU B 186
LEU B 174
 None
 1.30A 2w8yB-4ourB:
undetectable		 2w8yB-4ourB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		4 / 8 ASP B 307
TYR B 276
GLY B 284
PRO B 304
 2VO  B 707 (-3.9A)
2VO  B 707 (-4.1A)
None
None
 0.97A 2ys6A-4ourB:
undetectable		 2ys6A-4ourB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 LEU B 205
LEU B 187
ASN B 188
LEU B 186
LEU B 174
 None
 1.25A 3d90A-4ourB:
undetectable		 3d90A-4ourB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 LEU B 205
LEU B 187
ASN B 188
LEU B 186
LEU B 174
 None
 1.28A 3d90B-4ourB:
undetectable		 3d90B-4ourB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 VAL B 260
VAL B 264
LEU B 267
TYR B 270
ILE B 410
 None
 1.06A 3n8yB-4ourB:
undetectable		 3n8yB-4ourB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		4 / 5 VAL B 264
LEU B 267
TYR B 270
ILE B 410
 None
 0.89A 3n8yB-4ourB:
undetectable		 3n8yB-4ourB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		4 / 6 ILE B 561
GLY B 300
VAL B 286
HIS B 279
 None
 0.98A 4oltB-4ourB:
undetectable		 4oltB-4ourB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 ALA B 203
LEU B 175
SER B 194
PHE B 167
PHE B 128
 None
 0.76A 4rzvA-4ourB:
undetectable		 4rzvA-4ourB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 12 ALA B 203
LEU B 175
SER B 194
PHE B 167
PHE B 128
 None
 0.81A 4rzvB-4ourB:
undetectable		 4rzvB-4ourB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4our PHYTOCHROME B
(Arabidopsis
thaliana) 		5 / 11 ILE B 131
GLY B 211
ASP B 209
ALA B 122
VAL B 334
 None
 1.28A 5hw4B-4ourB:
undetectable		 5hw4B-4ourB:
17.90