SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ova'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		5 / 11 TYR A 161
LEU A 168
ILE A 185
GLU A 135
LEU A 192
 None
 1.31A 1mrqA-4ovaA:
undetectable		 1mrqA-4ovaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		3 / 3 PRO A  76
GLU A   7
TYR A  16
 None
 0.79A 2zmbA-4ovaA:
undetectable		 2zmbA-4ovaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		3 / 3 ALA A 153
ARG A 180
LYS A 179
 None
 1.04A 3kp5B-4ovaA:
undetectable		 3kp5B-4ovaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		5 / 9 ASN A  12
GLY A  13
GLY A  10
ARG A   9
PHE A  15
 None
 1.42A 4h2gA-4ovaA:
undetectable		 4h2gA-4ovaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		4 / 6 LYS A 130
LEU A 171
SER A 158
THR A 160
 None
 0.86A 4ikiB-4ovaA:
undetectable		 4ikiB-4ovaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens) 		4 / 5 HIS A 188
MET A 140
VAL A 133
LEU A 137
 None
 1.49A 5xdhB-4ovaA:
undetectable		 5xdhB-4ovaA:
20.36