SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ow8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  78
ASP A  32
ASN A  33
GLU A  81
 None
 1.27A 1rjdA-4ow8A:
undetectable		 1rjdA-4ow8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  78
ASP A  32
ASN A  33
GLU A  81
 None
 1.26A 1rjdB-4ow8A:
undetectable		 1rjdB-4ow8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 265
PHE A 267
SER A 263
ARG A 127
 None
 1.39A 2a3cA-4ow8A:
undetectable		 2a3cA-4ow8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
LEU A 241
PHE A 267
ALA A 118
 None
 0.98A 2aylA-4ow8A:
undetectable		 2aylA-4ow8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
PHE A 267
ALA A 118
LEU A 115
 None
 1.10A 2aylA-4ow8A:
undetectable		 2aylA-4ow8A:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  27
ALA A  40
MET A  95
VAL A  98
ASN A 146
ASP A 159
 None
 0.60A 2fumC-4ow8A:
31.8		 2fumC-4ow8A:
41.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 117
SER A 114
LEU A 122
GLY A 207
VAL A 271
ALA A 270
 SO4  A 302 (-4.2A)
SO4  A 302 (-2.9A)
None
None
None
None
 1.41A 2kceB-4ow8A:
undetectable		 2kceB-4ow8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A 148
THR A 158
ASP A 159
PHE A 160
 None
 1.15A 3bbtD-4ow8A:
24.4		 3bbtD-4ow8A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
LEU A 241
PHE A 267
ALA A 118
 None
 0.98A 3kk6A-4ow8A:
undetectable		 3kk6A-4ow8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  44
GLY A  25
PHE A  48
PHE A  54
 None
 1.11A 3smtA-4ow8A:
undetectable		 3smtA-4ow8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  19
GLY A  22
GLY A  25
VAL A  27
ALA A  40
LYS A  42
ASP A 159
 None
 0.80A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  19
GLY A  25
VAL A  27
ALA A  40
LEU A  44
ASP A 159
 None
 0.84A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 147
LEU A 115
ILE A 249
VAL A 245
LEU A 248
 None
 1.09A 3w67B-4ow8A:
undetectable		 3w67B-4ow8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		8 / 12 LYS A  42
MET A  95
ASP A 141
LYS A 143
ASN A 146
ASP A 159
GLY A 161
GLY A 179
 None
 1.05A 4an2A-4ow8A:
25.0		 4an2A-4ow8A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 139
LEU A 122
LEU A 103
ASP A 120
 None
 1.33A 4aqlA-4ow8A:
undetectable		 4aqlA-4ow8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 126
GLY A 265
PRO A 266
LEU A 203
VAL A 142
 None
 0.99A 4gc9A-4ow8A:
undetectable		 4gc9A-4ow8A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 LYS A  42
MET A  95
ASN A 146
ASP A 159
GLY A 161
 None
 0.90A 4lmnA-4ow8A:
24.7		 4lmnA-4ow8A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  27
ALA A  40
LYS A  42
LEU A 148
 None
 0.67A 4o0uA-4ow8A:
9.7		 4o0uA-4ow8A:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  19
ALA A  40
LYS A  42
LEU A  97
VAL A  98
LEU A 148
 None
 0.63A 4rz7A-4ow8A:
9.2		 4rz7A-4ow8A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  19
ALA A  40
THR A  65
LEU A  97
VAL A  98
LEU A 148
 None
 0.63A 4rz7A-4ow8A:
9.2		 4rz7A-4ow8A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.03A 5kf8A-4ow8A:
undetectable		 5kf8A-4ow8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.00A 5kgpA-4ow8A:
undetectable		 5kgpA-4ow8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 0.97A 5kgpB-4ow8A:
undetectable		 5kgpB-4ow8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  57
ILE A 162
PHE A  58
 None
 0.76A 5kirA-4ow8A:
undetectable		 5kirA-4ow8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  93
THR A 158
ASP A 159
 None
 0.83A 5yu9B-4ow8A:
23.7		 5yu9B-4ow8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  93
THR A 158
ASP A 159
 None
 0.82A 5yu9C-4ow8A:
23.6		 5yu9C-4ow8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 261
ALA A 273
LEU A 248
 None
 0.76A 6d9kF-4ow8A:
undetectable		 6d9kF-4ow8A:
17.89