SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4owr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4owr MRNA EXPORT FACTOR
(Homo
sapiens) 		5 / 12 PHE A 330
LEU A  45
ALA A 331
LEU A 355
ILE A 318
 None
 1.07A 1crbA-4owrA:
undetectable		 1crbA-4owrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4owr MRNA EXPORT FACTOR
(Homo
sapiens) 		3 / 3 PRO A 250
ASN A 254
HIS A 243
 None
 0.93A 4ma3H-4owrA:
undetectable
4ma3L-4owrA:
undetectable		 4ma3H-4owrA:
20.23
4ma3L-4owrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4owr MRNA EXPORT FACTOR
(Homo
sapiens) 		3 / 3 VAL A 101
GLN A  82
CYH A  68
 None
 0.82A 5icxC-4owrA:
undetectable
5icxF-4owrA:
undetectable		 5icxC-4owrA:
23.58
5icxF-4owrA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4owr MRNA EXPORT FACTOR
(Homo
sapiens) 		4 / 6 THR A 229
GLY A 230
PHE A 231
ILE A 279
 None
 0.80A 5kmfA-4owrA:
undetectable
5kmfC-4owrA:
undetectable		 5kmfA-4owrA:
21.65
5kmfC-4owrA:
21.65