SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ovb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LIN_A_TFPA154_1 (CALMODULIN)	4ovb	PROTEIN OSA (Shigella flexneri)	4 / 7	LEU A 91 GLU A 12 LEU A 16 GLU A 19	None	0.98A	1linA-4ovbA: undetectable	1linA-4ovbA: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1868_0 (FPRA)	4ovb	PROTEIN OSA (Shigella flexneri)	3 / 3	ALA A 106 HIS A 107 VAL A 110	None AUC A 203 (-3.7A) None	0.25A	1lqtB-4ovbA: undetectable	1lqtB-4ovbA: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1425_0 (FPRA)	4ovb	PROTEIN OSA (Shigella flexneri)	3 / 3	ALA A 106 HIS A 107 VAL A 110	None AUC A 203 (-3.7A) None	0.25A	1lquB-4ovbA: undetectable	1lquB-4ovbA: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 12	TYR A 68 GLY A 170 ASN A 70 VAL A 132 PHE A 134	AUC A 206 (-3.2A) None None None None	1.24A	2zznA-4ovbA: undetectable	2zznA-4ovbA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_J_CLMJ221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 12	PHE A 134 LEU A 165 VAL A 169 PHE A 74 VAL A 121	None	1.27A	3u9fJ-4ovbA: undetectable 3u9fK-4ovbA: undetectable	3u9fJ-4ovbA: 21.24 3u9fK-4ovbA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_R_CLMR221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 10	PHE A 134 LEU A 165 VAL A 169 PHE A 74 VAL A 121	None	1.30A	3u9fR-4ovbA: undetectable	3u9fR-4ovbA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RS0_A_IBPA706_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 9	VAL A 154 LEU A 155 SER A 156 LEU A 165 GLY A 137	None None None None PO4 A 201 (-3.1A)	1.10A	4rs0A-4ovbA: undetectable	4rs0A-4ovbA: 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_A_SAMA601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 12	GLY A 71 LEU A 144 SER A 141 VAL A 69 VAL A 154	None	1.12A	5dpdA-4ovbA: undetectable	5dpdA-4ovbA: 16.04

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LIN_A_TFPA154_1","CALMODULIN","4ovb","PROTEIN OSA","Shigella flexneri",4,"LEU A  91;GLU A  12;LEU A  16;GLU A  19","None","0.98A","1linA-4ovbA:undetectable","1linA-4ovbA:19.31"],["1LQT_B_ACTB1868_0","FPRA","4ovb","PROTEIN OSA","Shigella flexneri",3,"ALA A 106;HIS A 107;VAL A 110","None;AUC A 203 (-3.7A);None","0.25A","1lqtB-4ovbA:undetectable","1lqtB-4ovbA:16.26"],["1LQU_B_ACTB1425_0","FPRA","4ovb","PROTEIN OSA","Shigella flexneri",3,"ALA A 106;HIS A 107;VAL A 110","None;AUC A 203 (-3.7A);None","0.25A","1lquB-4ovbA:undetectable","1lquB-4ovbA:16.26"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","4ovb","PROTEIN OSA","Shigella flexneri",5,"TYR A  68;GLY A 170;ASN A  70;VAL A 132;PHE A 134","AUC A 206 (-3.2A);None;None;None;None","1.24A","2zznA-4ovbA:undetectable","2zznA-4ovbA:18.58"],["3U9F_J_CLMJ221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","4ovb","PROTEIN OSA","Shigella flexneri",5,"PHE A 134;LEU A 165;VAL A 169;PHE A  74;VAL A 121","None","1.27A","3u9fJ-4ovbA:undetectable;3u9fK-4ovbA:undetectable","3u9fJ-4ovbA:21.24;3u9fK-4ovbA:21.24"],["3U9F_R_CLMR221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","4ovb","PROTEIN OSA","Shigella flexneri",5,"PHE A 134;LEU A 165;VAL A 169;PHE A  74;VAL A 121","None","1.30A","3u9fR-4ovbA:undetectable","3u9fR-4ovbA:21.24"],["4RS0_A_IBPA706_1","PROSTAGLANDIN G\/H SYNTHASE 2","4ovb","PROTEIN OSA","Shigella flexneri",5,"VAL A 154;LEU A 155;SER A 156;LEU A 165;GLY A 137","None;None;None;None;PO4 A 201 (-3.1A)","1.10A","4rs0A-4ovbA:undetectable","4rs0A-4ovbA:13.96"],["5DPD_A_SAMA601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","4ovb","PROTEIN OSA","Shigella flexneri",5,"GLY A  71;LEU A 144;SER A 141;VAL A  69;VAL A 154","None","1.12A","5dpdA-4ovbA:undetectable","5dpdA-4ovbA:16.04"]]