SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ovs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 7 PHE A 190
ARG A 167
TYR A 234
SER A  88
 SIN  A 401 (-2.5A)
SIN  A 401 (-3.0A)
SIN  A 401 (-4.4A)
SIN  A 401 ( 3.5A)
 1.30A 1gyxA-4ovsA:
2.1
1gyxB-4ovsA:
2.0		 1gyxA-4ovsA:
14.16
1gyxB-4ovsA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		3 / 3 TRP A 141
LEU A 235
LYS A 127
 None
 1.33A 1yajK-4ovsA:
undetectable		 1yajK-4ovsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		5 / 10 GLY A 233
SER A  88
SER A  90
PHE A  89
LEU A 101
 None
SIN  A 401 ( 3.5A)
None
None
None
 1.44A 2c2bA-4ovsA:
0.0
2c2bB-4ovsA:
0.0		 2c2bA-4ovsA:
20.92
2c2bB-4ovsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_D_SAMD500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		5 / 9 LEU A 101
GLY A 233
SER A  88
SER A  90
PHE A  89
 None
None
SIN  A 401 ( 3.5A)
None
None
 1.43A 2c2bC-4ovsA:
0.0
2c2bD-4ovsA:
0.0		 2c2bC-4ovsA:
20.92
2c2bD-4ovsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		5 / 11 GLY A 233
SER A  88
SER A  90
PHE A  89
LEU A 101
 None
SIN  A 401 ( 3.5A)
None
None
None
 1.42A 2c2bE-4ovsA:
undetectable
2c2bF-4ovsA:
2.3		 2c2bE-4ovsA:
20.92
2c2bF-4ovsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 8 VAL A 220
VAL A 201
TYR A 194
GLN A 221
 None
 1.00A 3remA-4ovsA:
undetectable		 3remA-4ovsA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 8 VAL A 220
VAL A 201
TYR A 194
GLN A 221
 None
 0.99A 3remB-4ovsA:
undetectable		 3remB-4ovsA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 5 ILE A  84
ALA A 257
MET A 238
PHE A  45
 None
 0.96A 4dc3B-4ovsA:
2.1		 4dc3B-4ovsA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 6 ARG A 167
GLY A 204
GLN A 177
MET A 307
 SIN  A 401 (-3.0A)
None
None
None
 0.86A 4g0vB-4ovsA:
undetectable		 4g0vB-4ovsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 6 ALA A 161
ILE A 168
SER A 227
ILE A 155
 None
 0.82A 4r21A-4ovsA:
undetectable		 4r21A-4ovsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		5 / 12 LEU A 232
ALA A 205
SER A 149
LEU A 209
PHE A 190
 SIN  A 401 ( 4.3A)
None
None
None
SIN  A 401 (-2.5A)
 1.33A 4udaA-4ovsA:
undetectable		 4udaA-4ovsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		3 / 3 HIS A  30
SER A  88
ASN A 211
 None
SIN  A 401 ( 3.5A)
SIN  A 401 (-3.3A)
 0.90A 5cprB-4ovsA:
undetectable		 5cprB-4ovsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		5 / 10 VAL A 236
ILE A  26
VAL A 254
PHE A  45
ALA A 261
 None
 1.19A 5nukA-4ovsA:
undetectable		 5nukA-4ovsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 6 GLU A 265
LYS A 267
GLU A 263
ALA A 261
 None
 1.06A 6an0A-4ovsA:
undetectable		 6an0A-4ovsA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Sulfurospirillum
deleyianum) 		4 / 4 VAL A 236
ALA A  85
PHE A  92
PHE A 135
 None
 1.44A 6cbdA-4ovsA:
undetectable		 6cbdA-4ovsA:
17.84