SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ox2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 VAL A 456
GLY A 457
ILE A 608
ALA A 459
ILE A 592
 None
 1.10A 1cetA-4ox2A:
2.0		 1cetA-4ox2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 TRP A 260
GLY A 259
GLU A 258
GLU A 257
GLU A 188
 None
 1.38A 1gahA-4ox2A:
undetectable		 1gahA-4ox2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 ALA A 281
VAL A 308
GLY A 269
ILE A 270
ILE A 428
 None
 0.73A 1hshB-4ox2A:
undetectable		 1hshB-4ox2A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 ILE A 156
SER A 179
ALA A 183
LEU A 184
ARG A 171
 None
 1.19A 1i9gA-4ox2A:
undetectable		 1i9gA-4ox2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 11 SER A 239
GLY A 234
TYR A 165
GLY A 237
HIS A 401
 None
None
None
SPV  A 704 (-3.6A)
None
 1.13A 1iolA-4ox2A:
undetectable		 1iolA-4ox2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 PHE A 126
LEU A  37
MET A 134
 None
 0.74A 1mx1D-4ox2A:
undetectable		 1mx1D-4ox2A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 TYR A 445
GLY A 434
PHE A 284
LEU A 266
ASN A 515
 None
 1.26A 1nw3A-4ox2A:
undetectable		 1nw3A-4ox2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 ALA A 439
VAL A 441
TRP A 585
 None
 0.88A 1w5uC-4ox2A:
undetectable
1w5uD-4ox2A:
undetectable		 1w5uC-4ox2A:
9.16
1w5uD-4ox2A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 GLY A 531
GLU A 532
ASN A 297
 None
 0.70A 1zq9A-4ox2A:
undetectable		 1zq9A-4ox2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 ALA A 347
THR A 339
PHE A 332
 None
 0.59A 2c6nB-4ox2A:
undetectable		 2c6nB-4ox2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 PHE A 485
ARG A 483
ARG A  87
ASP A 478
 None
None
SPV  A 704 (-3.8A)
None
 1.15A 2e5dA-4ox2A:
undetectable
2e5dB-4ox2A:
undetectable		 2e5dA-4ox2A:
22.98
2e5dB-4ox2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 ASP A 478
PHE A 485
ARG A 483
ARG A  87
 None
None
None
SPV  A 704 (-3.8A)
 1.10A 2e5dA-4ox2A:
undetectable
2e5dB-4ox2A:
undetectable		 2e5dA-4ox2A:
22.98
2e5dB-4ox2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 4 LEU A 218
THR A 217
ILE A  94
HIS A 221
 None
 1.26A 2jfaB-4ox2A:
undetectable		 2jfaB-4ox2A:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 8 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.33A 2rk8A-4ox2A:
61.0		 2rk8A-4ox2A:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 7 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.36A 2rk8B-4ox2A:
61.9		 2rk8B-4ox2A:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 ALA A 281
VAL A 308
GLY A 269
ILE A 270
ILE A 428
 None
 0.90A 2rkgB-4ox2A:
undetectable		 2rkgB-4ox2A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 11 ALA A  78
GLY A 234
ILE A 356
VAL A 166
SER A 169
 None
 1.13A 3gyqB-4ox2A:
undetectable		 3gyqB-4ox2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 ALA A 439
VAL A 441
TRP A 585
 None
 0.81A 3l8lC-4ox2A:
undetectable
3l8lD-4ox2A:
undetectable		 3l8lC-4ox2A:
9.16
3l8lD-4ox2A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 PHE A 231
SER A 195
THR A 161
ALA A 211
LEU A 206
 None
 1.28A 3lcvB-4ox2A:
undetectable		 3lcvB-4ox2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 ALA A 459
GLY A 434
GLY A 435
VAL A 600
LEU A 596
 None
 1.07A 3m6wA-4ox2A:
undetectable		 3m6wA-4ox2A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 10 ALA A 281
VAL A 308
GLY A 269
ILE A 270
ILE A 428
 None
 0.85A 3s43B-4ox2A:
undetectable		 3s43B-4ox2A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 LEU A 323
GLU A 263
ALA A 283
HIS A 496
SER A 499
 None
 1.23A 4aqlA-4ox2A:
undetectable		 4aqlA-4ox2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 TYR A 235
GLY A 236
PHE A 333
ASP A 311
ARG A 483
 None
SPV  A 704 ( 3.8A)
SPV  A 704 (-4.9A)
MN  A 701 (-2.5A)
None
 1.36A 4gcpA-4ox2A:
0.0		 4gcpA-4ox2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 TYR A 235
GLY A 236
PHE A 333
ASP A 311
ARG A 483
 None
SPV  A 704 ( 3.8A)
SPV  A 704 (-4.9A)
MN  A 701 (-2.5A)
None
 1.36A 4gcpB-4ox2A:
0.0		 4gcpB-4ox2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 LEU A 300
VAL A 305
ILE A 270
LEU A 280
GLY A 542
 None
 0.98A 4kukA-4ox2A:
undetectable		 4kukA-4ox2A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 ILE A 428
MET A 500
ARG A 503
 None
 0.95A 4lnwA-4ox2A:
undetectable		 4lnwA-4ox2A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_G_FOLG301_0
(FOLATE RECEPTOR
ALPHA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 TYR A 235
ARG A 405
LYS A 243
GLY A 242
SER A 286
 None
GTP  A 703 ( 2.8A)
SPV  A 704 (-4.5A)
None
SPV  A 704 ( 2.8A)
 1.09A 4lrhG-4ox2A:
0.0		 4lrhG-4ox2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 5 LEU A 184
GLY A 185
ILE A 158
LYS A 191
 None
 1.21A 4ma8C-4ox2A:
1.9		 4ma8C-4ox2A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.42A 4ojbA-4ox2A:
undetectable		 4ojbA-4ox2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.41A 4okbA-4ox2A:
undetectable		 4okbA-4ox2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.46A 4okxA-4ox2A:
undetectable		 4okxA-4ox2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 LYS A 244
LYS A 290
ALA A 481
 MN  A 701 ( 2.4A)
GTP  A 703 (-2.6A)
None
 1.47A 4ot2A-4ox2A:
2.9		 4ot2A-4ox2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 5 ARG A  87
ARG A 115
GLY A 114
SER A 286
 SPV  A 704 (-3.8A)
None
None
SPV  A 704 ( 2.8A)
 1.15A 4z3oA-4ox2A:
undetectable
4z3oB-4ox2A:
undetectable		 4z3oA-4ox2A:
23.65
4z3oB-4ox2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 4 ARG A 610
HIS A 502
ALA A 501
GLU A 607
 None
 1.10A 5a06A-4ox2A:
undetectable
5a06F-4ox2A:
undetectable		 5a06A-4ox2A:
21.87
5a06F-4ox2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 5 SER A 286
ARG A 115
GLY A 114
ARG A  87
 SPV  A 704 ( 2.8A)
None
None
SPV  A 704 (-3.8A)
 1.15A 5cdqA-4ox2A:
2.9
5cdqB-4ox2A:
undetectable
5cdqC-4ox2A:
2.8		 5cdqA-4ox2A:
21.19
5cdqB-4ox2A:
16.29
5cdqC-4ox2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 ALA A 281
VAL A 308
GLY A 269
ILE A 270
ILE A 428
 None
 0.83A 5e5jA-4ox2A:
undetectable		 5e5jA-4ox2A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 6 GLU A  26
PHE A 189
GLU A  32
VAL A  31
 None
 1.41A 5h4dA-4ox2A:
undetectable		 5h4dA-4ox2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 ASP A 310
GLY A 334
HIS A 264
ASP A 311
 MN  A 702 (-4.2A)
MN  A 702 ( 4.3A)
MN  A 701 (-3.4A)
MN  A 701 (-2.5A)
 0.98A 5nnwD-4ox2A:
undetectable		 5nnwD-4ox2A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 ASP A 310
GLY A 334
HIS A 264
ASP A 311
 MN  A 702 (-4.2A)
MN  A 702 ( 4.3A)
MN  A 701 (-3.4A)
MN  A 701 (-2.5A)
 0.96A 5no9D-4ox2A:
undetectable		 5no9D-4ox2A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 ALA A 281
VAL A 308
GLY A 269
ILE A 270
ILE A 428
 None
 0.86A 5t8hA-4ox2A:
undetectable		 5t8hA-4ox2A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 ILE A 416
ASN A 330
CYH A 407
 None
 0.81A 6bp4A-4ox2A:
undetectable		 6bp4A-4ox2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 TYR A 595
ASP A 598
GLN A 599
 None
 0.87A 6g1pA-4ox2A:
undetectable		 6g1pA-4ox2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 THR A 217
GLU A 159
ASN A 238
 None
 0.87A 6nj9K-4ox2A:
undetectable		 6nj9K-4ox2A:
20.79