SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ovk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.11A 1dyiA-4ovkA:
undetectable		 1dyiA-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.08A 1dyiB-4ovkA:
undetectable		 1dyiB-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 11 SER A 221
VAL A 222
SER A 262
PHE A 264
MET A 317
 None
 1.48A 1fdtA-4ovkA:
1.8		 1fdtA-4ovkA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.04A 1jolA-4ovkA:
undetectable		 1jolA-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.10A 1jolB-4ovkA:
undetectable		 1jolB-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 LEU A 143
VAL A  73
ILE A  61
ARG A 166
 None
 0.93A 1opjB-4ovkA:
undetectable		 1opjB-4ovkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 8 MET A 317
ALA A 296
ILE A 260
ASN A 263
 None
 1.14A 1pnlA-4ovkA:
undetectable
1pnlB-4ovkA:
undetectable		 1pnlA-4ovkA:
19.94
1pnlB-4ovkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.13A 1tdrA-4ovkA:
undetectable		 1tdrA-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 4 PHE A 110
ASP A 112
PHE A 115
VAL A  62
 None
 1.48A 1w0fA-4ovkA:
undetectable		 1w0fA-4ovkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 5 GLY A 318
PRO A 297
ALA A 296
ILE A 260
 None
 0.82A 2aofA-4ovkA:
undetectable		 2aofA-4ovkA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 SER A  94
TYR A 339
ILE A 300
TRP A 303
 None
 1.15A 2x45B-4ovkA:
undetectable		 2x45B-4ovkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 SER A  94
TYR A 339
ILE A 300
TRP A 303
 None
 1.14A 2x45C-4ovkA:
undetectable		 2x45C-4ovkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 PRO A  85
SER A 108
LYS A  88
GLU A  92
 None
 1.46A 2x7hA-4ovkA:
undetectable		 2x7hA-4ovkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 GLN A 177
ILE A  69
TYR A 343
TYR A  71
 None
 1.28A 2xz5D-4ovkA:
undetectable
2xz5E-4ovkA:
undetectable		 2xz5D-4ovkA:
24.18
2xz5E-4ovkA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 SER A  94
TYR A 339
ILE A 300
TRP A 303
 None
 1.05A 3bu1A-4ovkA:
undetectable		 3bu1A-4ovkA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		6 / 12 ALA A 178
GLN A 177
LEU A 181
LEU A 172
VAL A 151
ILE A 153
 None
 1.40A 3h0aA-4ovkA:
undetectable		 3h0aA-4ovkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.22A 3ia4D-4ovkA:
undetectable		 3ia4D-4ovkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.08A 3ql0A-4ovkA:
undetectable		 3ql0A-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		6 / 12 LEU A 320
MET A 317
ILE A 258
ALA A 287
PRO A 269
ILE A 360
 None
 1.50A 3vrmA-4ovkA:
undetectable		 3vrmA-4ovkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.13A 4ej1B-4ovkA:
undetectable		 4ej1B-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.11A 4kjkA-4ovkA:
undetectable		 4kjkA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.06A 4psyA-4ovkA:
undetectable		 4psyA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.09A 4qleA-4ovkA:
undetectable		 4qleA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 11 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.18A 4qlfA-4ovkA:
undetectable		 4qlfA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.12A 4qlgA-4ovkA:
undetectable		 4qlgA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.09A 4qlgB-4ovkA:
undetectable		 4qlgB-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.10A 4rgcA-4ovkA:
undetectable		 4rgcA-4ovkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.08A 4x5fA-4ovkA:
undetectable		 4x5fA-4ovkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.04A 4x5gA-4ovkA:
undetectable		 4x5gA-4ovkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.12A 4x5hA-4ovkA:
undetectable		 4x5hA-4ovkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 4 VAL A 216
ALA A 217
ASN A 223
GLN A 224
 None
 1.34A 4zgfA-4ovkA:
undetectable		 4zgfA-4ovkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 LEU A 347
ARG A 332
PHE A 342
TYR A 184
TYR A 345
 None
None
None
PGE  A 401 (-3.6A)
None
 1.37A 5czyA-4ovkA:
undetectable		 5czyA-4ovkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.08A 5e8qB-4ovkA:
undetectable		 5e8qB-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.07A 5eajB-4ovkA:
undetectable		 5eajB-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 TYR A 343
TYR A 339
GLN A 177
HIS A 185
 None
 1.40A 5ov9B-4ovkA:
undetectable		 5ov9B-4ovkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 300
PHE A  96
LYS A  97
ILE A  83
LEU A 103
 None
 1.05A 5ujxB-4ovkA:
undetectable		 5ujxB-4ovkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 TYR A  71
ASP A  74
ASP A  77
 None
 0.84A 5x6yA-4ovkA:
undetectable		 5x6yA-4ovkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 5 LEU A 331
TYR A 329
MET A 314
GLY A 318
 None
 1.03A 6hd6A-4ovkA:
undetectable		 6hd6A-4ovkA:
14.19