SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ALA A  44
VAL A  42
TRP A  73
 None
 0.86A 1av2C-4oxcA:
undetectable
1av2D-4oxcA:
undetectable		 1av2C-4oxcA:
6.31
1av2D-4oxcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ALA A  44
VAL A  42
TRP A  73
 None
 0.80A 1w5uC-4oxcA:
undetectable
1w5uD-4oxcA:
undetectable		 1w5uC-4oxcA:
6.31
1w5uD-4oxcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 TRP A  73
ALA A  44
VAL A  42
 None
 0.76A 2izqA-4oxcA:
undetectable
2izqB-4oxcA:
undetectable		 2izqA-4oxcA:
6.31
2izqB-4oxcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A  37
GLY A  58
TYR A  54
 None
 0.68A 2vouA-4oxcA:
undetectable		 2vouA-4oxcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A  37
GLY A  58
TYR A  54
 None
 0.67A 2vouB-4oxcA:
undetectable		 2vouB-4oxcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A  37
GLY A  58
TYR A  54
 None
 0.67A 2vouC-4oxcA:
undetectable		 2vouC-4oxcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 PHE A  33
SER A  40
VAL A  42
TRP A  73
 None
 1.24A 3dqtA-4oxcA:
undetectable
3dqtB-4oxcA:
undetectable		 3dqtA-4oxcA:
12.74
3dqtB-4oxcA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ARG A  72
ASP A  77
ASP A  71
 None
 0.77A 3jayA-4oxcA:
undetectable		 3jayA-4oxcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ARG A  72
ASP A  77
ASP A  71
 None
 0.81A 3jb2A-4oxcA:
undetectable		 3jb2A-4oxcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ARG A  72
ASP A  77
ASP A  71
 None
 0.87A 3jb3A-4oxcA:
undetectable		 3jb3A-4oxcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ALA A  44
VAL A  42
TRP A  73
 None
 0.75A 3l8lA-4oxcA:
undetectable
3l8lB-4oxcA:
undetectable		 3l8lA-4oxcA:
6.31
3l8lB-4oxcA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 ALA A  44
VAL A  42
TRP A  73
 None
 0.73A 3l8lC-4oxcA:
undetectable
3l8lD-4oxcA:
undetectable		 3l8lC-4oxcA:
6.31
3l8lD-4oxcA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 PHE A  33
SER A  40
VAL A  42
TRP A  73
 None
 1.24A 4k5jA-4oxcA:
undetectable
4k5jB-4oxcA:
undetectable		 4k5jA-4oxcA:
11.96
4k5jB-4oxcA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 VAL A  42
SER A  43
THR A  46
 None
 0.36A 4luhA-4oxcA:
undetectable		 4luhA-4oxcA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 PHE A  33
SER A  40
VAL A  42
TRP A  73
 None
 1.25A 5vv7A-4oxcA:
undetectable
5vv7B-4oxcA:
undetectable		 5vv7A-4oxcA:
11.96
5vv7B-4oxcA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 PHE A  33
SER A  40
VAL A  42
TRP A  73
 None
 1.29A 5vvnA-4oxcA:
undetectable
5vvnB-4oxcA:
undetectable		 5vvnA-4oxcA:
11.96
5vvnB-4oxcA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 SER A  40
VAL A  42
TRP A  73
PHE A  33
 None
 1.27A 6av6A-4oxcA:
undetectable
6av6B-4oxcA:
undetectable		 6av6A-4oxcA:
22.52
6av6B-4oxcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 PHE A  33
SER A  40
VAL A  42
TRP A  73
 None
 1.30A 6av6C-4oxcA:
undetectable
6av6D-4oxcA:
undetectable		 6av6C-4oxcA:
22.52
6av6D-4oxcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 SER A  40
VAL A  42
TRP A  73
PHE A  33
 None
 1.30A 6av7A-4oxcA:
undetectable
6av7B-4oxcA:
undetectable		 6av7A-4oxcA:
22.52
6av7B-4oxcA:
22.52