SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ov6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 9 ALA B 388
SER B 419
ILE B 416
ILE B 334
THR B 385
 None
None
PG4  B 503 (-4.7A)
None
None
 1.38A 1j3jB-4ov6B:
undetectable		 1j3jB-4ov6B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 LEU B 348
LEU B 351
PHE B 318
ALA B 315
 None
 0.73A 1j8uA-4ov6B:
undetectable		 1j8uA-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.19A 1mj2B-4ov6B:
undetectable		 1mj2B-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.21A 1mj2D-4ov6B:
undetectable		 1mj2D-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.18A 1mjoB-4ov6B:
undetectable		 1mjoB-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.14A 1mjoA-4ov6B:
undetectable		 1mjoA-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.19A 1mjoD-4ov6B:
undetectable		 1mjoD-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU B 283
ALA B 299
ALA B 300
VAL B 285
GLN B 275
 None
 1.28A 1rbpA-4ov6B:
undetectable		 1rbpA-4ov6B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE B 318
ASN B 354
SER B 386
ALA B 322
 None
 1.16A 1rqpC-4ov6B:
2.6		 1rqpC-4ov6B:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE B 318
ASN B 354
SER B 386
ALA B 322
 None
 1.17A 1rqpA-4ov6B:
5.6		 1rqpA-4ov6B:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU B 250
LEU B 230
ALA B 231
SER B 235
THR B 203
 None
 1.08A 2aa5B-4ov6B:
undetectable		 2aa5B-4ov6B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 VAL B 312
VAL B 336
LEU B 286
HIS B 391
 None
 1.01A 2ddwA-4ov6B:
5.9		 2ddwA-4ov6B:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 TYR B 183
ARG B 248
PHE B 270
VAL B 285
 None
 0.94A 2fl5E-4ov6B:
undetectable
2fl5F-4ov6B:
undetectable		 2fl5E-4ov6B:
24.61
2fl5F-4ov6B:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE B 318
ASN B 354
SER B 386
ALA B 322
 None
 1.20A 2v7uA-4ov6B:
5.9		 2v7uA-4ov6B:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 THR B 385
GLY B 337
LEU B 268
PRO B 327
THR B 264
 None
 0.97A 2y7hC-4ov6B:
undetectable		 2y7hC-4ov6B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 6 VAL B 336
LEU B 436
ILE B 395
ILE B 334
 None
 0.89A 3gcsA-4ov6B:
undetectable		 3gcsA-4ov6B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 6 LEU B 406
GLN B 413
LEU B 411
GLU B 410
 None
PG4  B 503 (-3.5A)
None
None
 1.13A 3h5gB-4ov6B:
undetectable
3h5gC-4ov6B:
undetectable		 3h5gB-4ov6B:
6.12
3h5gC-4ov6B:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 0.99A 3keeB-4ov6B:
undetectable		 3keeB-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.93A 3keeB-4ov6B:
undetectable		 3keeB-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 GLN B 433
PHE B 355
TYR B 325
LEU B 440
 None
None
None
PG4  B 503 ( 4.7A)
 1.43A 3keeC-4ov6B:
0.0		 3keeC-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 1.05A 3keeD-4ov6B:
undetectable		 3keeD-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.94A 3keeD-4ov6B:
undetectable		 3keeD-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
 None
 0.86A 3ku1A-4ov6B:
undetectable		 3ku1A-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
 None
 0.85A 3ku1C-4ov6B:
undetectable		 3ku1C-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
 None
 0.81A 3ku1G-4ov6B:
undetectable		 3ku1G-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
 None
 0.84A 3ku1H-4ov6B:
2.3		 3ku1H-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 9 GLY B 394
ALA B 393
ILE B 334
ILE B 368
LEU B 286
 None
 1.02A 3ogpB-4ov6B:
undetectable		 3ogpB-4ov6B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 1.03A 3sudA-4ov6B:
undetectable		 3sudA-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 1.40A 3sueA-4ov6B:
undetectable		 3sueA-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 1.13A 3sueB-4ov6B:
undetectable		 3sueB-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.97A 3sueB-4ov6B:
undetectable		 3sueB-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 1.41A 3sueC-4ov6B:
undetectable		 3sueC-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.95A 3sueD-4ov6B:
undetectable		 3sueD-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 0.95A 3sufA-4ov6B:
undetectable		 3sufA-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.93A 3sufA-4ov6B:
undetectable		 3sufA-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 11 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.94A 3sufC-4ov6B:
undetectable		 3sufC-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 0.82A 3sufD-4ov6B:
undetectable		 3sufD-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 HIS B 193
GLN B 190
SER B 191
VAL B 200
 None
 1.24A 4a99D-4ov6B:
2.8		 4a99D-4ov6B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 ALA B 305
ALA B 300
ALA B 330
PRO B 331
 None
 0.87A 4du2B-4ov6B:
undetectable		 4du2B-4ov6B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU B 415
ALA B 393
ALA B 388
GLY B 365
ALA B 442
 None
 1.11A 4enhA-4ov6B:
undetectable		 4enhA-4ov6B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 ALA B 363
THR B 339
VAL B 423
ILE B 424
 None
 0.94A 4xe3A-4ov6B:
undetectable		 4xe3A-4ov6B:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU B 230
VAL B 233
LEU B 415
VAL B 312
VAL B 310
 None
 0.92A 4y0pA-4ov6B:
undetectable		 4y0pA-4ov6B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR B 437
GLY B 337
ALA B 322
THR B 353
 None
 0.96A 5eevL-4ov6B:
undetectable
5eevV-4ov6B:
undetectable		 5eevL-4ov6B:
14.07
5eevV-4ov6B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR B 437
GLY B 337
ALA B 322
THR B 353
 None
 0.96A 5eewL-4ov6B:
undetectable
5eewV-4ov6B:
undetectable		 5eewL-4ov6B:
14.07
5eewV-4ov6B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR B 437
GLY B 337
ALA B 322
THR B 353
 None
 0.95A 5ef3L-4ov6B:
undetectable
5ef3V-4ov6B:
undetectable		 5ef3L-4ov6B:
14.07
5ef3V-4ov6B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
ADNECTIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASP B 238
ARG B 194
LYS F  -1
HIS F  85
GLY B 370
 None
 1.35A 5k7uA-4ov6B:
undetectable		 5k7uA-4ov6B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 HIS B 417
SER B 419
LYS B 421
 None
 0.99A 5os7A-4ov6B:
undetectable		 5os7A-4ov6B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 VAL B 333
THR B 335
LEU B 268
VAL B 252
 None
 0.94A 6bqgA-4ov6B:
undetectable		 6bqgA-4ov6B:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 1.21A 6c2mC-4ov6B:
undetectable		 6c2mC-4ov6B:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 9 VAL B 234
HIS B 391
GLY B 394
ILE B 271
ASP B 186
 None
 1.27A 6c2mC-4ov6B:
undetectable		 6c2mC-4ov6B:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 6 TYR B 183
VAL B 200
VAL B 202
THR B 203
 None
 1.45A 6f32B-4ov6B:
undetectable		 6f32B-4ov6B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 HIS B 417
SER B 419
LYS B 421
 None
 0.99A 6gmdB-4ov6B:
undetectable		 6gmdB-4ov6B:
21.00