SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ovq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		4 / 8 LYS A  53
GLY A  55
ASP A  25
TYR A  58
 None
 1.00A 2aouA-4ovqA:
undetectable		 2aouA-4ovqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 11 TYR A 308
PHE A 309
ILE A 108
LEU A 105
ILE A 126
 None
 1.17A 2dg9A-4ovqA:
undetectable		 2dg9A-4ovqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		4 / 8 ALA A 180
GLY A 177
THR A 176
GLU A 173
 None
 0.92A 3rglA-4ovqA:
undetectable		 3rglA-4ovqA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 PHE A  88
CYH A 236
ILE A 136
MET A 131
VAL A  78
 None
 1.43A 3sp6A-4ovqA:
undetectable		 3sp6A-4ovqA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		4 / 7 CYH A 236
ILE A 237
PRO A 138
ILE A 136
 None
 1.09A 4w5oA-4ovqA:
undetectable		 4w5oA-4ovqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		4 / 7 GLY A  94
TYR A 308
SER A 104
ASN A 172
 None
 1.12A 4ws0A-4ovqA:
undetectable		 4ws0A-4ovqA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 PRO A  92
GLY A  86
MET A 131
GLU A 235
LEU A  90
 None
None
None
BDP  A 402 (-3.0A)
None
 1.30A 5emlA-4ovqA:
undetectable		 5emlA-4ovqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		3 / 3 LEU A  60
ILE A  85
TYR A 142
 None
 0.69A 5uunB-4ovqA:
undetectable		 5uunB-4ovqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLU A  84
ASN A 240
GLY A  81
GLY A  29
ILE A  85
 None
 1.16A 5vooB-4ovqA:
undetectable		 5vooB-4ovqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLU A  84
ASN A 240
GLY A  81
GLY A  29
ILE A  85
 None
 1.17A 5vooD-4ovqA:
undetectable		 5vooD-4ovqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLU A  84
ASN A 240
GLY A  81
GLY A  29
ILE A  85
 None
 1.17A 5vooF-4ovqA:
undetectable		 5vooF-4ovqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLU A  84
ASN A 240
GLY A  81
GLY A  29
ILE A  85
 None
 1.13A 5vopB-4ovqA:
undetectable		 5vopB-4ovqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLY A 184
GLY A 183
LEU A 182
HIS A 230
PRO A  92
 None
 1.04A 6gngB-4ovqA:
undetectable		 6gngB-4ovqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLY A  86
CYH A 238
LEU A  90
ILE A  75
MET A 131
 None
 1.50A 6md4A-4ovqA:
undetectable		 6md4A-4ovqA:
14.17