SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4owt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 5 GLY A 376
LEU A 379
THR A 380
VAL A 418
 None
 0.99A 1ekjF-4owtA:
undetectable
1ekjG-4owtA:
undetectable		 1ekjF-4owtA:
18.95
1ekjG-4owtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 6 PHE A 235
ILE A 216
ALA A 208
MET A 168
 None
 1.23A 1hk2A-4owtA:
undetectable		 1hk2A-4owtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 8 HIS A 219
TYR A 212
LEU A 225
LEU A 215
 None
 1.12A 1i7zA-4owtA:
undetectable		 1i7zA-4owtA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 4 LEU A 433
ILE A 375
ILE A 350
ALA A 391
 None
 0.85A 2i30A-4owtA:
3.0		 2i30A-4owtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 CYH A 354
LEU A 395
VAL A 418
LEU A 305
LEU A 301
 None
 1.49A 2prgB-4owtA:
undetectable		 2prgB-4owtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens) 		5 / 12 LEU A 305
VAL A 217
SER C  79
SER C  80
ASN A 390
 None
 1.49A 2y00A-4owtA:
undetectable		 2y00A-4owtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens) 		5 / 12 LEU A 305
VAL A 217
SER C  79
SER C  80
ASN A 390
 None
 1.44A 2y00B-4owtA:
undetectable		 2y00B-4owtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens) 		5 / 12 LEU A 305
VAL A 217
SER C  79
SER C  80
ASN A 390
 None
 1.45A 2y01B-4owtA:
undetectable		 2y01B-4owtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ARG A 263
TYR C  82
LEU C 101
ASN A 260
VAL A 233
 None
 1.09A 2zzmA-4owtA:
undetectable		 2zzmA-4owtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ARG A 263
TYR C  82
LEU C 101
ASN A 260
VAL A 233
 None
 1.07A 2zznA-4owtA:
undetectable		 2zznA-4owtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		3 / 3 ARG A  54
THR A  63
THR A  99
 None
 0.70A 3k2hB-4owtA:
undetectable		 3k2hB-4owtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		3 / 3 GLN A 144
THR A  99
LEU A 111
 None
 0.61A 3ondA-4owtA:
undetectable		 3ondA-4owtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		3 / 3 GLN A 144
THR A  99
LEU A 111
 None
 0.61A 3ondB-4owtA:
undetectable		 3ondB-4owtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.91A 3uboB-4owtA:
undetectable		 3uboB-4owtA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.90A 4e3aA-4owtA:
undetectable		 4e3aA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 7 SER A 155
TYR A 108
MET A 119
LEU A 123
 None
 1.20A 4hxyB-4owtA:
undetectable		 4hxyB-4owtA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 TYR A 336
PHE A 332
LEU A 305
LEU A 349
LEU A 135
 None
 1.28A 4j03A-4owtA:
undetectable		 4j03A-4owtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.88A 4jkuB-4owtA:
undetectable		 4jkuB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.88A 4k8pA-4owtA:
undetectable		 4k8pA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.88A 4k8pB-4owtA:
undetectable		 4k8pB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.88A 4k8tA-4owtA:
undetectable		 4k8tA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4k8tB-4owtA:
undetectable		 4k8tB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4k9cA-4owtA:
undetectable		 4k9cA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4k9cB-4owtA:
undetectable		 4k9cB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4k9iA-4owtA:
undetectable		 4k9iA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4k9iB-4owtA:
undetectable		 4k9iB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4kadA-4owtA:
undetectable		 4kadA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4kadB-4owtA:
undetectable		 4kadB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4lbxA-4owtA:
undetectable		 4lbxA-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4lbxB-4owtA:
undetectable		 4lbxB-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.89A 4lc4A-4owtA:
undetectable		 4lc4A-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP A 218
GLY A 174
GLY A 173
LEU A 183
ASP A 348
 None
 0.87A 4lc4B-4owtA:
undetectable		 4lc4B-4owtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 MET A 419
ALA A 415
PHE A 436
THR A 432
ASN A 443
 None
 1.47A 4z7fA-4owtA:
undetectable		 4z7fA-4owtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ILE A 129
LEU A 123
VAL A 146
VAL A 149
PHE A  94
 None
 1.29A 5bykA-4owtA:
undetectable		 5bykA-4owtA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 THR A 306
LYS A 169
GLY A 173
THR A 211
SER A 342
 None
 1.23A 5hfjG-4owtA:
undetectable		 5hfjG-4owtA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 VAL A 149
ALA A 112
VAL A 157
GLY A 159
ALA A 160
 None
 1.06A 5kirA-4owtA:
undetectable		 5kirA-4owtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		5 / 12 VAL A 149
ALA A 112
VAL A 157
GLY A 159
ALA A 160
 None
 1.09A 5kirB-4owtA:
1.3		 5kirB-4owtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 213
SER C  79
HIS C  76
GLU A 268
PHE A 267
 None
 1.12A 5l6eA-4owtA:
undetectable		 5l6eA-4owtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 5 ASP A 117
ILE A 126
PHE A  94
ASN A  76
 None
 1.20A 6a93B-4owtA:
undetectable		 6a93B-4owtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 7 ASP A 348
ARG A 304
CYH A 236
GLU A 232
 None
 1.29A 6mn5B-4owtA:
undetectable		 6mn5B-4owtA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens) 		4 / 6 ASP A 348
ARG A 304
CYH A 236
GLU A 232
 None
 1.32A 6mn5D-4owtA:
undetectable		 6mn5D-4owtA:
9.01